ES2151223T3 - Agentes antifungicos triazolicos. - Google Patents

Agentes antifungicos triazolicos.

Info

Publication number
ES2151223T3
ES2151223T3 ES97200348T ES97200348T ES2151223T3 ES 2151223 T3 ES2151223 T3 ES 2151223T3 ES 97200348 T ES97200348 T ES 97200348T ES 97200348 T ES97200348 T ES 97200348T ES 2151223 T3 ES2151223 T3 ES 2151223T3
Authority
ES
Spain
Prior art keywords
alkyl
triazolic
het
halo
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97200348T
Other languages
English (en)
Inventor
Andrew Simon Bell
Peter Thomas Stephenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Research and Development Co NV SA
Original Assignee
Pfizer Research and Development Co NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research and Development Co NV SA filed Critical Pfizer Research and Development Co NV SA
Application granted granted Critical
Publication of ES2151223T3 publication Critical patent/ES2151223T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

COMPUESTOS ANTIFUNGICOS DE FORMULA (I): Y SALES O SOLVATOS DE DICHOS COMPUESTOS APTOS PARA USOS FARMACEUTICOS, DONDE X ES CH O N; R{SUP,1} ES UN GRUPO FENILO SUSTITUIDO CON 1 O 3 SUSTITUYENTES, CADA UNO DE ELLOS INDEPENDIENTEMENTE SELECCIONADO DE HALO Y CF{SUB,3}; R{SUP,2} ES (HIDROXI) ALQUILO C{SUB,1} - C{SUB,4}, CONH{SUB,2}, S(O){SUB,M} (ALQUILO C{SUB,1} - C{SUB,4}), AR O HET; M ES 1 O 2; AR ES UN GRUPO FENILO OPCIONALMENTE MONOSUSTITUIDO POR HALO O CF{SUB,3}, Y HET ES UN GRUPO HETEROCICLICO AROMATICO NITROGENADO DE 6 MIEMBROS UNIDO A C QUE CONTIENE 1 O 2 ATOMOS DE NITROGENO, O UN GRUPO HETEROCICLICO AROMATICO NITROGENADO DE 5 MIEMBROS UNIDO A C O N QUE CONTIENE ENTRE 2 Y 4 ATOMOS DE NITROGENO, DONDE CUALQUIERA DE ESOS GRUPOS HETEROCICLICOS PUEDE SER SUSTITUIDO POR ALQUILO C{SUB,1} - C{SUB,4} O (ALCOXI C{SUB,1} - C{SUB,4}) METIL.
ES97200348T 1996-03-19 1997-02-06 Agentes antifungicos triazolicos. Expired - Lifetime ES2151223T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9605705.4A GB9605705D0 (en) 1996-03-19 1996-03-19 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2151223T3 true ES2151223T3 (es) 2000-12-16

Family

ID=10790616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97200348T Expired - Lifetime ES2151223T3 (es) 1996-03-19 1997-02-06 Agentes antifungicos triazolicos.

Country Status (11)

Country Link
US (3) US5981560A (es)
EP (1) EP0796858B1 (es)
JP (1) JP2987339B2 (es)
AT (1) ATE197304T1 (es)
CA (1) CA2200169C (es)
DE (1) DE69703403T2 (es)
DK (1) DK0796858T3 (es)
ES (1) ES2151223T3 (es)
GB (1) GB9605705D0 (es)
GR (1) GR3035029T3 (es)
PT (1) PT796858E (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11051514B2 (en) 2015-05-18 2021-07-06 Mycovia Pharmaceuticals, Inc. Antifungal compounds

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005027482D1 (de) * 2004-11-30 2011-05-26 Sumitomo Chemical Co Verfahren zur herstellung eines epoxytriazolderivats
PT2563771E (pt) * 2010-04-24 2016-03-31 Viamet Pharmaceuticals Inc Compostos inibidores de metaloenzimas
US8809378B2 (en) 2011-06-19 2014-08-19 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20160137619A (ko) * 2014-03-26 2016-11-30 바스프 에스이 살진균제로서의 치환된 [1,2,4]트리아졸 및 이미다졸 화합물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2431407C2 (de) 1974-06-29 1982-12-02 Bayer Ag, 5090 Leverkusen 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
GB2078719B (en) 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
DE3262386D1 (en) 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
EP0440608A1 (en) * 1987-12-17 1991-08-14 E.I. Du Pont De Nemours And Company Antifungal carbinols
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
CA2145458A1 (en) * 1994-03-28 1995-09-29 Hiroki Kodama Triazole compound and production process and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11051514B2 (en) 2015-05-18 2021-07-06 Mycovia Pharmaceuticals, Inc. Antifungal compounds

Also Published As

Publication number Publication date
GB9605705D0 (en) 1996-05-22
US6376526B1 (en) 2002-04-23
JP2987339B2 (ja) 1999-12-06
CA2200169A1 (en) 1997-09-19
CA2200169C (en) 2001-04-03
DE69703403D1 (de) 2000-12-07
DK0796858T3 (da) 2000-12-27
PT796858E (pt) 2001-03-30
EP0796858A1 (en) 1997-09-24
ATE197304T1 (de) 2000-11-15
DE69703403T2 (de) 2001-03-08
GR3035029T3 (en) 2001-03-30
JPH107663A (ja) 1998-01-13
US5981560A (en) 1999-11-09
US6124325A (en) 2000-09-26
EP0796858B1 (en) 2000-11-02

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