ATE187064T1 - Verwendung von s-nitrosothiolen zur herstellung eines arzneimittels zur entspannung von glatter muskulatur - Google Patents

Verwendung von s-nitrosothiolen zur herstellung eines arzneimittels zur entspannung von glatter muskulatur

Info

Publication number
ATE187064T1
ATE187064T1 AT92909921T AT92909921T ATE187064T1 AT E187064 T1 ATE187064 T1 AT E187064T1 AT 92909921 T AT92909921 T AT 92909921T AT 92909921 T AT92909921 T AT 92909921T AT E187064 T1 ATE187064 T1 AT E187064T1
Authority
AT
Austria
Prior art keywords
nitrosothiols
smooth muscle
producing
medicinal product
smooth muscles
Prior art date
Application number
AT92909921T
Other languages
English (en)
Inventor
Jonathan S Stamler
Joseph Loscalzo
Adam Slivka
Daniel Simon
Robert Brown
Jeffrey Drazen
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Application granted granted Critical
Publication of ATE187064T1 publication Critical patent/ATE187064T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AT92909921T 1991-03-29 1992-03-30 Verwendung von s-nitrosothiolen zur herstellung eines arzneimittels zur entspannung von glatter muskulatur ATE187064T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67669191A 1991-03-29 1991-03-29
US80466591A 1991-12-11 1991-12-11

Publications (1)

Publication Number Publication Date
ATE187064T1 true ATE187064T1 (de) 1999-12-15

Family

ID=27101601

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92909921T ATE187064T1 (de) 1991-03-29 1992-03-30 Verwendung von s-nitrosothiolen zur herstellung eines arzneimittels zur entspannung von glatter muskulatur

Country Status (11)

Country Link
EP (1) EP0582631B1 (de)
JP (1) JPH06506222A (de)
AT (1) ATE187064T1 (de)
AU (2) AU1685292A (de)
CA (1) CA2107219C (de)
DE (1) DE69230373T2 (de)
DK (1) DK0582631T3 (de)
ES (1) ES2139597T3 (de)
GR (1) GR3032351T3 (de)
IL (1) IL101406A (de)
WO (1) WO1992017445A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536241A (en) * 1990-12-05 1996-07-16 The General Hospital Corporation Methods and devices for relaxing smooth muscle contractions
US5570683A (en) * 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
DE10299002I1 (de) * 1990-12-05 2012-07-05 Gen Hospital Corp Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5583101A (en) * 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
US6063407A (en) * 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5823180A (en) * 1995-04-03 1998-10-20 The General Hospital Corporation Methods for treating pulmonary vasoconstriction and asthma
US5612314A (en) * 1995-04-21 1997-03-18 Brigham & Women's Hospital Nitrosylated neuropeptides
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US6232434B1 (en) * 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
WO1998052580A1 (en) * 1997-05-21 1998-11-26 Duke University Treating asthma by preventing and/or accommodating for s-nitrosothiol breakdown
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
AU2002326573B2 (en) * 2001-08-20 2008-10-02 University Of Louisville Research Foundation, Inc. Use of S-nitrosothiol signaling to treat disordered control of breathing
US20180325908A1 (en) 2017-01-10 2018-11-15 United Therapeutics Corporation Methods and compositions for treating pulmonary hypertension

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US676691A (en) 1901-02-02 1901-06-18 Rudolph Federroll Acetylene-gas generator.
US2328709A (en) * 1940-06-27 1943-09-07 Socony Vacuum Oil Co Inc Method for stabilizing organic thionitrites
US5002964A (en) 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof
US4900719A (en) * 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
DE69008454T2 (de) * 1989-08-07 1994-08-25 Takeda Chemical Industries Ltd Nitrolsothiolderivate, ihre Herstellung und Verwendung.

Also Published As

Publication number Publication date
CA2107219A1 (en) 1992-09-30
AU1685292A (en) 1992-11-02
AU702429B2 (en) 1999-02-18
CA2107219C (en) 2003-09-16
ES2139597T3 (es) 2000-02-16
GR3032351T3 (en) 2000-04-27
DK0582631T3 (da) 2000-04-25
AU5459096A (en) 1996-08-01
EP0582631A1 (de) 1994-02-16
JPH06506222A (ja) 1994-07-14
WO1992017445A2 (en) 1992-10-15
EP0582631B1 (de) 1999-12-01
DE69230373T2 (de) 2000-08-24
DE69230373D1 (de) 2000-01-05
EP0582631A4 (en) 1994-07-06
IL101406A (en) 1998-02-08
WO1992017445A3 (en) 1992-12-10

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee