ES2143859T3 - Polimeros no trombogenos y anti-trombogenos. - Google Patents

Polimeros no trombogenos y anti-trombogenos.

Info

Publication number
ES2143859T3
ES2143859T3 ES97918264T ES97918264T ES2143859T3 ES 2143859 T3 ES2143859 T3 ES 2143859T3 ES 97918264 T ES97918264 T ES 97918264T ES 97918264 T ES97918264 T ES 97918264T ES 2143859 T3 ES2143859 T3 ES 2143859T3
Authority
ES
Spain
Prior art keywords
monomers
groups
pct
thrombogenic
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97918264T
Other languages
English (en)
Inventor
Ajay Kumar Luthra
Shivpal Singh Sandhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2143859T3 publication Critical patent/ES2143859T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/38—Esters containing sulfur
    • C08F220/385—Esters containing sulfur and containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
    • C08F220/285—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
    • C08F220/286—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety and containing polyethylene oxide in the alcohol moiety, e.g. methoxy polyethylene glycol (meth)acrylate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)

Abstract

PUEDEN PREPARARSE POLIMEROS CON PROPIEDADES NO TROMBOGENICAS, COPOLIMERIZANDO MONOMEROS DE AL MENOS TRES CLASES SELECCIONADOS DE (A) MONOMEROS CON GRUPOS DE SULFATOS, (B) MONOMEROS CON GRUPOS DE SULFONATOS, (C) MONOMEROS CON GRUPOS DE SULFAMATOS, Y (D) MONOMEROS CON GRUPOS DE ETER DE POLIXIALQUILENO, (E)MONOMEROS CON GRUPOS ZWITTERIONICOS. LOS MONOMEROS PUEDEN PROPORCIONARSE ADICIONALMENTE CON PROPIEDADES ANTITROMBOGENICAS, INCLUYENDO UN MONOMERO ADICIONAL CON UN GRUPO DE HEPARINA PENDIENTE (O HIRULINA, WARFARINA O ACIDO HIALURONICO). LOS PORIMEROS PUEDEN UTILIZARSE COMO MATERIALES DE RECUBRIMIENTO PARA DISPOSITIVOS MEDICOS, TALES COMO TUBOS O CONECTORES, CON EL FIN DE DOTARLOS CON PROPIEDADES NO TROMBOGENICAS Y, OPCIONALMENTE ANTITROMBOGENICAS.
ES97918264T 1996-04-30 1997-04-30 Polimeros no trombogenos y anti-trombogenos. Expired - Lifetime ES2143859T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9608882.8A GB9608882D0 (en) 1996-04-30 1996-04-30 Non-thrombogenic and anti-thrombogenic polymers
US09/185,701 US6406687B1 (en) 1996-04-30 1998-11-04 Non-thrombogenic and anti-thrombogenic polymers

Publications (1)

Publication Number Publication Date
ES2143859T3 true ES2143859T3 (es) 2000-05-16

Family

ID=26309228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97918264T Expired - Lifetime ES2143859T3 (es) 1996-04-30 1997-04-30 Polimeros no trombogenos y anti-trombogenos.

Country Status (12)

Country Link
US (2) US6096798A (es)
EP (1) EP0896600B1 (es)
JP (1) JP4195726B2 (es)
AT (1) ATE188713T1 (es)
AU (1) AU727181B2 (es)
CA (1) CA2252597C (es)
DE (1) DE69701140T2 (es)
ES (1) ES2143859T3 (es)
GB (1) GB9608882D0 (es)
GR (1) GR3033140T3 (es)
PT (1) PT896600E (es)
WO (1) WO1997041164A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034061B1 (en) * 1996-04-30 2006-04-25 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers
GB9608882D0 (en) * 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US6478808B2 (en) 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
GB2347861B (en) * 1999-03-13 2003-11-26 Biointeractions Ltd Biocompatible endoprostheses
ES2154242B1 (es) * 1999-09-03 2001-10-16 Uriach & Cia Sa J Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb.
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
US7015262B2 (en) * 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US8227411B2 (en) 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7981862B2 (en) 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7468210B1 (en) 2002-12-10 2008-12-23 Biosurface Engineering Technologies, Inc. Cross-linked heparin coatings and methods
EP1603603B1 (en) 2003-02-28 2014-11-19 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US8791171B2 (en) 2003-05-01 2014-07-29 Abbott Cardiovascular Systems Inc. Biodegradable coatings for implantable medical devices
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
WO2005082005A2 (en) 2004-02-20 2005-09-09 Biosurface Engineering Technologies, Inc., Et Al. Positive modulator of bone morphogenic protein-2
US7244443B2 (en) 2004-08-31 2007-07-17 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
US9297928B2 (en) 2004-11-22 2016-03-29 Johnson & Johnson Vision Care, Inc. Ophthalmic compositions comprising polyether substituted polymers
US8496953B2 (en) * 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US9114194B2 (en) * 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
US10188826B2 (en) * 2006-09-29 2019-01-29 Covidien Lp Catheters including antimicrobial sleeve and methods of making catheters
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
US8541498B2 (en) 2010-09-08 2013-09-24 Biointeractions Ltd. Lubricious coatings for medical devices
CN105664252B (zh) 2011-03-11 2019-11-19 W.L.戈尔及同仁股份有限公司 固定的生物实体的改进
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
EP2741806B1 (en) 2011-08-11 2018-11-07 Medical Components, Inc. Apparatus for the dialysis of blood
CA3105565C (en) 2013-04-26 2023-03-07 Biointeractions Limited Bioactive coatings
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
USD905853S1 (en) 2018-02-27 2020-12-22 Medical Components, Inc. Catheter tip
CN111184914B (zh) * 2020-02-17 2021-10-15 四川大学 一种功能化脱细胞基质生物材料及其制备方法和应用
USD984880S1 (en) 2020-11-06 2023-05-02 Medical Components, Inc. Clamp with indicator

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3086959A (en) * 1957-11-25 1963-04-23 Dow Chemical Co Graft copolymers of certain monomeric sulfonic acid compounds on certain nu-vinyl-2-oxazolidinone copolymer substrates and improved acrylonitrile polymer compositions obtainable therewith
BE573256A (es) * 1957-11-25
JPS53126093A (en) * 1977-04-12 1978-11-02 Japan Exlan Co Ltd Preparation of aqueous polymer emulsion having modified stability
FR2461724A1 (fr) 1979-07-20 1981-02-06 Christine Fougnot Polymeres substitues par des groupes leur conferant des proprietes anti-coagulantes et leur procede de preparation, objets constitues par et/ou comprenant lesdits polymeres et leurs procedes de fabrication, application desdits objets en chirurgie et en medecine, et compositions pharmaceutiques contenant lesdits polymeres substitues
EP0124676A1 (en) * 1983-05-04 1984-11-14 IRD-Biomaterial AB A surface modified solid substrate and a method for its preparation
US4521564A (en) 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
SE444950B (sv) 1984-09-28 1986-05-20 Ytkemiska Inst Ytbelagd artikel, forfarande och medel for framstellning derav samt anvendning derav
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
KR940003440Y1 (ko) * 1989-06-21 1994-05-25 대우전자 주식회사 오디오(Audio)용 회전헤드(Head)의 조작판 출몰장치
US5216087A (en) 1989-06-14 1993-06-01 Korea Institute Of Science And Technology Process for the preparation of sulfonated polyethyleneoxide-substituted polymers with improved blood compatibility
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
SE470006B (sv) 1991-09-26 1993-10-25 Corline Systems Ab Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
KR0131046B1 (ko) 1994-07-13 1998-04-14 김은영 항석회화 생체 조직 인공 심장 판막
GB9608882D0 (en) 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers

Also Published As

Publication number Publication date
DE69701140T2 (de) 2000-07-13
JP4195726B2 (ja) 2008-12-10
EP0896600A1 (en) 1999-02-17
AU2645997A (en) 1997-11-19
PT896600E (pt) 2000-04-28
CA2252597A1 (en) 1997-11-06
CA2252597C (en) 2006-12-19
ATE188713T1 (de) 2000-01-15
WO1997041164A1 (en) 1997-11-06
GB9608882D0 (en) 1996-07-03
EP0896600B1 (en) 2000-01-12
DE69701140D1 (de) 2000-02-17
US6096798A (en) 2000-08-01
GR3033140T3 (en) 2000-08-31
US6406687B1 (en) 2002-06-18
JP2000510882A (ja) 2000-08-22
AU727181B2 (en) 2000-12-07

Similar Documents

Publication Publication Date Title
ES2143859T3 (es) Polimeros no trombogenos y anti-trombogenos.
EP0183989A3 (en) Fluorine-containing graft copolymer and adhesive and composite membrane made thereof
DK0772514T3 (da) Selvrensende overflader af genstande samt fremgangsmåde til fremstilling deraf
CA2156527A1 (en) Microemulsion Polymerization Systems and Coated Materials Made Therefrom
MX9307314A (es) Metodo para formar fibras de polimeros de poliolefina y producto resultante.
BR9100758A (pt) Conector ótico orientável para o coligamento de fibras óticas com componentes óticos discretos, e sensor utilizando um ou mais conectores orientáveis
FI962998A (fi) Biohajoavia 3-polymeerihydroksibutyraatti/3-polyhydroksiheksanoaatti-kopolymeerikalvoja
BR9905808A (pt) Polìmero de emulsão aquosa de múltiplos estágios, e, processo para proporcionar um revestimento resistente à captação de sujeira
CO5040162A1 (es) Procedimiento para la preparacion de una dispersion acuosa de polimeros fluorados con diverso tamano de particulas y ta les dispersiones acuosas
BR0012087A (pt) Composições compreendendo copolìmeros em bloco hidrogenados e aplicações de uso final dos mesmos
ATE281475T1 (de) Polymere mit thermoverdickungs-eigenschaften und verfahren zu deren herstellung
FR2704431B1 (fr) Utilisation d'hydrogels à base d'acide hyaluronique et/ou de polydésoxyribonucléotides comme matériaux de remplissage de prothèses et prothèses en résultant.
BR0012219A (pt) Composições compreendendo copolìmeros em bloco hidrogenados e aplicações de uso final para as mesmas
IT8521350A0 (it) Fibra ottiva avente un'anima di polimetacrilato e un rivestimentodi fluoro copolimero.
CA2294731A1 (en) Block copolymer
DK0868437T3 (da) Fremgangsmåde til fremstilling af hyaluronsyrefraktion med et lavt polydispersionsindeks
DE69112420D1 (de) Makromolekulare monomere aus lebenden polymeren.
FI971643A0 (fi) Monityydyttymättömät hiilihydraattijohdannaiset, niiden polymeerit ja niiden käyttö
DE3766276D1 (de) Gegen abblaettern bestaendige polymerzusammensetzung, sowie beschichtung.
MY116691A (en) Compositions crosslinkable with an aliphatic polycarbodiimide
CA2171666A1 (en) Improved cured composite and process therefor
DE69200108D1 (de) Polymerviskositätsindexverbesserer.
ES2084754T3 (es) Polimeros de estireno expandibles con una elevada expansibilidad.
EP0298664A3 (en) Polymer compositions of fluorine-containing polymers and acrylic polymers
ATE118802T1 (de) Homogene polymermischungen aus polymetacrylimid- polymeren.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 896600

Country of ref document: ES