ES2159628T3 - Gen de una proteina de union a fk506. - Google Patents

Gen de una proteina de union a fk506.

Info

Publication number
ES2159628T3
ES2159628T3 ES95910782T ES95910782T ES2159628T3 ES 2159628 T3 ES2159628 T3 ES 2159628T3 ES 95910782 T ES95910782 T ES 95910782T ES 95910782 T ES95910782 T ES 95910782T ES 2159628 T3 ES2159628 T3 ES 2159628T3
Authority
ES
Spain
Prior art keywords
gene
binding protein
protein
recombinant
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95910782T
Other languages
English (en)
Inventor
Sadahito Shin
Tsutomu Fujiwara
Shiro Okuno
Hisanobu Hirano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2159628T3 publication Critical patent/ES2159628T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN GEN DE LA PROTEINA DE UNION FK506 QUE CONTIENE UNA SECUENCIA DE BASE CODIFICANTE PARA LA SECUENCIA DE AMINIACIDO MOSTRADA BAJO SEQ ID NO:1, EN PARTICULAR COMO FK506 UNIENDO A UN GEN PROTEICO CONTENIENDO LA SECUENCIA DE AMINOACIDO MOSTRADA BAJO SEQ ID NO:2, UN METODO PARA PRODUCIR UNA PROTEINA DE UNION FK506 RECOMBINANTE A TRAVES DE LA EXPRESION DE DICHO GEN, Y LA PROTEINA RECOMBINATE ASI PRODUCIDA. EL USO DEL GEN DE LA PRESENTE INVENCION PERMITE LA EXPRESION DE LA PROTEINA DE UNION FK506, Y LA PROTEINA ES UTIL PARTICULARMENTE EN ELUCIDAR EL MECANISMO DE INMUNOSUPRESION EN CUERPOS VIVOS O EN EL DESARROLLO Y EL CONTROL DE AGENTES TERAPEUTICOS PARA TRASTORNOS AUTOINMUNES ( POR EJEMPLO, SLE., REUMATISMO, ETC) ENTRE OTROS.
ES95910782T 1994-03-10 1995-03-09 Gen de una proteina de union a fk506. Expired - Lifetime ES2159628T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6067967A JPH07250686A (ja) 1994-03-10 1994-03-10 Ｆｋ５０６結合蛋白遺伝子

Publications (1)

Publication Number Publication Date
ES2159628T3 true ES2159628T3 (es) 2001-10-16

Family

ID=13360261

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95910782T Expired - Lifetime ES2159628T3 (es) 1994-03-10 1995-03-09 Gen de una proteina de union a fk506.

Country Status (10)

Country Link
US (1) US6136584A (es)
EP (1) EP0754754B1 (es)
JP (1) JPH07250686A (es)
AT (1) ATE204903T1 (es)
CA (1) CA2185098C (es)
DE (1) DE69522444T2 (es)
DK (1) DK0754754T3 (es)
ES (1) ES2159628T3 (es)
PT (1) PT754754E (es)
WO (1) WO1995024480A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457182A (en) * 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
DE19907598A1 (de) * 1999-02-22 2000-08-24 Schulz Burkhard DNA Sequenz kodierend ein FKBP ähnliches Protein, Plasmide, Bakterien, Hefen und Pflanzen enthaltend dieses Protein sowie Mutanten in Arabidopsis für dieses Gen, die in der Ausprägung der Pflanzenarchitektur, der Reaktion gegenüber Brassinosteroiden und ihren Verbindungen und durch Ethylen vermittelten Gravitropismus der Wurzel defekt sind

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2982908B2 (ja) * 1990-07-11 1999-11-29 東燃株式会社 ヒトｆｋ５０６結合蛋白質をコードするｄｎａ
CA2052928A1 (en) * 1990-10-15 1992-04-16 John J. Siekierka Genes encoding the human fk-506 binding protein and a.s. cerevisiae homolog, fkb1 and their expression
US5457182A (en) * 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6

Also Published As

Publication number Publication date
DE69522444D1 (de) 2001-10-04
EP0754754A1 (en) 1997-01-22
PT754754E (pt) 2002-01-30
CA2185098A1 (en) 1995-09-14
ATE204903T1 (de) 2001-09-15
EP0754754B1 (en) 2001-08-29
US6136584A (en) 2000-10-24
EP0754754A4 (en) 1999-11-17
DK0754754T3 (da) 2001-10-08
WO1995024480A1 (fr) 1995-09-14
DE69522444T2 (de) 2002-05-16
JPH07250686A (ja) 1995-10-03
CA2185098C (en) 2002-06-18

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