ES2138902A1 - "5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2". - Google Patents
"5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2".Info
- Publication number
- ES2138902A1 ES2138902A1 ES009701063A ES9701063A ES2138902A1 ES 2138902 A1 ES2138902 A1 ES 2138902A1 ES 009701063 A ES009701063 A ES 009701063A ES 9701063 A ES9701063 A ES 9701063A ES 2138902 A1 ES2138902 A1 ES 2138902A1
- Authority
- ES
- Spain
- Prior art keywords
- cox
- arylthio
- products
- methyl
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
5-Ariltio-6-sulfonamido-3(2H)-benzofuranonas como inhibidores de la COX-2. Nuevos productos de fórmula (I),donde R es metilo y, o bien Ar es fenilo, 2-piridilo o 4-piridilo, opcionalmente sustituidos por metilo, etilo, propilo, isopropilo, trifluorometilo, fluoro, cloro, bromo, vinilo, metoxilo, trifluorometoxilo, metiltio, trifluorometiltio o ciano; o bien Ar es 2-tiazolilo o 2-oxazolilo, opcionalmente sustituidos por metilo, etilo, propilo e isopropilo. Los productos (I) se preparan por reacción de la correspondiente 5- ariltio-6-amino-3-(2H)-benzofuranona con cloruro de metanosulfonilo, seguida de hidrólisis, o por ciclación intramolecular de tipo Friedel-Crafts del cloruro del ácido 4-ariltio-3-metanosulfonamido- fenoxiacético correspondiente. Los productos (I) presentan actividad inhibidora de la COX-1 y la COX-2, con una selectividad respecto a la COX-2 mayor que la del producto de referencia L-745.337. Los productos (I) son útiles para el tratamiento de la inflamación o de las enfermedades mediadas por las ciclooxigenasas, con la ventaja adicional de poseer baja ulcerogenia.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701063A ES2138902B1 (es) | 1997-05-19 | 1997-05-19 | "5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2". |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701063A ES2138902B1 (es) | 1997-05-19 | 1997-05-19 | "5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2". |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2138902A1 true ES2138902A1 (es) | 2000-01-16 |
ES2138902B1 ES2138902B1 (es) | 2000-09-16 |
Family
ID=8299340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9701063A Expired - Fee Related ES2138902B1 (es) | 1997-05-19 | 1997-05-19 | "5-ariltio-6-sulfonamido-3(2h)-benzofuranonas como inhibidores de la cox-2". |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2138902B1 (es) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4244960A (en) * | 1978-07-27 | 1981-01-13 | Schering, Aktiengesellschaft | Indanyl derivatives and their use |
EP0078241A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Furane |
EP0078240A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Lactone |
US4411910A (en) * | 1981-03-11 | 1983-10-25 | Schering Aktiengesellschaft | Benzofuran derivatives and their pharmaceutical use |
ES8602735A1 (es) * | 1983-04-22 | 1985-12-01 | Ciba Geigy Ag | Procedimiento para la obtencion de benzofuranonas. |
WO1994013635A1 (en) * | 1992-12-11 | 1994-06-23 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
WO1994020480A1 (en) * | 1993-03-12 | 1994-09-15 | Merck Frosst Canada Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
WO1996023786A1 (en) * | 1995-01-31 | 1996-08-08 | Merck Frosst Canada Inc. | 5-methanesulfonamido-3h-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2 |
-
1997
- 1997-05-19 ES ES9701063A patent/ES2138902B1/es not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4244960A (en) * | 1978-07-27 | 1981-01-13 | Schering, Aktiengesellschaft | Indanyl derivatives and their use |
US4411910A (en) * | 1981-03-11 | 1983-10-25 | Schering Aktiengesellschaft | Benzofuran derivatives and their pharmaceutical use |
EP0078241A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Furane |
EP0078240A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Lactone |
ES8602735A1 (es) * | 1983-04-22 | 1985-12-01 | Ciba Geigy Ag | Procedimiento para la obtencion de benzofuranonas. |
WO1994013635A1 (en) * | 1992-12-11 | 1994-06-23 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
WO1994020480A1 (en) * | 1993-03-12 | 1994-09-15 | Merck Frosst Canada Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
WO1996023786A1 (en) * | 1995-01-31 | 1996-08-08 | Merck Frosst Canada Inc. | 5-methanesulfonamido-3h-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2 |
Also Published As
Publication number | Publication date |
---|---|
ES2138902B1 (es) | 2000-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20000116 Kind code of ref document: A1 Effective date: 20000116 |
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FD1A | Patent lapsed |
Effective date: 20040503 |