ES2136088T3 - Compuestos inmunogenos con efecto principalmente anti-citoquina, procedimiento de preparacion, composiciones farmaceuticas y kits que los contienen. - Google Patents
Compuestos inmunogenos con efecto principalmente anti-citoquina, procedimiento de preparacion, composiciones farmaceuticas y kits que los contienen.Info
- Publication number
- ES2136088T3 ES2136088T3 ES92912431T ES92912431T ES2136088T3 ES 2136088 T3 ES2136088 T3 ES 2136088T3 ES 92912431 T ES92912431 T ES 92912431T ES 92912431 T ES92912431 T ES 92912431T ES 2136088 T3 ES2136088 T3 ES 2136088T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- preparation procedure
- kits containing
- main anti
- immunogenic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000003092 anti-cytokine Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002163 immunogen Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011282 treatment Methods 0.000 abstract 3
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16061—Methods of inactivation or attenuation
- C12N2740/16063—Methods of inactivation or attenuation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
CITOQUINAS BAJO FORMA INMUNOGENA, INACTIVADAS O ANALOGOS INACTIVOS, O FRAGMENTOS INACTIVOS O INACTIVADOS DE CITOQUINA, PEPTIDOS INMUNOREGULADORES, VIRUS VACIADO DE SU GENOMA, PROCESOS DE PREPARACION, APLICACIONES COMO MEDICAMENTOS PARA TRATAMIENTO CURATIVO O PREVENTIVO, COMPOSICIONES FARMACEUTICAS Y KITS QUE LAS CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9107399A FR2677654B1 (fr) | 1991-06-17 | 1991-06-17 | Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2136088T3 true ES2136088T3 (es) | 1999-11-16 |
Family
ID=9413929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92912431T Expired - Lifetime ES2136088T3 (es) | 1991-06-17 | 1992-06-17 | Compuestos inmunogenos con efecto principalmente anti-citoquina, procedimiento de preparacion, composiciones farmaceuticas y kits que los contienen. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6093405A (es) |
EP (1) | EP0591281B1 (es) |
AT (1) | ATE185149T1 (es) |
AU (1) | AU2147992A (es) |
CA (1) | CA2111580C (es) |
DE (1) | DE69230068T2 (es) |
DK (1) | DK0591281T3 (es) |
ES (1) | ES2136088T3 (es) |
FR (1) | FR2677654B1 (es) |
GR (1) | GR3032037T3 (es) |
WO (1) | WO1992022577A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
IT1277926B1 (it) | 1995-09-01 | 1997-11-12 | Angeletti P Ist Richerche Bio | Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire |
WO1999048524A1 (en) * | 1998-03-03 | 1999-09-30 | University Of Southern California | Use of cytokines and mitogens to inhibit graft versus host disease |
FR2781158B1 (fr) | 1998-07-15 | 2002-12-13 | Vacs Internat | Nouvelles proteines modifiees immunogenes non immunosuppressives, leur procede de preparation et leurs applications |
EE200100552A (et) | 1999-04-23 | 2002-12-16 | Pharmexa A/S | Meetod kasvuteguri IL-5 aktiivsuse in vivo mahasurumiseks, IL-5 analoog, seda kodeeriv nukleiinhappefragment ning kasutamine immunogeense kompositsiooni valmistamiseks |
FR2792639B1 (fr) | 1999-04-26 | 2003-06-06 | Neovacs | Nouveaux immunogenes anti-vih (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida |
AU1075001A (en) * | 1999-10-05 | 2001-05-10 | Epimmune, Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
FR2802426B1 (fr) * | 1999-12-15 | 2004-04-02 | Neovacs | Utilisation de proteines immunogenes immunosuppressives et/ou angiogeniques rendues inactives, pour la production d'iga secretoires |
FR2812813B1 (fr) * | 2000-08-09 | 2004-11-26 | Neovacs | Utilisation d'immunogenes pour traiter ou prevenir au sein des tumeurs malignes les dereglements immunitaires induits par des facteurs extracellulaires |
AU2002303816B2 (en) * | 2001-05-21 | 2008-02-14 | The Research Foundation Of The State University Of New York | TSG101 as inhibitors of HIV production |
FR2828404B1 (fr) * | 2001-08-10 | 2005-07-15 | Neovacs | Superimmunogene composite a usage vaccinal bifonctionnel pour le traitement des maladies associees a un desordre tissulaire stromal |
JP2005529091A (ja) * | 2002-03-25 | 2005-09-29 | マーシア・ファーマ・リミテッド・ライアビリティ・カンパニー | エオタキシン伝達炎症状態の処置および予防方法および組成物 |
FR2838444B1 (fr) * | 2002-04-10 | 2016-01-01 | Neovacs | Nouveaux peptides et leur application en therapeutique |
FR2844514B1 (fr) * | 2002-09-16 | 2007-10-19 | Neovacs | Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation |
ES2347239T3 (es) | 2002-12-02 | 2010-10-27 | Amgen Fremont Inc. | Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos. |
AU2004224284A1 (en) * | 2003-03-24 | 2004-10-07 | Mercia Pharma, Inc | Methods and compositions for treating and preventing inflammatory conditions |
FR2859725B1 (fr) * | 2003-09-16 | 2006-03-10 | Neovacs | Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine |
US20110027220A1 (en) | 2005-09-28 | 2011-02-03 | Cytos Biotechnology Ag | Interleukin-1 Conjugates and Uses Thereof |
EP3187585A1 (en) | 2010-03-25 | 2017-07-05 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
US20130259892A1 (en) * | 2010-12-08 | 2013-10-03 | Geraldine Grouard-Vogel | Strongly inactivated and still highly immunogenic vaccine and process of manufacturing thereof |
EP2462950A1 (en) * | 2010-12-08 | 2012-06-13 | Neovacs | Strongly inactivated and still highly immunogenic vaccine, and process of manufacturing thereof |
DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4264587A (en) * | 1979-08-01 | 1981-04-28 | Pedersen Niels C | Vaccine for preventing persistent feline leukemia viremia in cats |
IL71555A (en) * | 1984-04-15 | 1992-06-21 | State Of Israel Israel Inst Fo | Bovine interferon |
NZ230372A (en) * | 1984-10-18 | 1994-02-25 | Pasteur Institut | Hiv antigen, assay and vaccine. |
JPH01500432A (ja) * | 1986-07-21 | 1989-02-16 | サウスウェスト・ファウンデーション・フォー・バイオメディカル・リサーチ | Aidsおよびarcのウィルス原因物質に対して免疫化するための組成物および方法 |
EP0273716B1 (en) * | 1986-12-30 | 1993-08-11 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Synthetic peptides which induce cellular immunity to the aids virus and aids viral proteins |
WO1988005783A1 (en) * | 1987-01-28 | 1988-08-11 | Ortho Pharmaceutical Corporation | Immunosuppressive peptides and methods of use |
US4833165A (en) * | 1987-10-07 | 1989-05-23 | Louderback Allan Lee | Method of inactivating HTLV-III virus in blood |
EP0323157A3 (en) * | 1987-12-24 | 1990-07-25 | The University Of Melbourne | Antiviral compounds and methods |
EP0330359A3 (en) * | 1988-02-25 | 1991-06-05 | Bio-Rad Laboratories, Inc. | Composition useful in the diagnosis and treating of hiv-1 infection |
FR2632310B1 (fr) * | 1988-06-06 | 1992-04-10 | Pasteur Institut | Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles |
GB8905400D0 (en) * | 1989-03-09 | 1989-04-19 | Jonker Margreet | Medicaments |
JPH03128393A (ja) * | 1989-05-17 | 1991-05-31 | Sangstat Medical Corp | ヒトリンパ栄養性ウィルスの処理及び診断 |
JPH05501201A (ja) * | 1989-10-16 | 1993-03-11 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 非感染性hiv―1粒子およびそれらの使用 |
FR2661834B1 (fr) * | 1990-05-09 | 1995-01-27 | Merieux Inst | Procede de fabrication d'immunogenes de retrovirus et de vaccins contre les infections retrovirales, notamment hiv, et immunogenes et vaccins obtenus. |
AU8007991A (en) * | 1990-06-29 | 1992-01-23 | Daniel Zagury | Methods of inducing immune response to aids virus |
-
1991
- 1991-06-17 FR FR9107399A patent/FR2677654B1/fr not_active Expired - Lifetime
-
1992
- 1992-06-17 EP EP92912431A patent/EP0591281B1/fr not_active Expired - Lifetime
- 1992-06-17 ES ES92912431T patent/ES2136088T3/es not_active Expired - Lifetime
- 1992-06-17 CA CA002111580A patent/CA2111580C/fr not_active Expired - Lifetime
- 1992-06-17 DE DE69230068T patent/DE69230068T2/de not_active Expired - Lifetime
- 1992-06-17 DK DK92912431T patent/DK0591281T3/da active
- 1992-06-17 US US08/167,867 patent/US6093405A/en not_active Expired - Lifetime
- 1992-06-17 AT AT92912431T patent/ATE185149T1/de active
- 1992-06-17 AU AU21479/92A patent/AU2147992A/en not_active Abandoned
- 1992-06-17 WO PCT/FR1992/000544 patent/WO1992022577A1/fr active IP Right Grant
-
1999
- 1999-05-25 US US09/317,993 patent/US6455045B1/en not_active Expired - Lifetime
- 1999-12-02 GR GR990403124T patent/GR3032037T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0591281A1 (fr) | 1994-04-13 |
GR3032037T3 (en) | 2000-03-31 |
FR2677654A1 (fr) | 1992-12-18 |
DE69230068D1 (de) | 1999-11-04 |
EP0591281B1 (fr) | 1999-09-29 |
US6455045B1 (en) | 2002-09-24 |
AU2147992A (en) | 1993-01-12 |
CA2111580C (fr) | 2003-12-09 |
WO1992022577A1 (fr) | 1992-12-23 |
ATE185149T1 (de) | 1999-10-15 |
US6093405A (en) | 2000-07-25 |
FR2677654B1 (fr) | 1995-11-17 |
DE69230068T2 (de) | 2000-03-09 |
DK0591281T3 (da) | 1999-12-20 |
CA2111580A1 (fr) | 1992-12-23 |
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