ES2137933T3 - Metodo para producir linfocitos t citotoxicos independientes de th. - Google Patents

Metodo para producir linfocitos t citotoxicos independientes de th.

Info

Publication number
ES2137933T3
ES2137933T3 ES91918388T ES91918388T ES2137933T3 ES 2137933 T3 ES2137933 T3 ES 2137933T3 ES 91918388 T ES91918388 T ES 91918388T ES 91918388 T ES91918388 T ES 91918388T ES 2137933 T3 ES2137933 T3 ES 2137933T3
Authority
ES
Spain
Prior art keywords
lymphocytes
cytotoxic
produce
ctl
independent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91918388T
Other languages
English (en)
Inventor
Philip D Greenberg
Robert W Overell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Fred Hutchinson Cancer Center
Original Assignee
Immunex Corp
Fred Hutchinson Cancer Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp, Fred Hutchinson Cancer Research Center filed Critical Immunex Corp
Application granted granted Critical
Publication of ES2137933T3 publication Critical patent/ES2137933T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LINFOCITOS T CITOTOXICOS (CTLS) QUE HAN SIDO CONVERTIDOS A CELULA T AUXILIADORA INDEPENDIENTE FENOTIPO MEDIANTE LA INTRODUCCION DE UN VECTOR DE EXPRESION RECOMBINANTE CODIFICADO IL-I RECEPTOR DENTRO DE CTL. LOS CTL RESULTANTES TIENEN LA CAPACIDAD DE CRECIMIENTO O FUNCION INDEPENDIENTE DE LA CELULA AUXILIADORA T.
ES91918388T 1990-09-28 1991-09-24 Metodo para producir linfocitos t citotoxicos independientes de th. Expired - Lifetime ES2137933T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58993990A 1990-09-28 1990-09-28
US61416790A 1990-11-09 1990-11-09

Publications (1)

Publication Number Publication Date
ES2137933T3 true ES2137933T3 (es) 2000-01-01

Family

ID=27080702

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91918388T Expired - Lifetime ES2137933T3 (es) 1990-09-28 1991-09-24 Metodo para producir linfocitos t citotoxicos independientes de th.

Country Status (10)

Country Link
EP (1) EP0553186B1 (es)
JP (1) JPH06503719A (es)
AT (1) ATE184050T1 (es)
AU (1) AU651397B2 (es)
CA (1) CA2092548A1 (es)
DE (1) DE69131577T2 (es)
DK (1) DK0553186T3 (es)
ES (1) ES2137933T3 (es)
GR (1) GR3031964T3 (es)
WO (1) WO1992005794A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0693940T3 (da) * 1993-04-06 2002-12-16 Targeted Genetics Corp Hybridgener til anvendelse til fremstilling af TH-uafhængige cytotoksiske T-celler
AU695869B2 (en) * 1993-04-06 1998-08-27 Fred Hutchinson Cancer Research Center Chimeric cytokine receptors in lymphocytes
US5827642A (en) * 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
JPH10505235A (ja) * 1994-08-31 1998-05-26 マックス−プランク−ゲゼルシャフト ツァー フォーダルング デア ビッセンシャッフェン イー．ブイ． 遺伝学的に改変されたｔ細胞
ES2203782T3 (es) 1996-01-17 2004-04-16 Imperial College Innovations Limited Inmunoterapia que utiliza linfocitos t citotoxicos (ctl).
US6316257B1 (en) 1996-03-04 2001-11-13 Targeted Genetics Corporation Modified rapid expansion methods (“modified-REM”) for in vitro propagation of T lymphocytes
WO1997032970A1 (en) * 1996-03-04 1997-09-12 Targeted Genetics Corporation Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes
US6562345B1 (en) 1996-11-12 2003-05-13 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
US6074645A (en) 1996-11-12 2000-06-13 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
US6156317A (en) * 1996-11-12 2000-12-05 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
US6544521B2 (en) 2000-10-20 2003-04-08 City Of Hope Immunoreactive peptide CTL epitopes of human cytomegalovirus pp150
CA3049656A1 (en) * 2017-01-10 2018-07-19 Nodus Therapeutics Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968607A (en) * 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
AU633287B2 (en) * 1988-12-15 1993-01-28 University Of Miami Lymphokine saf
WO1991018982A1 (en) * 1990-06-05 1991-12-12 Immunex Corporation Type ii interleukin-1 receptors

Also Published As

Publication number Publication date
ATE184050T1 (de) 1999-09-15
JPH06503719A (ja) 1994-04-28
DE69131577T2 (de) 2000-05-04
WO1992005794A1 (en) 1992-04-16
EP0553186A1 (en) 1993-08-04
GR3031964T3 (en) 2000-03-31
AU8851191A (en) 1992-04-28
EP0553186A4 (en) 1994-06-08
DE69131577D1 (de) 1999-10-07
EP0553186B1 (en) 1999-09-01
AU651397B2 (en) 1994-07-21
DK0553186T3 (da) 1999-11-29
CA2092548A1 (en) 1992-03-29

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