ES2154551B1 - Nuevos derivados de tetrazol como agentes antidiabeticos. - Google Patents
Nuevos derivados de tetrazol como agentes antidiabeticos.Info
- Publication number
- ES2154551B1 ES2154551B1 ES9801650A ES9801650A ES2154551B1 ES 2154551 B1 ES2154551 B1 ES 2154551B1 ES 9801650 A ES9801650 A ES 9801650A ES 9801650 A ES9801650 A ES 9801650A ES 2154551 B1 ES2154551 B1 ES 2154551B1
- Authority
- ES
- Spain
- Prior art keywords
- sub
- antidiabetic agents
- tetrazol
- new derivatives
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevos derivados de tetrazol como agentes antidiabeticos. La presente invención se refiere a compuestos de fórmula (I), **FORMULA01** en la que: m = 1-5; n = 1-3; X es -O-, ó - NR{sub,1}; R{sub,1} es H, alquilo C{sub,1}-C{sub,6}, arilo o aralquilo; Ar es A, B, C o D, donde: Y es O ó S; R{sub,2} es - NH{sub,2}, -NO{sub,2}; R{sub,3} y R{sub,4} son independientemente H, alquilo C{sub,1}-C{sub,6}, alquenilo C{sub,2}-C{sub,6}, OH, OR{sub,5}, NH{sub,2}, NR{sub,5}, N0{sub,2}, halógeno (F, Cl, Br, I), ó CO-R{sub,5}, o bien forman conjuntamente un anillo aromático fusionado substituido o no substituido, siendo R{sub,5} un H, alquilo C{sub,1}-C{sub,6}, arilo, o aralquilo; a sus posibles sales farmacéuticamente aceptables, formas tautómeras, a un procedimiento para su obtención y a su uso para la fabricación de un medicamento. Los compuestos de la presente invención presentan una elevada actividad hipoglucemiante.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9801650A ES2154551B1 (es) | 1998-08-03 | 1998-08-03 | Nuevos derivados de tetrazol como agentes antidiabeticos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9801650A ES2154551B1 (es) | 1998-08-03 | 1998-08-03 | Nuevos derivados de tetrazol como agentes antidiabeticos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2154551A1 ES2154551A1 (es) | 2001-04-01 |
| ES2154551B1 true ES2154551B1 (es) | 2001-10-16 |
Family
ID=8304752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9801650A Expired - Fee Related ES2154551B1 (es) | 1998-08-03 | 1998-08-03 | Nuevos derivados de tetrazol como agentes antidiabeticos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2154551B1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6958355B2 (en) | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6768008B2 (en) * | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| AU2001294673A1 (en) | 2000-09-21 | 2002-04-02 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845231A (en) * | 1988-02-12 | 1989-07-04 | American Home Products Corporation | Tetrazoles and their use as hypoglycemic agents |
| HUT65619A (en) * | 1990-07-03 | 1994-07-28 | Yamanouchi Pharma Co Ltd | Process for producing bisheterocyclic compounds and pharmaceutical preparations containing them |
| US5591862A (en) * | 1993-06-11 | 1997-01-07 | Takeda Chemical Industries, Ltd. | Tetrazole derivatives, their production and use |
| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
-
1998
- 1998-08-03 ES ES9801650A patent/ES2154551B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2154551A1 (es) | 2001-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20010401 Kind code of ref document: A1 Effective date: 20010401 |
|
| FD1A | Patent lapsed |
Effective date: 20050804 |