ES2136028B1 - Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos. - Google Patents

Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.

Info

Publication number
ES2136028B1
ES2136028B1 ES9702269A ES9702269A ES2136028B1 ES 2136028 B1 ES2136028 B1 ES 2136028B1 ES 9702269 A ES9702269 A ES 9702269A ES 9702269 A ES9702269 A ES 9702269A ES 2136028 B1 ES2136028 B1 ES 2136028B1
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Spain
Prior art keywords
procedure
sub
esters
preparation
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9702269A
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English (en)
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ES2136028A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to ES9702269A priority Critical patent/ES2136028B1/es
Priority to AU97507/98A priority patent/AU9750798A/en
Priority to PCT/ES1998/000293 priority patent/WO1999023064A1/es
Publication of ES2136028A1 publication Critical patent/ES2136028A1/es
Application granted granted Critical
Publication of ES2136028B1 publication Critical patent/ES2136028B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/26—Halogenosulfates, i.e. monoesters of halogenosulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esteres del ácido 2- (R) - fluorosulfoniloxi -4- fenilbutírico, procedimiento para su obtención y procedimiento para su utilización en la preparación de carboxialquildipéptidos; estos ésteres de fórmula I(R{sub,1 : bencilo o alquilo C{sub,1 -C{sub,6 ) se obtienen mediante reacción de ésteres del ácido 2- (R) -hidroxi -4- fenilbutírico con anhídrido fluorosulfónico en presencia de una base orgánica. Estos ésteres se utilizan en la preparación de carboxialquildipéptidos de fórmula II:(R{sub,1 : hidrógeno o alquilo C{sub,1 -C{sub,6 ; R{sub,2 : metilo o -(CH{sub,2 ){sub,4 -NH{sub,2 , R{sub,3 : hidrógeno).
ES9702269A 1997-11-03 1997-11-03 Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos. Expired - Fee Related ES2136028B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9702269A ES2136028B1 (es) 1997-11-03 1997-11-03 Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.
AU97507/98A AU9750798A (en) 1997-11-03 1998-10-29 2-(r)-fluorosulfonyloxy-4-phenylbutiric acid esters, production process and process for its utilization in the preparation of carboxyalkyldipeptides
PCT/ES1998/000293 WO1999023064A1 (es) 1997-11-03 1998-10-29 Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenilbutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9702269A ES2136028B1 (es) 1997-11-03 1997-11-03 Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.

Publications (2)

Publication Number Publication Date
ES2136028A1 ES2136028A1 (es) 1999-11-01
ES2136028B1 true ES2136028B1 (es) 2000-07-01

Family

ID=8301037

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9702269A Expired - Fee Related ES2136028B1 (es) 1997-11-03 1997-11-03 Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.

Country Status (3)

Country Link
AU (1) AU9750798A (es)
ES (1) ES2136028B1 (es)
WO (1) WO1999023064A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278476B2 (en) 2008-11-11 2012-10-02 Central Glass Company, Limited Process for producing α-substituted ester

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5359252B2 (ja) * 2008-10-22 2013-12-04 セントラル硝子株式会社 フルオロ硫酸エステル類の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
ES2019545A6 (es) * 1990-03-29 1991-06-16 Marga Investigacion Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278476B2 (en) 2008-11-11 2012-10-02 Central Glass Company, Limited Process for producing α-substituted ester

Also Published As

Publication number Publication date
AU9750798A (en) 1999-05-24
ES2136028A1 (es) 1999-11-01
WO1999023064A1 (es) 1999-05-14

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