ES2155842T3 - Procedimiento para la determinacion de la agregacion de trombocitos. - Google Patents
Procedimiento para la determinacion de la agregacion de trombocitos.Info
- Publication number
- ES2155842T3 ES2155842T3 ES94119803T ES94119803T ES2155842T3 ES 2155842 T3 ES2155842 T3 ES 2155842T3 ES 94119803 T ES94119803 T ES 94119803T ES 94119803 T ES94119803 T ES 94119803T ES 2155842 T3 ES2155842 T3 ES 2155842T3
- Authority
- ES
- Spain
- Prior art keywords
- determination
- thrombocytes
- aggregation
- procedure
- fibrine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002776 aggregation Effects 0.000 title abstract 2
- 238000004220 aggregation Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCESO PARA LA DETERMINACION DE TROMBOCITOS EN PRESENCIA DE UN INHIBIDOR DE AGREGACION DE FIBRINA, QUE PREVIENE LA FORMACION DE UN ELEMENTO DE FIBRINA PERTURBADOR ASI COMO UN DIAGNOSTICO PARA LA DETERMINACION DEL EFECTO INHIBIDOR DE AGREGACION DE TROMBOCITOS CORRESPONDIENTE A LOS INHIBIDORES DE TROMBINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4344919A DE4344919A1 (de) | 1993-12-30 | 1993-12-30 | Verfahren zur Bestimmung der Thrombozytenaggregation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155842T3 true ES2155842T3 (es) | 2001-06-01 |
Family
ID=6506496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94119803T Expired - Lifetime ES2155842T3 (es) | 1993-12-30 | 1994-12-15 | Procedimiento para la determinacion de la agregacion de trombocitos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5563041A (es) |
EP (1) | EP0661383B1 (es) |
JP (1) | JP3684451B2 (es) |
KR (1) | KR950018482A (es) |
AT (1) | ATE199939T1 (es) |
AU (1) | AU702099B2 (es) |
CA (1) | CA2138931C (es) |
DE (2) | DE4344919A1 (es) |
ES (1) | ES2155842T3 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19781870T1 (de) * | 1996-04-30 | 2000-02-24 | Medtronic Inc | Verfahren zur Bestimmung der Blutplättcheninhibitor-Ansprechempfindlichkeit |
US6221672B1 (en) | 1996-04-30 | 2001-04-24 | Medtronic, Inc. | Method for determining platelet inhibitor response |
US6043871A (en) * | 1997-03-03 | 2000-03-28 | Brigham Young University | System and method for measuring blood platelet function |
US5951951A (en) * | 1997-04-30 | 1999-09-14 | Medtronic, Inc. | Platelet function evaluation technique for citrated whole blood |
US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
JP4176157B2 (ja) * | 1997-07-23 | 2008-11-05 | 株式会社トクヤマ | 凝固パラメーターの決定方法 |
US6410337B1 (en) * | 1997-09-18 | 2002-06-25 | Helena Laboratories Corporation | Method of platlet function analysis using platelet count |
US20040219681A1 (en) * | 1997-09-18 | 2004-11-04 | Ridgway Helen Jane | Two-tube method and system for platelet function analysis using platelet count |
US20040219682A1 (en) * | 1997-09-18 | 2004-11-04 | Ridgway Helen Jane | Single-tube method and system for platelet function analysis |
DE19756773A1 (de) | 1997-12-19 | 1999-06-24 | Dade Behring Marburg Gmbh | Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik |
US6165795A (en) * | 1998-06-25 | 2000-12-26 | Cardiovascular Diagnostics, Inc. | Methods for performing fibrinogen assays using dry chemical reagents containing ecarin and magnetic particles |
DE10041238A1 (de) * | 2000-08-22 | 2002-03-07 | Aventis Res & Tech Gmbh & Co | Verfahren zur Identifizierung spezifisch spaltbarer peptide und Verwendung solcher Peptidsequenzen |
US6448024B1 (en) | 2000-10-03 | 2002-09-10 | Roche Diagnostics Corporation | Method, reagent, cartridge, and device for determining fibrinogen |
US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
ES2378544T3 (es) | 2003-07-08 | 2012-04-13 | Accumetrics, Inc. | Activación selectiva de plaquetas para el seguimiento de terapia con antagonistas de ADP |
AU2005248772B2 (en) | 2004-05-17 | 2010-11-25 | Medtronic, Inc. | Point of care heparin determination system |
CA2588560A1 (en) * | 2004-12-29 | 2006-07-06 | Labo Cosprophar Ag | Cosmetic composition for skin application suitable for relaxing expression wrinkles |
US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
DK1955078T3 (da) | 2005-11-17 | 2013-09-23 | Biogen Idec Inc | Blodpladeaggregeringsassays |
US8289514B2 (en) | 2008-03-05 | 2012-10-16 | Aggredyne, Inc. | Systems for measuring properties of a physiological fluid suspension |
EP2937695B1 (en) * | 2012-12-18 | 2018-10-24 | Daiichi Sankyo Company, Limited | Method for measuring thrombin generation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3811647A1 (de) * | 1988-04-07 | 1989-10-26 | Behringwerke Ag | Verfahren und verpackung enthaltend mittel zur kinetischen bestimmung von faktor xiii |
US5246832A (en) * | 1990-06-20 | 1993-09-21 | University Of Massachusetts Medical Center | Platelet analysis in whole blood |
DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
DE4133946A1 (de) * | 1991-10-14 | 1993-04-15 | Behringwerke Ag | Funktioneller test und reagenz zur bestimmung von fibrinogen |
-
1993
- 1993-12-30 DE DE4344919A patent/DE4344919A1/de not_active Withdrawn
-
1994
- 1994-12-15 DE DE59409698T patent/DE59409698D1/de not_active Expired - Lifetime
- 1994-12-15 EP EP94119803A patent/EP0661383B1/de not_active Expired - Lifetime
- 1994-12-15 ES ES94119803T patent/ES2155842T3/es not_active Expired - Lifetime
- 1994-12-15 AT AT94119803T patent/ATE199939T1/de active
- 1994-12-22 CA CA002138931A patent/CA2138931C/en not_active Expired - Fee Related
- 1994-12-28 KR KR1019940037713A patent/KR950018482A/ko not_active Application Discontinuation
- 1994-12-28 JP JP32651494A patent/JP3684451B2/ja not_active Expired - Fee Related
- 1994-12-29 US US08/365,759 patent/US5563041A/en not_active Expired - Lifetime
- 1994-12-29 AU AU81788/94A patent/AU702099B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0661383A2 (de) | 1995-07-05 |
EP0661383A3 (de) | 1997-12-17 |
EP0661383B1 (de) | 2001-03-21 |
AU702099B2 (en) | 1999-02-11 |
DE4344919A1 (de) | 1995-07-06 |
AU8178894A (en) | 1995-07-06 |
US5563041A (en) | 1996-10-08 |
CA2138931A1 (en) | 1995-07-01 |
KR950018482A (ko) | 1995-07-22 |
ATE199939T1 (de) | 2001-04-15 |
DE59409698D1 (de) | 2001-04-26 |
JP3684451B2 (ja) | 2005-08-17 |
JPH07203994A (ja) | 1995-08-08 |
CA2138931C (en) | 2008-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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