GR3033870T3 - Process for making lipid conjugates. - Google Patents
Process for making lipid conjugates.Info
- Publication number
- GR3033870T3 GR3033870T3 GR20000401505T GR20000401505T GR3033870T3 GR 3033870 T3 GR3033870 T3 GR 3033870T3 GR 20000401505 T GR20000401505 T GR 20000401505T GR 20000401505 T GR20000401505 T GR 20000401505T GR 3033870 T3 GR3033870 T3 GR 3033870T3
- Authority
- GR
- Greece
- Prior art keywords
- lipid
- biologically active
- acetoacetylated
- mixed
- active agent
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- -1 cationic lipid Chemical class 0.000 abstract 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/21—Hydrocarbon
- Y10T436/214—Acyclic [e.g., methane, octane, isoparaffin, etc.]
- Y10T436/216—Unsaturated [e.g., ethylene, diene, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/972,361 US5329029A (en) | 1992-11-05 | 1992-11-05 | Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates |
PCT/US1993/010601 WO1994009827A1 (en) | 1992-11-05 | 1993-11-05 | Process for making lipid conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3033870T3 true GR3033870T3 (en) | 2000-10-31 |
Family
ID=25519564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20000401505T GR3033870T3 (en) | 1992-11-05 | 2000-07-20 | Process for making lipid conjugates. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5329029A (el) |
EP (1) | EP0666762B1 (el) |
AT (1) | ATE194776T1 (el) |
DE (1) | DE69329069T2 (el) |
DK (1) | DK0666762T3 (el) |
ES (1) | ES2148310T3 (el) |
GR (1) | GR3033870T3 (el) |
PT (1) | PT666762E (el) |
WO (1) | WO1994009827A1 (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
FR2714830B1 (fr) * | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
AUPM747694A0 (en) * | 1994-08-16 | 1994-09-08 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids and peptides |
AU1085297A (en) * | 1995-11-29 | 1997-06-19 | Nexstar Pharmaceuticals, Inc. | Methods for optimizing multicomponent formulations |
AUPN741696A0 (en) * | 1996-01-05 | 1996-01-25 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids ii |
EP0784984B1 (en) * | 1996-01-17 | 2003-07-02 | F. Hoffmann-La Roche Ag | Transfection competent molecules |
ATE333892T1 (de) * | 1996-02-09 | 2006-08-15 | Pi-Wan Cheng | Kationisches lipid und rezeptorligand erleichterte gabe von biologisch aktiven molekuelen |
US20020102253A1 (en) * | 1997-02-25 | 2002-08-01 | Mynott Tracey Lehanne | Component of bromelain |
WO1999015206A1 (en) * | 1997-09-23 | 1999-04-01 | Megabios Corporation | Methods for preparing lipids/polynucleotide transfection complexes |
US6749865B2 (en) | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
JP2003522806A (ja) | 2000-02-15 | 2003-07-29 | ジェンザイム、コーポレーション | 改良された薬物送達のための生体高分子の修飾 |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
US20030229013A1 (en) * | 2001-12-07 | 2003-12-11 | Shih-Kwang Wu | Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same |
US7299805B2 (en) * | 2002-06-07 | 2007-11-27 | Marctec, Llc | Scaffold and method for implanting cells |
US10858384B2 (en) | 2004-03-22 | 2020-12-08 | Kode Biotech Limited | Synthetic molecule constructs |
ES2654578T3 (es) | 2004-03-22 | 2018-02-14 | Kode Biotech Limited | Anclajes de membrana sintética |
WO2008133534A2 (en) * | 2007-04-27 | 2008-11-06 | Kode Biotech Limited | Carbohydrate-lipid constructs and their use in preventing or treating viral infection |
US7968124B2 (en) * | 2004-07-13 | 2011-06-28 | Lyotropic Therapeutics, Inc. | Compositions for the reversal and detoxification of anesthetics and other compounds and methods of their use |
US20090162277A1 (en) * | 2005-11-03 | 2009-06-25 | Clemson University | Lysophospholipids Solubilized Single-Walled Carbon Nanotubes |
US8426152B2 (en) | 2007-01-03 | 2013-04-23 | Lamdagen Corporation | Enzymatic assay for LSPR |
US8105809B2 (en) * | 2008-07-03 | 2012-01-31 | Accera, Inc. | Enzymatic synthesis of acetoacetate esters and derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2645866B1 (fr) * | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
EP0625207A1 (en) * | 1991-12-17 | 1994-11-23 | The Regents Of The University Of California | Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr) |
-
1992
- 1992-11-05 US US07/972,361 patent/US5329029A/en not_active Expired - Fee Related
-
1993
- 1993-11-05 US US08/147,270 patent/US5451661A/en not_active Expired - Lifetime
- 1993-11-05 ES ES94901260T patent/ES2148310T3/es not_active Expired - Lifetime
- 1993-11-05 AT AT94901260T patent/ATE194776T1/de not_active IP Right Cessation
- 1993-11-05 PT PT94901260T patent/PT666762E/pt unknown
- 1993-11-05 WO PCT/US1993/010601 patent/WO1994009827A1/en active IP Right Grant
- 1993-11-05 DK DK94901260T patent/DK0666762T3/da active
- 1993-11-05 DE DE69329069T patent/DE69329069T2/de not_active Expired - Fee Related
- 1993-11-05 EP EP94901260A patent/EP0666762B1/en not_active Expired - Lifetime
-
2000
- 2000-07-20 GR GR20000401505T patent/GR3033870T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5329029A (en) | 1994-07-12 |
EP0666762A1 (en) | 1995-08-16 |
WO1994009827A1 (en) | 1994-05-11 |
EP0666762B1 (en) | 2000-07-19 |
ES2148310T3 (es) | 2000-10-16 |
PT666762E (pt) | 2000-12-29 |
US5451661A (en) | 1995-09-19 |
DK0666762T3 (da) | 2000-09-18 |
DE69329069T2 (de) | 2000-12-21 |
DE69329069D1 (de) | 2000-08-24 |
ATE194776T1 (de) | 2000-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ML | Lapse due to non-payment of fees |