ES2147184T3 - Composiciones de canales calcicos humanos y procedimientos. - Google Patents
Composiciones de canales calcicos humanos y procedimientos.Info
- Publication number
- ES2147184T3 ES2147184T3 ES92918611T ES92918611T ES2147184T3 ES 2147184 T3 ES2147184 T3 ES 2147184T3 ES 92918611 T ES92918611 T ES 92918611T ES 92918611 T ES92918611 T ES 92918611T ES 2147184 T3 ES2147184 T3 ES 2147184T3
- Authority
- ES
- Spain
- Prior art keywords
- human calcium
- calcium channels
- procedures
- compositions
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
Abstract
SE DESCRIBE UN ADN AISLADO QUE CODIFICA CADA UNO DE LOS CANALES DE CALCIO HUMANOS (ALFA)1-,(ALFA)2-, Y SUBUNIDADES UE INCLUYE SUBUNIDADES QUE SURGEN COMO VARIANTES DE EMPALME DE TRANSCRIPCIONES PRIMARIAS. LAS CELULAS Y VECTORES QUE CONTIENEN EL ADN Y LOS METODOS PARA IDENTIFICAR LOS COMPUESTOS QUE MODULAN LA ACTIVIDAD DE LOS CANALES DE CALCIO HUMANOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/745,206 US5429921A (en) | 1988-04-04 | 1991-08-15 | Assays for agonists and antagonists of recombinant human calcium channels |
US86835492A | 1992-04-10 | 1992-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2147184T3 true ES2147184T3 (es) | 2000-09-01 |
Family
ID=27114421
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92918611T Expired - Lifetime ES2147184T3 (es) | 1991-08-15 | 1992-08-14 | Composiciones de canales calcicos humanos y procedimientos. |
ES99119092T Expired - Lifetime ES2235417T3 (es) | 1991-08-15 | 1992-08-14 | Composiciones de canales de calcio humanos y procedimientos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99119092T Expired - Lifetime ES2235417T3 (es) | 1991-08-15 | 1992-08-14 | Composiciones de canales de calcio humanos y procedimientos. |
Country Status (10)
Country | Link |
---|---|
EP (3) | EP1469074B1 (es) |
JP (1) | JPH06509717A (es) |
AT (2) | ATE286976T1 (es) |
AU (1) | AU677571B2 (es) |
CA (1) | CA2113203C (es) |
DE (2) | DE69233469T2 (es) |
DK (1) | DK0598840T3 (es) |
ES (2) | ES2147184T3 (es) |
GR (1) | GR3033961T3 (es) |
WO (1) | WO1993004083A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6387696B1 (en) * | 1988-04-04 | 2002-05-14 | Merck & Co., Inc. | Human calcium channel compositions and methods |
US5876958A (en) * | 1988-04-04 | 1999-03-02 | Sibia Neurosciences, Inc. | Assays of cells expressing human calcium channels containing α1 β subunits |
US5874236A (en) * | 1988-04-04 | 1999-02-23 | Sibia Neurosciences. Inc. | DNA encoding human calcium channel α-1A, β1, β-2, and β-4 subunits, and assays using cells that express the subunits |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
US5912122A (en) | 1993-06-04 | 1999-06-15 | Sibia Neurosciences, Inc. | Nucleic acids encoding and method for detecting nucleic acid encoding human metabotropic glutamate receptor subtype mGluR6 |
US5623051A (en) * | 1994-11-10 | 1997-04-22 | University Of Washington | Methods and compositions for screening for presynaptic calcium channel blockers |
US5712158A (en) * | 1995-06-06 | 1998-01-27 | Warner-Lambert Company | Cell line for the rapid expression of functional calcium channels |
US6040436A (en) * | 1996-09-16 | 2000-03-21 | American Home Products Corporation | Nucleic acid encoding human neuronal calcium channel subunits |
DE69836229T2 (de) * | 1997-12-03 | 2007-08-23 | Merck & Co., Inc. | Zusammensetzungen von durch niedervolt aktivierten kalziumkanälen und verfahren |
WO1999029847A1 (en) * | 1997-12-05 | 1999-06-17 | Loyola University Of Chicago | T-type voltage-gated calcium channels and method of using same |
ES2378977T3 (es) | 1998-03-13 | 2012-04-19 | Brown University Research Foundation | Isoforma del canal de calcio del tipo N humano y usos de la misma |
CA2299611A1 (en) | 1998-06-02 | 1999-12-09 | Torben Bech-Hansen | Retinal calcium channel (alpha)1f-subunit gene |
AU780591B2 (en) * | 1999-05-05 | 2005-04-07 | Lexicon Genetics Incorporated | Novel human ion channel proteins |
CA2384911C (en) | 1999-09-16 | 2008-07-22 | Warner-Lambert Company | Method for the screening of .alpha.2. delta.-1 subunit binding ligands |
US6783952B1 (en) | 1999-09-16 | 2004-08-31 | Warner-Lambert Company | Secreted soluble α2δ-2, α2δ-3 or α2δ-4 calcium channel subunit polypeptides and screening assays using same |
US6962973B1 (en) | 1999-09-16 | 2005-11-08 | Warner-Lambert Company | Porcine α2δ-1 calcium channel subunit cDNA and soluble secreted α2δ-1 subunit polypeptides |
ATE405156T1 (de) * | 1999-10-26 | 2008-09-15 | Eisai R&D Man Co Ltd | N-KALZIUM-KANAL-ßKNOCKOUT-TIERß |
US7067714B1 (en) | 1999-10-26 | 2006-06-27 | Eisai Research Institute | N-calcium channel knockout animal |
US7294691B1 (en) | 2000-09-18 | 2007-11-13 | Warner Lambert Company | Soluble secreted α2δ-2calcium channel subunit polypeptide |
US20050208044A1 (en) | 2002-03-19 | 2005-09-22 | Jane Barclay | Methods for the identification of compounds useful for the suppression of chronic neuropathic pain and compositions thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950739A (en) * | 1988-02-10 | 1990-08-21 | New York University | Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels |
DE68926713T2 (de) * | 1988-04-04 | 1996-11-14 | Salk Inst Biotech Ind | Calciumkanal-zusammensetzungen und verfahren |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
DE4110785A1 (de) * | 1991-04-04 | 1992-10-08 | Bayer Ag | Gewebe-spezifische humane neuronale calcium-kanal-subtypen und deren verwendung |
-
1992
- 1992-08-14 ES ES92918611T patent/ES2147184T3/es not_active Expired - Lifetime
- 1992-08-14 EP EP04076651A patent/EP1469074B1/en not_active Expired - Lifetime
- 1992-08-14 DE DE69233469T patent/DE69233469T2/de not_active Expired - Lifetime
- 1992-08-14 EP EP99119092A patent/EP0992585B1/en not_active Expired - Lifetime
- 1992-08-14 JP JP5504507A patent/JPH06509717A/ja active Pending
- 1992-08-14 DE DE69230938T patent/DE69230938T2/de not_active Expired - Lifetime
- 1992-08-14 WO PCT/US1992/006903 patent/WO1993004083A1/en active IP Right Grant
- 1992-08-14 ES ES99119092T patent/ES2235417T3/es not_active Expired - Lifetime
- 1992-08-14 AU AU24957/92A patent/AU677571B2/en not_active Ceased
- 1992-08-14 AT AT99119092T patent/ATE286976T1/de not_active IP Right Cessation
- 1992-08-14 CA CA002113203A patent/CA2113203C/en not_active Expired - Fee Related
- 1992-08-14 EP EP92918611A patent/EP0598840B1/en not_active Expired - Lifetime
- 1992-08-14 AT AT92918611T patent/ATE191920T1/de not_active IP Right Cessation
- 1992-08-14 DK DK92918611T patent/DK0598840T3/da active
-
2000
- 2000-07-17 GR GR20000401646T patent/GR3033961T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1469074B1 (en) | 2008-11-26 |
DE69230938T2 (de) | 2000-10-12 |
CA2113203A1 (en) | 1993-03-04 |
WO1993004083A1 (en) | 1993-03-04 |
GR3033961T3 (en) | 2000-11-30 |
EP0598840B1 (en) | 2000-04-19 |
DE69230938D1 (de) | 2000-05-25 |
EP1469074A1 (en) | 2004-10-20 |
ATE191920T1 (de) | 2000-05-15 |
DK0598840T3 (da) | 2000-10-02 |
ATE286976T1 (de) | 2005-01-15 |
AU677571B2 (en) | 1997-05-01 |
EP0598840A1 (en) | 1994-06-01 |
CA2113203C (en) | 2001-01-02 |
EP0992585A2 (en) | 2000-04-12 |
JPH06509717A (ja) | 1994-11-02 |
ES2235417T3 (es) | 2005-07-01 |
EP0992585A3 (en) | 2000-11-15 |
AU2495792A (en) | 1993-03-16 |
DE69233469T2 (de) | 2005-12-22 |
EP0992585B1 (en) | 2005-01-12 |
DE69233469D1 (de) | 2005-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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