ES2140412T3 - Procedimiento para la obtencion de espiroacetales. - Google Patents

Procedimiento para la obtencion de espiroacetales.

Info

Publication number
ES2140412T3
ES2140412T3 ES92915480T ES92915480T ES2140412T3 ES 2140412 T3 ES2140412 T3 ES 2140412T3 ES 92915480 T ES92915480 T ES 92915480T ES 92915480 T ES92915480 T ES 92915480T ES 2140412 T3 ES2140412 T3 ES 2140412T3
Authority
ES
Spain
Prior art keywords
formation
general formula
iii
sulfur
coch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915480T
Other languages
English (en)
Inventor
Da Costa Maria Do Ce Goncalves
De Oliveira Baptista Mar Vidal
Loureiro Da Silva Tavares D De
William Branks Motherwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Givaudan Roure International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan Roure International SA filed Critical Givaudan Roure International SA
Application granted granted Critical
Publication of ES2140412T3 publication Critical patent/ES2140412T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/21—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PRODUCCION DE ESPIROCETALES LABDANO DEL TIPO AMBAR GRIS DE LA FORMULA GENERAL (I) Y (II), DONDE R REPRESENTA OXIGENO O AZUFRE, UTILIZADO EN LA INDUSTRIA DE PERFUMARIA, SIENDO CARACTERIZADO EL MENCIONADO PROCESO MEDIANTE LA CICLISACION INTRAMOLECULAR DE EPOXICETONA O SUS TIOANALOGOS DE LA FORMULA GENERAL (III), DONDE R1 REPRESENTA COCH3 Y R2 OXIGENO O AZUFRE. LOS MATERIALES DE PARTIDA SON OBTENIDOS MEDIANTE UNA ETAPA DE OXIDACION DE DITERPENOS LABDANO DE LA FORMULA GENERAL (IV), DONDE R ES UN ALCOHOL ARIL TERCIARIO O ACIDO VINIL, ESTERIFICADO OPCIONALMENTE CON UN GRUPO ALQUIL, PARA LA FORMACION DE UNA CETONA METIL INTERMEDIA DE LA FORMULA (V), DONDE R = COCH3, CON RENDIMIENTO MAS ALTO DEL 60 % SEGUIDO MEDIANTE UNA ETAPA DE EPOXIDACION CON PERACIDO, CON RIQUEZA NO INFERIOR AL 80 % DE LA EPOXICETONA III ASI OBTENIDA, Y FINALMENTE, MEDIANTE TRATAMIENTO DE III CON VARIOS CATALIZADORES, EN MEDIOS HOMOGENEOS O HETEROGENEOS, DEPENDIENDO LA ELECCION DEL CATALIZADOS DELA SELECTIVIDAD DESEADA, QUE PUEDE ALCANZAR EL 100 % DE I O 100 % DE II O CONDUCIDO A MEZCLAS ENRIQUECIDAS EN EL ESPIROCETAL II OLOROSO.
ES92915480T 1991-07-17 1992-07-15 Procedimiento para la obtencion de espiroacetales. Expired - Lifetime ES2140412T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT98344A PT98344B (pt) 1991-07-17 1991-07-17 Processo para a obtencao de espirocetais labdanicos do tipo ambar cinzento

Publications (1)

Publication Number Publication Date
ES2140412T3 true ES2140412T3 (es) 2000-03-01

Family

ID=20084984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915480T Expired - Lifetime ES2140412T3 (es) 1991-07-17 1992-07-15 Procedimiento para la obtencion de espiroacetales.

Country Status (7)

Country Link
US (1) US5440050A (es)
EP (1) EP0553314B1 (es)
JP (1) JP3157831B2 (es)
DE (1) DE69230283T2 (es)
ES (1) ES2140412T3 (es)
PT (1) PT98344B (es)
WO (1) WO1993002084A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441610A (en) * 1992-02-28 1995-08-15 Renlund; Gary M. Oxygen supply and removal method and apparatus
US7294492B2 (en) * 2005-01-07 2007-11-13 International Flavors & Fragrances Inc. Process for the manufacture of spiroketals
TW201011043A (en) 2008-06-20 2010-03-16 Chugai Pharmaceutical Co Ltd Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives
GB201020070D0 (en) * 2010-11-26 2011-01-12 Givaudan Sa Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144465A (en) * 1961-01-12 1964-08-11 Firmenich & Cie Internal ketals from dihydro-gammaionone, dihydro-gamma-irone and 5, 5, 9-trimethyl-2-methylene-1-(3'-oxobutyl-1')-decahydronaphthalene
CH428765A (fr) * 1961-01-12 1967-01-31 Firmenich & Cie Procédé pour la préparation de cétals internes polycycliques
US4276216A (en) * 1980-07-31 1981-06-30 Ortho Pharmaceutical Corporation Synthesis of dioxabicyclo[3.2.1]octanes and oxepanes

Also Published As

Publication number Publication date
WO1993002084A1 (en) 1993-02-04
JP3157831B2 (ja) 2001-04-16
US5440050A (en) 1995-08-08
DE69230283D1 (de) 1999-12-16
DE69230283T2 (de) 2000-07-13
EP0553314A1 (en) 1993-08-04
EP0553314B1 (en) 1999-11-10
PT98344A (pt) 1993-01-29
JPH06502193A (ja) 1994-03-10
PT98344B (pt) 1999-04-30

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