ES2139347T3 - Ensayos rapidos para la valoracion del estado de organos basados en la deteccion de una o mas isoenzimas de glutation-s-transferasa. - Google Patents
Ensayos rapidos para la valoracion del estado de organos basados en la deteccion de una o mas isoenzimas de glutation-s-transferasa.Info
- Publication number
- ES2139347T3 ES2139347T3 ES96909321T ES96909321T ES2139347T3 ES 2139347 T3 ES2139347 T3 ES 2139347T3 ES 96909321 T ES96909321 T ES 96909321T ES 96909321 T ES96909321 T ES 96909321T ES 2139347 T3 ES2139347 T3 ES 2139347T3
- Authority
- ES
- Spain
- Prior art keywords
- detection
- glutation
- isoenzymes
- assessment
- status based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010044467 Isoenzymes Proteins 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title abstract 3
- 210000000056 organ Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000013060 biological fluid Substances 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000002110 toxicologic effect Effects 0.000 abstract 1
- 231100000027 toxicology Toxicity 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
- G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
- G01N2333/91182—Enolpyruvylshikimate-phosphate synthases (2.5.1.19)
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA EVALUACION RAPIDA DEL ESTADO DE ORGANOS, INCLUYENDO LAS LESIONES EN ORGANOS DESPUES DE UN ATAQUE INMUNOLOGICO O TOXICOLOGICO EN UN SUJETO, BASADO EN LA DETECCION DE UNA O MAS ISOENZIMAS DE GLUTATION S FERASA (GST) EN DIVERSOS FLUIDOS BIOLOGICOS QUE INCLUYE PONER EN CONTACTO UN ANTICUERPO ANTI ESPECIFICO PARA DICHA ISOENZIMA, CON UNA MUESTRA DE UN FLUIDO BIOLOGICO DEL CUAL SE SOSPECHA QUE CONTIENE DICHA ISOENZIMA, TENIENDO DICHO ANTICUERPO UNA SENSIBILIDAD SUFICIENTE PARA DETECTAR AL MENOS UNA CANTIDAD PICOMOLAR DE DICHA ISOENZIMA, Y CAPTURAR EL COMPLEJO ISOENZIMA CULA SOBRE UN ANTICUERPO DE CAPTURA INMOVILIZADO, PARA GENERAR UNA SEÑAL DETECTABLE DE FORMA VISUAL. EL PROCEDIMIENTO PERMITE LA DETECCION O LA DETERMINACION DE ISOENZIMAS GST EN UN TIEMPO TIPICO DEL ORDEN DE 30 MINUTOS DESDE EL CONTACTO INICIAL CON EL ANTICUERPO ANTI LLO DE UTILIZAR Y POR TANTO PUEDE USARSE, POR EJEMPLO, POR LOS PACIENTES EN SU HOGAR PARA CONTROLAR SUS NIVELES DE UNA ISOENZIMAGST CONCRETA DESPUES DE UN TRANSPLANTE HEPATICO O RENAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IE1995/000024 WO1996031778A1 (en) | 1995-04-03 | 1995-04-03 | Rapid assays for the detection of glutathione s-transferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2139347T3 true ES2139347T3 (es) | 2000-02-01 |
Family
ID=11042491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96909321T Expired - Lifetime ES2139347T3 (es) | 1995-04-03 | 1996-04-02 | Ensayos rapidos para la valoracion del estado de organos basados en la deteccion de una o mas isoenzimas de glutation-s-transferasa. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6080551A (es) |
| EP (1) | EP0819252B1 (es) |
| KR (1) | KR19980703302A (es) |
| CN (1) | CN1100994C (es) |
| AT (1) | ATE186986T1 (es) |
| AU (2) | AU2147295A (es) |
| BR (1) | BR9604836A (es) |
| CA (1) | CA2217296C (es) |
| CZ (1) | CZ287467B6 (es) |
| DE (1) | DE69605294T2 (es) |
| ES (1) | ES2139347T3 (es) |
| HU (1) | HUP9903485A2 (es) |
| NO (1) | NO974565L (es) |
| NZ (1) | NZ304977A (es) |
| PL (1) | PL322593A1 (es) |
| RU (1) | RU2154832C2 (es) |
| WO (2) | WO1996031778A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996031778A1 (en) * | 1995-04-03 | 1996-10-10 | Syncor Intellectual Properties Limited | Rapid assays for the detection of glutathione s-transferases |
| ATE213835T1 (de) * | 1995-12-08 | 2002-03-15 | Biotrin Intellectual Pty Ltd | Verfahren zur bestimmung und zum nachweis von spenderorganschäden nach xenotransplantation auf der grundlage von aus dem spenderorgan freigesetzten analyten |
| US6977140B1 (en) | 1998-09-29 | 2005-12-20 | Organ Recovery Systems, Inc. | Method for maintaining and/or restoring viability of organs |
| US6551790B2 (en) * | 1998-12-07 | 2003-04-22 | Panvera Llc | Process for glucuronidation screening |
| US20040146847A1 (en) * | 1998-12-07 | 2004-07-29 | Trubetskoy Olga V. | Process for glucuronidation screening |
| US6492103B1 (en) | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| WO2004055165A2 (en) * | 2002-12-13 | 2004-07-01 | St. Jude Children's Research Hospital | Glutathione-s-transferase test for susceptibility to parkinson's |
| FI20040205L (fi) * | 2004-02-11 | 2005-08-12 | Reagena Ltd Oy | Menetelmä ja laite pikatestin valmistamiseksi |
| US8741555B2 (en) | 2004-05-14 | 2014-06-03 | Organ Recovery Systems, Inc. | Apparatus and method for perfusion and determining the viability of an organ |
| US10176887B1 (en) | 2005-11-14 | 2019-01-08 | Organ Recovery Systems, Inc. | Ex vivo methods for drug discovery, development and testing |
| US8771930B2 (en) | 2007-05-18 | 2014-07-08 | Lifeline Scientific, Inc. | Ex vivo methods for testing toxicity of substances using donated human organs or tissues |
| US8765364B2 (en) | 2007-05-18 | 2014-07-01 | Lifeline Scientific, Inc. | Ex vivo methods for validating substance testing with human organs and/or tissues |
| EP2269068A1 (en) * | 2008-03-18 | 2011-01-05 | Argutus Intellectual Properties Limited | Method of assessing kidney function in a human subject |
| JP6371808B2 (ja) * | 2016-08-09 | 2018-08-08 | 積水メディカル株式会社 | イムノクロマトグラフィー検出キット |
| WO2018030365A1 (ja) * | 2016-08-09 | 2018-02-15 | 積水メディカル株式会社 | イムノクロマトグラフィー検出キット |
| EP4103944A4 (en) * | 2020-02-14 | 2024-04-24 | Galaxy CCRO, Inc | DEVICES AND METHODS FOR TREATING ISCHEMIA AND ACUTE RESPIRATORY DISTRESS SYNDROME |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE560410T1 (de) * | 1987-04-27 | 2001-12-20 | Unilever Nv | Testgerät zur Durchführung von spezifischen Bindungsprüfungen. |
| US5427917A (en) * | 1988-02-01 | 1995-06-27 | Teijin Limited | Method of determining human acid glutathione S-transferase, reagent, therefor, kit therefor, method of diagnosing cancer in digestive organs, and monoclonal antibody for use therein |
| AU5435990A (en) * | 1989-04-13 | 1990-11-05 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Monoclonal antibodies to human glutathione s transferase pi |
| US5217868A (en) * | 1992-05-01 | 1993-06-08 | Syncor Limited | Measurement of an enzyme marker as an aid to diagnosis of liver transplant rejection |
| WO1996031778A1 (en) * | 1995-04-03 | 1996-10-10 | Syncor Intellectual Properties Limited | Rapid assays for the detection of glutathione s-transferases |
-
1995
- 1995-04-03 WO PCT/IE1995/000024 patent/WO1996031778A1/en not_active Ceased
- 1995-04-03 AU AU21472/95A patent/AU2147295A/en not_active Withdrawn
-
1996
- 1996-04-02 BR BR9604836A patent/BR9604836A/pt not_active Application Discontinuation
- 1996-04-02 AU AU52868/96A patent/AU696996B2/en not_active Ceased
- 1996-04-02 EP EP96909321A patent/EP0819252B1/en not_active Expired - Lifetime
- 1996-04-02 HU HU9903485A patent/HUP9903485A2/hu unknown
- 1996-04-02 DE DE69605294T patent/DE69605294T2/de not_active Expired - Fee Related
- 1996-04-02 WO PCT/IE1996/000019 patent/WO1996031779A1/en not_active Ceased
- 1996-04-02 CA CA002217296A patent/CA2217296C/en not_active Expired - Fee Related
- 1996-04-02 RU RU97117933/14A patent/RU2154832C2/ru not_active IP Right Cessation
- 1996-04-02 US US08/930,511 patent/US6080551A/en not_active Expired - Lifetime
- 1996-04-02 AT AT96909321T patent/ATE186986T1/de not_active IP Right Cessation
- 1996-04-02 KR KR1019970706706A patent/KR19980703302A/ko not_active Withdrawn
- 1996-04-02 ES ES96909321T patent/ES2139347T3/es not_active Expired - Lifetime
- 1996-04-02 NZ NZ304977A patent/NZ304977A/en unknown
- 1996-04-02 CN CN96193068A patent/CN1100994C/zh not_active Expired - Fee Related
- 1996-04-02 CZ CZ19973009A patent/CZ287467B6/cs not_active IP Right Cessation
- 1996-04-02 PL PL96322593A patent/PL322593A1/xx unknown
-
1997
- 1997-10-02 NO NO974565A patent/NO974565L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996031778A1 (en) | 1996-10-10 |
| CN1100994C (zh) | 2003-02-05 |
| AU2147295A (en) | 1996-10-23 |
| US6080551A (en) | 2000-06-27 |
| NO974565L (no) | 1997-11-25 |
| PL322593A1 (en) | 1998-02-02 |
| EP0819252B1 (en) | 1999-11-24 |
| CZ287467B6 (en) | 2000-12-13 |
| DE69605294D1 (de) | 1999-12-30 |
| KR19980703302A (ko) | 1998-10-15 |
| HUP9903485A2 (hu) | 2000-12-28 |
| CA2217296A1 (en) | 1996-10-10 |
| AU5286896A (en) | 1996-10-23 |
| AU696996B2 (en) | 1998-09-24 |
| WO1996031779A1 (en) | 1996-10-10 |
| NZ304977A (en) | 1998-09-24 |
| BR9604836A (pt) | 1999-01-05 |
| CN1180411A (zh) | 1998-04-29 |
| ATE186986T1 (de) | 1999-12-15 |
| RU2154832C2 (ru) | 2000-08-20 |
| CA2217296C (en) | 2007-02-13 |
| DE69605294T2 (de) | 2000-04-27 |
| NO974565D0 (no) | 1997-10-02 |
| CZ300997A3 (cs) | 1998-06-17 |
| EP0819252A1 (en) | 1998-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Grant refused |
Effective date: 19960819 |
|
| FG2A | Definitive protection |
Ref document number: 819252 Country of ref document: ES |