ES2139597T3 - Uso de s-nitrosotioles para la preparacion de un medicamento para la relajacion del musculo liso. - Google Patents
Uso de s-nitrosotioles para la preparacion de un medicamento para la relajacion del musculo liso.Info
- Publication number
- ES2139597T3 ES2139597T3 ES92909921T ES92909921T ES2139597T3 ES 2139597 T3 ES2139597 T3 ES 2139597T3 ES 92909921 T ES92909921 T ES 92909921T ES 92909921 T ES92909921 T ES 92909921T ES 2139597 T3 ES2139597 T3 ES 2139597T3
- Authority
- ES
- Spain
- Prior art keywords
- smooth muscle
- nitrosothiols
- relaxation
- nitrosotiols
- medication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
LOS S-NITROSOTIOLES EJERCEN UN POTENTE EFECTO RELAJANTE, MEDIADO POR LA CICLASA DE GUANILATOS, EN LOS MUSCULOS TERSOS NO VASCULARES. ENTRE TALES TIPOS DE MUSCULOS TERSOS CABE INCLUIR A LOS DE LAS VIAS RESPIRATORIAS, GASTROINTESTINALES, LA VEJIGA, EL UTERO Y EL CUERPO CAVERNOSO. DE ESTE MODO, LOS S-NITROSOTIOLES SE PUEDEN UTILIZAR PARA EL TRATAMIENTO O PREVENCION DE LOS TRASTORNOS ASOCIADOS A LA RELAJACION DE LOS MUSCULOS, TALES COMO LA OBSTRUCCION DE LAS VIAS RESPIRATORIAS Y OTROS TRASTORNOS RESPIRATORIOS, LA DISFUNCION DE LA VEJIGA, EL PARTO PREMATURO Y LA IMPOTENCIA. ADICIONALMENTE, LOS SNITROSOTIOLES SE PUEDEN UTILIZAR PARA ALIVIAR LA CONTRACCION DE LOS MUSCULOS TERSOS Y LOS ESPASMOS Y FACILITAR ASI LAS PRACTICAS EN LAS QUE SE UTILIZAN INSTRUMENTOS DE DIAGNOSTICO TALES COMO LA ENDOSCOPIA, BRONCOSCOPIA, LAPAROSCOPIA Y CITOSCOPIA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67669191A | 1991-03-29 | 1991-03-29 | |
US80466591A | 1991-12-11 | 1991-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2139597T3 true ES2139597T3 (es) | 2000-02-16 |
Family
ID=27101601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92909921T Expired - Lifetime ES2139597T3 (es) | 1991-03-29 | 1992-03-30 | Uso de s-nitrosotioles para la preparacion de un medicamento para la relajacion del musculo liso. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0582631B1 (es) |
JP (1) | JPH06506222A (es) |
AT (1) | ATE187064T1 (es) |
AU (2) | AU1685292A (es) |
CA (1) | CA2107219C (es) |
DE (1) | DE69230373T2 (es) |
DK (1) | DK0582631T3 (es) |
ES (1) | ES2139597T3 (es) |
GR (1) | GR3032351T3 (es) |
IL (1) | IL101406A (es) |
WO (1) | WO1992017445A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
DK0560928T3 (da) * | 1990-12-05 | 1997-12-01 | Gen Hospital Corp | Anordninger til behandling af pulmonal vasokonstriktion og astma |
US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5583101A (en) * | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US5823180A (en) * | 1995-04-03 | 1998-10-20 | The General Hospital Corporation | Methods for treating pulmonary vasoconstriction and asthma |
US5612314A (en) * | 1995-04-21 | 1997-03-18 | Brigham & Women's Hospital | Nitrosylated neuropeptides |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US6617355B1 (en) * | 1997-05-21 | 2003-09-09 | The University Of Virginia Patent Foundation | Treating asthma by preventing and/or accomodating S-nitrosothiol breakdown |
US6207855B1 (en) | 1998-06-23 | 2001-03-27 | Duke University Medical Center | Stable no-delivering compounds |
WO2003015605A2 (en) * | 2001-08-20 | 2003-02-27 | University Of Virginia Patent Foundation | Use of s-nitrosothiol signaling to treat disordered control of breathing |
WO2018132371A2 (en) | 2017-01-10 | 2018-07-19 | United Therapeutics Corporation | Methods and compositions for treating pulmonary hypertension |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US676691A (en) | 1901-02-02 | 1901-06-18 | Rudolph Federroll | Acetylene-gas generator. |
US2328709A (en) * | 1940-06-27 | 1943-09-07 | Socony Vacuum Oil Co Inc | Method for stabilizing organic thionitrites |
US5002964A (en) * | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
US4900719A (en) * | 1988-08-05 | 1990-02-13 | The Ohio State University | Nitrosothiols as hypotensive agents |
DE69008454T2 (de) * | 1989-08-07 | 1994-08-25 | Takeda Chemical Industries Ltd | Nitrolsothiolderivate, ihre Herstellung und Verwendung. |
-
1992
- 1992-03-29 IL IL101406A patent/IL101406A/en not_active IP Right Cessation
- 1992-03-30 AU AU16852/92A patent/AU1685292A/en not_active Abandoned
- 1992-03-30 JP JP4509090A patent/JPH06506222A/ja active Pending
- 1992-03-30 CA CA002107219A patent/CA2107219C/en not_active Expired - Lifetime
- 1992-03-30 DE DE69230373T patent/DE69230373T2/de not_active Expired - Fee Related
- 1992-03-30 AT AT92909921T patent/ATE187064T1/de not_active IP Right Cessation
- 1992-03-30 DK DK92909921T patent/DK0582631T3/da active
- 1992-03-30 WO PCT/US1992/002560 patent/WO1992017445A2/en active IP Right Grant
- 1992-03-30 ES ES92909921T patent/ES2139597T3/es not_active Expired - Lifetime
- 1992-03-30 EP EP92909921A patent/EP0582631B1/en not_active Expired - Lifetime
-
1996
- 1996-05-29 AU AU54590/96A patent/AU702429B2/en not_active Ceased
-
2000
- 2000-01-13 GR GR20000400047T patent/GR3032351T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1992017445A2 (en) | 1992-10-15 |
WO1992017445A3 (en) | 1992-12-10 |
EP0582631A4 (en) | 1994-07-06 |
JPH06506222A (ja) | 1994-07-14 |
EP0582631A1 (en) | 1994-02-16 |
AU1685292A (en) | 1992-11-02 |
CA2107219C (en) | 2003-09-16 |
DE69230373T2 (de) | 2000-08-24 |
GR3032351T3 (en) | 2000-04-27 |
AU5459096A (en) | 1996-08-01 |
EP0582631B1 (en) | 1999-12-01 |
AU702429B2 (en) | 1999-02-18 |
IL101406A (en) | 1998-02-08 |
DE69230373D1 (de) | 2000-01-05 |
CA2107219A1 (en) | 1992-09-30 |
ATE187064T1 (de) | 1999-12-15 |
DK0582631T3 (da) | 2000-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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