ES2152306T3 - Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t. - Google Patents

Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t.

Info

Publication number
ES2152306T3
ES2152306T3 ES94908854T ES94908854T ES2152306T3 ES 2152306 T3 ES2152306 T3 ES 2152306T3 ES 94908854 T ES94908854 T ES 94908854T ES 94908854 T ES94908854 T ES 94908854T ES 2152306 T3 ES2152306 T3 ES 2152306T3
Authority
ES
Spain
Prior art keywords
cell
antigen
receiver
defined regions
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908854T
Other languages
English (en)
Inventor
Charles William Rittershaus
Patrick Kung
Nancy Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2152306T3 publication Critical patent/ES2152306T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

EL INVENTO SE REFIERE A REACTIVOS DE ANTICUERPOS MONOCLONALES CON UN MIEMBRO DE LA REGION VARIABLE DE LA FAMILIA VBETA3 DE LA CADENA BETA DE TCR. MAS PARTICULARMENTE, EL INVENTO HACE PROVISION PARA LA DETECCION DE LA SUBFAMILIA VBETA3.1. EN UNA PRESENTACION ESPECIFICA EL INVENTO PROPORCIONA IDENTIFICACION DE VBETA3.1, SIN REACCION TRANSVERSAL CON OTRAS REGIONES VARIABLES DE LA FAMILIA VBETA3. EN UNA PRESENTACION ESPECIFICA, LOS ANTICUERPOS MONOCLONALES DEL INVENTO NO REACCIONAN CON VBETA3.2. EN PARTICULAR, EL INVENTO PROPORCIONA ANTICUERPOS MONOCLONALES, DENOMINADOS 5E4 Y 8F10, QUE REACCIONAN CON LA REGION VARIABLE DE UN ELEMENTO DE LA FAMILIA VBETA3. EN VARIAS PRESENTACIONES DEL INVENTO, ESTOS ANTICUERPOS, O SUS FRAGMENTOS O DERIVADOS, SE PUEDEN UTILIZAR PARA LIGAR CON UN ELEMENTO DE SECUENCIAS AMINOACIDAS DE REGION VARIABLE TCR DE LA FAMILIA VBETA3, YA COMO PARTE DE UN TCR INTACTO O PEPTIDO, O MOLECULA DE SUPERFICIE DE CELULA T, O UN FRAGMENTO SUYO. LOS ANTICUERPOS MONOCLONALES SON UTILESPARA EL DIAGNOSTICO O TERAPIA DE LA ENFERMEDAD AUTOINMUNE, EN PARTICULAR ARTRITIS REUMATOIDE.
ES94908854T 1992-08-31 1993-08-27 Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t. Expired - Lifetime ES2152306T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/938,906 US5766947A (en) 1988-12-14 1992-08-31 Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor

Publications (1)

Publication Number Publication Date
ES2152306T3 true ES2152306T3 (es) 2001-02-01

Family

ID=25472181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908854T Expired - Lifetime ES2152306T3 (es) 1992-08-31 1993-08-27 Anticuerpos monoclonales reactivos con regiones definidas del receptor del antigeno de la celula t.

Country Status (12)

Country Link
US (1) US5766947A (es)
EP (2) EP0867451A3 (es)
JP (1) JPH08502246A (es)
AT (1) ATE197316T1 (es)
AU (1) AU705925B2 (es)
CA (1) CA2143186A1 (es)
DE (1) DE69329621T2 (es)
DK (1) DK0662148T3 (es)
ES (1) ES2152306T3 (es)
GR (1) GR3035090T3 (es)
PT (1) PT662148E (es)
WO (1) WO1994005801A1 (es)

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US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
GB9610992D0 (en) * 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
IL122233A (en) * 1996-12-06 2001-04-30 Akzo Nobel Nv Method of generating monoclonal antibodies to cell wall and pharmaceutical preparations and diagnostic agents containing them
GB9906233D0 (en) * 1999-03-19 1999-05-12 Univ Newcastle Bone formation
US7074403B1 (en) * 1999-06-09 2006-07-11 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target B-cells
US7541184B2 (en) * 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
US20040175373A1 (en) * 2002-06-28 2004-09-09 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040151704A1 (en) * 2002-06-28 2004-08-05 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20050084967A1 (en) * 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7951374B2 (en) * 2004-12-14 2011-05-31 University Of South Florida Methods for inhibiting STAT3 signaling in immune cells
JP2012501178A (ja) * 2008-08-26 2012-01-19 マクロジェニクス，インコーポレーテッド Ｔ細胞受容体抗体およびその使用方法
EP2408812B1 (en) 2009-03-17 2015-12-16 CardioVax, LLC Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis and related proteins, peptides and compositions
CA2780753A1 (en) 2009-11-14 2011-05-19 Kuang-Yuh Chyu Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
CN103501806A (zh) 2010-11-12 2014-01-08 赛达斯西奈医疗中心 用于治疗和/或预防动脉瘤的免疫调节方法和系统
CA2817543A1 (en) 2010-11-12 2012-06-07 Cedars-Sinai Medical Center Immunomodulatory methods and systems for treatment and/or prevention of hypertension
MX2017015619A (es) * 2015-06-01 2018-08-15 Medigene Immunotherapies Gmbh Anticuerpos especificos de receptor de celulas t.
EA201792661A1 (ru) 2015-06-01 2018-05-31 Медиджин Иммьюнотерапиз Гмбх Способ получения антител против т-клеточного рецептора
WO2016193299A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh T cell receptor library
DE102015009489A1 (de) * 2015-07-22 2017-01-26 Audi Ag Verfahren zum Betreiben einer Antriebseinrichtung sowie entsprechende Antriebseinrichtung
US11459540B2 (en) * 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) * 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
JP6697562B2 (ja) 2015-12-23 2020-05-20 メディジーン イミュノテラピーズ ゲーエムベーハー 樹状細胞組成物
RU2694412C9 (ru) 2017-12-25 2019-09-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Моноклональные антитела и способы их применения
CA3098420A1 (en) * 2018-06-01 2019-12-05 Novartis Ag Binding molecules against bcma and uses thereof
US11845797B2 (en) 2018-07-03 2023-12-19 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
RU2711871C1 (ru) 2018-12-25 2020-01-23 Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Моноклональные антитела, которые специфически связываются с участком бета цепи семейства TRBV-9 Т-клеточного рецептора человека, и способы их применения
RU2712251C1 (ru) 2018-12-25 2020-01-27 Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Гуманизированные антитела против участка бета цепи 9-го семейства TRBV9 TKP человека, и способы их применения
SG11202109122SA (en) * 2019-02-21 2021-09-29 Marengo Therapeutics Inc Anti-tcr antibody molecules and uses thereof
WO2021097325A1 (en) * 2019-11-14 2021-05-20 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
CA3166629A1 (en) * 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof

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Also Published As

Publication number Publication date
US5766947A (en) 1998-06-16
EP0662148A1 (en) 1995-07-12
AU4971393A (en) 1994-03-29
EP0867451A2 (en) 1998-09-30
WO1994005801A1 (en) 1994-03-17
ATE197316T1 (de) 2000-11-15
DE69329621D1 (de) 2000-12-07
DK0662148T3 (da) 2000-12-18
JPH08502246A (ja) 1996-03-12
AU705925B2 (en) 1999-06-03
CA2143186A1 (en) 1994-03-17
PT662148E (pt) 2001-04-30
DE69329621T2 (de) 2001-03-08
GR3035090T3 (en) 2001-03-30
EP0662148B1 (en) 2000-11-02
EP0867451A3 (en) 2000-03-29

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