ES2138937A1 - Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen. - Google Patents

Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.

Info

Publication number
ES2138937A1
ES2138937A1 ES009801426A ES9801426A ES2138937A1 ES 2138937 A1 ES2138937 A1 ES 2138937A1 ES 009801426 A ES009801426 A ES 009801426A ES 9801426 A ES9801426 A ES 9801426A ES 2138937 A1 ES2138937 A1 ES 2138937A1
Authority
ES
Spain
Prior art keywords
paroxetine maleate
pharmaceutical compositions
compositions containing
polymorph
paroxetine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009801426A
Other languages
English (en)
Other versions
ES2138937B1 (es
Inventor
Diez Del Corral Alberto Stampa
Llado Jordi Bosch
Grau Elias Molins
Miguel M Del Carmen Onrubia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES009801426A priority Critical patent/ES2138937B1/es
Priority to PCT/ES1999/000209 priority patent/WO2000001693A1/es
Priority to US09/743,047 priority patent/US6440459B1/en
Priority to AU45159/99A priority patent/AU4515999A/en
Publication of ES2138937A1 publication Critical patent/ES2138937A1/es
Application granted granted Critical
Publication of ES2138937B1 publication Critical patent/ES2138937B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Polimorfo de maleato de paroxetina y formulaciones Farmacéuticas que lo contienen. El nuevo polimorfo de maelato de paroxetina, Forma B presenta una estabilidad química sensiblemente más elevada que la Forma A de maleato de paroxetina conocida anteriormente. Esta superior estabilidad permite la utilización del nuevo polimorfo para la fabricación de medicamentos para el tratamiento de trastornos relacionados con disfunciones del sistema nervioso central y, consecuentemente, la obtención de nuevas formulaciones farmacéuticas que contiene dicho maleato de paroxetina en Forma B. Se describe también una utilización y un procedimiento de obtención de este maleato de paroxetina en Forma B. Figura 4.
ES009801426A 1998-07-07 1998-07-07 Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen. Expired - Fee Related ES2138937B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES009801426A ES2138937B1 (es) 1998-07-07 1998-07-07 Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
PCT/ES1999/000209 WO2000001693A1 (es) 1998-07-07 1999-07-05 Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen
US09/743,047 US6440459B1 (en) 1998-07-07 1999-07-05 Paroxetine maleate polymorph and pharmaceutical compositions containing it
AU45159/99A AU4515999A (en) 1998-07-07 1999-07-05 Paroxetine maleate polymorph and pharmaceutical compositions containing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801426A ES2138937B1 (es) 1998-07-07 1998-07-07 Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.

Publications (2)

Publication Number Publication Date
ES2138937A1 true ES2138937A1 (es) 2000-01-16
ES2138937B1 ES2138937B1 (es) 2000-10-01

Family

ID=8304415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009801426A Expired - Fee Related ES2138937B1 (es) 1998-07-07 1998-07-07 Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.

Country Status (4)

Country Link
US (1) US6440459B1 (es)
AU (1) AU4515999A (es)
ES (1) ES2138937B1 (es)
WO (1) WO2000001693A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9827387D0 (en) * 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
US20130071477A1 (en) 2011-09-19 2013-03-21 Orexo Ab New abuse-resistant pharmaceutical composition for the treatment of opioid dependence

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007196A (en) * 1973-01-30 1977-02-08 A/S Ferrosan 4-Phenylpiperidine compounds
EP0188081A2 (en) * 1984-12-04 1986-07-23 Novo Nordisk A/S Use of paroxetine for the manufacture of a medicament for the treatment of obesity
EP0269303A2 (en) * 1986-11-11 1988-06-01 Novo Nordisk A/S Piperidine derivative for treating pain
CA2187128A1 (en) * 1996-10-04 1997-06-26 K. S. Keshava Murthy New and useful polymorph of anhydrous paroxetine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058061T3 (es) 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
AR001982A1 (es) 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
CA2206592A1 (en) 1996-05-30 1997-11-30 Shu-Zhong Wang Method of producing amorphous paroxetine hydrochloride
US5672612A (en) 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007196A (en) * 1973-01-30 1977-02-08 A/S Ferrosan 4-Phenylpiperidine compounds
EP0188081A2 (en) * 1984-12-04 1986-07-23 Novo Nordisk A/S Use of paroxetine for the manufacture of a medicament for the treatment of obesity
EP0269303A2 (en) * 1986-11-11 1988-06-01 Novo Nordisk A/S Piperidine derivative for treating pain
CA2187128A1 (en) * 1996-10-04 1997-06-26 K. S. Keshava Murthy New and useful polymorph of anhydrous paroxetine hydrochloride

Also Published As

Publication number Publication date
ES2138937B1 (es) 2000-10-01
AU4515999A (en) 2000-01-24
US6440459B1 (en) 2002-08-27
WO2000001693A1 (es) 2000-01-13

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