ES2148310T3 - Procedimiento para fabricar conjugados de lipidos. - Google Patents

Procedimiento para fabricar conjugados de lipidos.

Info

Publication number
ES2148310T3
ES2148310T3 ES94901260T ES94901260T ES2148310T3 ES 2148310 T3 ES2148310 T3 ES 2148310T3 ES 94901260 T ES94901260 T ES 94901260T ES 94901260 T ES94901260 T ES 94901260T ES 2148310 T3 ES2148310 T3 ES 2148310T3
Authority
ES
Spain
Prior art keywords
procedure
lipid conjugates
conjugates
manufacture
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901260T
Other languages
English (en)
Inventor
Barbara Yu-Fong Wan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ES2148310T3 publication Critical patent/ES2148310T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/21—Hydrocarbon
    • Y10T436/214—Acyclic [e.g., methane, octane, isoparaffin, etc.]
    • Y10T436/216—Unsaturated [e.g., ethylene, diene, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCESO EFICIENTE, TECNICAMENTE DIRECTO Y BARATO PARA LA GENERACION DE CONJUGADOS DE LIPIDOS Y MOLECULAS BIOLOGICAMENTE ACTIVAS PARA LA PRODUCCION DE MEDIOS DE SUMINISTRO DE FARMACOS; O CONJUGADOS DE LIPIDOS CON POLIAMINAS PARA LA PRODUCCION DE LIPIDOS CATIONICOS.
ES94901260T 1992-11-05 1993-11-05 Procedimiento para fabricar conjugados de lipidos. Expired - Lifetime ES2148310T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/972,361 US5329029A (en) 1992-11-05 1992-11-05 Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates

Publications (1)

Publication Number Publication Date
ES2148310T3 true ES2148310T3 (es) 2000-10-16

Family

ID=25519564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901260T Expired - Lifetime ES2148310T3 (es) 1992-11-05 1993-11-05 Procedimiento para fabricar conjugados de lipidos.

Country Status (9)

Country Link
US (2) US5329029A (es)
EP (1) EP0666762B1 (es)
AT (1) ATE194776T1 (es)
DE (1) DE69329069T2 (es)
DK (1) DK0666762T3 (es)
ES (1) ES2148310T3 (es)
GR (1) GR3033870T3 (es)
PT (1) PT666762E (es)
WO (1) WO1994009827A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869534A (en) * 1992-05-21 1999-02-09 The Picower Institute For Medical Research Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
FR2714830B1 (fr) * 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
AUPM747694A0 (en) * 1994-08-16 1994-09-08 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids and peptides
WO1997020076A1 (en) * 1995-11-29 1997-06-05 Nexstar Pharmaceuticals, Inc. Methods for optimizing multicomponent formulations
AUPN741696A0 (en) * 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
EP0784984B1 (en) * 1996-01-17 2003-07-02 F. Hoffmann-La Roche Ag Transfection competent molecules
JP4512882B2 (ja) * 1996-02-09 2010-07-28 チェング ピー―ワン 受容体リガンドにより促進される生物活性分子の送達
US20020102253A1 (en) * 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
WO1999015206A1 (en) * 1997-09-23 1999-04-01 Megabios Corporation Methods for preparing lipids/polynucleotide transfection complexes
IL151024A0 (en) 2000-02-15 2003-02-12 Genzyme Corp Conjugates of a biopolymer and a therapeutic agent
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
US20030229013A1 (en) * 2001-12-07 2003-12-11 Shih-Kwang Wu Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
US7299805B2 (en) * 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US10858384B2 (en) 2004-03-22 2020-12-08 Kode Biotech Limited Synthetic molecule constructs
EP1735323B1 (en) 2004-03-22 2017-08-30 Kode Biotech Limited Synthetic membrane anchors
US7968124B2 (en) * 2004-07-13 2011-06-28 Lyotropic Therapeutics, Inc. Compositions for the reversal and detoxification of anesthetics and other compounds and methods of their use
US20090162277A1 (en) * 2005-11-03 2009-06-25 Clemson University Lysophospholipids Solubilized Single-Walled Carbon Nanotubes
US8426152B2 (en) 2007-01-03 2013-04-23 Lamdagen Corporation Enzymatic assay for LSPR
CA2685269C (en) * 2007-04-27 2014-07-08 Kode Biotech Limited Carbohydrate-lipid constructs and their use in preventing or treating viral infection
US8105809B2 (en) * 2008-07-03 2012-01-31 Accera, Inc. Enzymatic synthesis of acetoacetate esters and derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2645866B1 (fr) * 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
AU3467193A (en) * 1991-12-17 1993-07-19 Regents Of The University Of California, The Gene therapy for cystic fibrosis transmembrane conductance regulator activity (CFTR)

Also Published As

Publication number Publication date
ATE194776T1 (de) 2000-08-15
DE69329069D1 (de) 2000-08-24
DK0666762T3 (da) 2000-09-18
EP0666762B1 (en) 2000-07-19
GR3033870T3 (en) 2000-10-31
US5329029A (en) 1994-07-12
EP0666762A1 (en) 1995-08-16
DE69329069T2 (de) 2000-12-21
WO1994009827A1 (en) 1994-05-11
PT666762E (pt) 2000-12-29
US5451661A (en) 1995-09-19

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