ES2137323T3 - Procedimiento de preparacion de derivados de bencilideno. - Google Patents
Procedimiento de preparacion de derivados de bencilideno.Info
- Publication number
- ES2137323T3 ES2137323T3 ES94303687T ES94303687T ES2137323T3 ES 2137323 T3 ES2137323 T3 ES 2137323T3 ES 94303687 T ES94303687 T ES 94303687T ES 94303687 T ES94303687 T ES 94303687T ES 2137323 T3 ES2137323 T3 ES 2137323T3
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- chem
- formula
- bencilideno
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/06—Six-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
UN METODO SELECTIVO PARA PRODUCIR DERIVADOS DE BENCILIDENO ESTEREOISOMERICO DE LA FORMULA III DONDE R1 Y R2 CADA UNO INDEPENDIENTEMENTE ES ALQUILO INFERIOR, ALCOXI INFERIOR O HALOGENO; Y ES SO2, SO O CO; -A SUSTITUIDO; -BDEN FORMAR FENILENO OPCIONALMENTE SUSTITUIDO O ALQUENILENO INFERIOR OPCIONALMENTE SUSTITUIDO; Y R ES HIDROGENO, ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, CICLOALKILO, ALCOXI INFERIOR, HIDROXI, ARILO SUSTITUIDO OPCIONALMENTE ARIALQUILO OPCIONALMENTE SUSTITUIDO; ARILALQUILOXI OPCIONALMENTE SUSTITUIDO, ANILLO HETEROCICLICO O GRUPOS DE PROTECCION N, QUE CONSISTE EN REACCIONAR UN COMPUESTO DE LA FORMULA (I): DONDE R1 Y R2 SON COMO SE DEFINEN ANTERIORMENTE Y X ES ALCOXI INFERIOR O HALOGENO CON UN COMPUESTO DE LA FORMULA II DONDE Y, -A-, -BEFINEN EN PRESENCIA DE UNA BASE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12390993 | 1993-05-26 | ||
JP08443894A JP3507124B2 (ja) | 1993-05-26 | 1994-04-22 | ベンジリデン誘導体の製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2137323T3 true ES2137323T3 (es) | 1999-12-16 |
Family
ID=26425484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94303687T Expired - Lifetime ES2137323T3 (es) | 1993-05-26 | 1994-05-23 | Procedimiento de preparacion de derivados de bencilideno. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5463052A (es) |
EP (1) | EP0626377B1 (es) |
JP (1) | JP3507124B2 (es) |
KR (1) | KR100326788B1 (es) |
CN (1) | CN1044238C (es) |
AT (1) | ATE182589T1 (es) |
AU (1) | AU674739B2 (es) |
CA (1) | CA2124136C (es) |
DE (1) | DE69419662T2 (es) |
DK (1) | DK0626377T3 (es) |
ES (1) | ES2137323T3 (es) |
GR (1) | GR3031470T3 (es) |
HU (1) | HU217088B (es) |
NO (1) | NO303117B1 (es) |
TW (1) | TW290539B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
WO2001060814A2 (en) * | 2000-02-15 | 2001-08-23 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
US6642232B2 (en) | 2001-10-10 | 2003-11-04 | Sugen, Inc. | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors |
CN103012254A (zh) | 2005-05-10 | 2013-04-03 | 英特芒尼公司 | 用于调节应激-活化蛋白激酶系统的吡啶酮衍生物 |
DE102007052891A1 (de) * | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Stabilisierung von olefinisch ungesättigten Monomeren |
CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
DE102009002514A1 (de) * | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
DE102013204950A1 (de) | 2013-03-20 | 2014-09-25 | Evonik Industries Ag | Verfahren und Zusammensetzung zur Inhibierung der Polymerisation von Cyclopentadienverbindungen |
MX2016012808A (es) | 2014-04-02 | 2017-01-05 | Intermune Inc | Piridinonas anti-fibroticas. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4892870A (en) * | 1988-08-01 | 1990-01-09 | Biofor, Ltd. | Oxaza heterocycles and pharmaceutical compositions containing same |
US5093363A (en) * | 1989-08-22 | 1992-03-03 | Shionogi & Co., Ltd. | 2,4,6-substituted phenol derivatives |
TW224461B (es) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag | |
WO1992012966A1 (fr) * | 1991-01-21 | 1992-08-06 | Shionogi Seiyaku Kabushiki Kaisha | Analogue de 3-benzylidene-1-carbamoyl-2-pyrrolidone |
ATE135697T1 (de) * | 1992-10-28 | 1996-04-15 | Shionogi & Co | Benzylidenderivate |
-
1994
- 1994-04-22 JP JP08443894A patent/JP3507124B2/ja not_active Expired - Fee Related
- 1994-05-19 TW TW083104536A patent/TW290539B/zh active
- 1994-05-20 US US08/246,494 patent/US5463052A/en not_active Expired - Fee Related
- 1994-05-23 ES ES94303687T patent/ES2137323T3/es not_active Expired - Lifetime
- 1994-05-23 DK DK94303687T patent/DK0626377T3/da active
- 1994-05-23 EP EP94303687A patent/EP0626377B1/en not_active Expired - Lifetime
- 1994-05-23 DE DE69419662T patent/DE69419662T2/de not_active Expired - Fee Related
- 1994-05-23 AT AT94303687T patent/ATE182589T1/de not_active IP Right Cessation
- 1994-05-24 CA CA002124136A patent/CA2124136C/en not_active Expired - Fee Related
- 1994-05-25 KR KR1019940011338A patent/KR100326788B1/ko not_active IP Right Cessation
- 1994-05-25 NO NO941934A patent/NO303117B1/no unknown
- 1994-05-25 HU HU9401569A patent/HU217088B/hu not_active IP Right Cessation
- 1994-05-26 CN CN94105933A patent/CN1044238C/zh not_active Expired - Fee Related
- 1994-05-26 AU AU63351/94A patent/AU674739B2/en not_active Ceased
-
1999
- 1999-10-08 GR GR990402561T patent/GR3031470T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CN1099751A (zh) | 1995-03-08 |
TW290539B (es) | 1996-11-11 |
GR3031470T3 (en) | 2000-01-31 |
AU674739B2 (en) | 1997-01-09 |
DK0626377T3 (da) | 2000-02-21 |
US5463052A (en) | 1995-10-31 |
ATE182589T1 (de) | 1999-08-15 |
DE69419662T2 (de) | 2000-01-27 |
EP0626377A1 (en) | 1994-11-30 |
EP0626377B1 (en) | 1999-07-28 |
AU6335194A (en) | 1994-12-01 |
JPH0741470A (ja) | 1995-02-10 |
NO303117B1 (no) | 1998-06-02 |
CA2124136A1 (en) | 1994-11-27 |
DE69419662D1 (de) | 1999-09-02 |
JP3507124B2 (ja) | 2004-03-15 |
HU217088B (hu) | 1999-11-29 |
NO941934D0 (no) | 1994-05-25 |
NO941934L (no) | 1994-11-28 |
HU9401569D0 (en) | 1994-08-29 |
KR100326788B1 (ko) | 2002-06-20 |
CN1044238C (zh) | 1999-07-21 |
CA2124136C (en) | 2004-07-27 |
HUT70841A (en) | 1995-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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