ES2135570T3 - Composicion para la administracion oral de peptidos. - Google Patents

Composicion para la administracion oral de peptidos.

Info

Publication number
ES2135570T3
ES2135570T3 ES94911346T ES94911346T ES2135570T3 ES 2135570 T3 ES2135570 T3 ES 2135570T3 ES 94911346 T ES94911346 T ES 94911346T ES 94911346 T ES94911346 T ES 94911346T ES 2135570 T3 ES2135570 T3 ES 2135570T3
Authority
ES
Spain
Prior art keywords
pct
oral administration
spheres
date sep
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94911346T
Other languages
English (en)
Inventor
Anne Fjellestad-Paulsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FJELLESTAD PAULSEN ANNE
Original Assignee
FJELLESTAD PAULSEN ANNE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FJELLESTAD PAULSEN ANNE filed Critical FJELLESTAD PAULSEN ANNE
Application granted granted Critical
Publication of ES2135570T3 publication Critical patent/ES2135570T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTA UNA COMPOSICION FARMACEUTICA SOLIDA PARA LA ADMINISTRACION ORAL DE PEPTIDOS DE TAMAÑO PEQUEÑO Y MEDIANO, PARTICULARMENTE VASOPRESINA, OXITOCINA Y SUS ANALOGOS, QUE COMPRENDE DICHO PEPTIDOS, UN INHIBIDOR DE LA PROTEASA, UN RECUBRIMIENTO ENTERICO Y UN PORTADOR FARMACOLOGICAMENTE ACEPTABLE QUE CONTENGA UN AGENTE NEUTRALIZANTE PARA NEUTRALIZAR EL PH ENTRE 3 Y 6, PREFERIBLEMENTE ALREDEDOR DE 5. TAMBIEN SE PRESENTA UN METODO PARA MANUFACTURAR DOSIS SIMPLE DE DICHO PEPTIDO QUE COMPRENDE LA MEZCLA DE LOS INGREDIENTES, LA FORMACION DE LA MEZCLA RESULTANTE EN ESFERAS MENORES DE 2 MM, EL RECUBRIMIENTO DE LAS ESFERAS CON UN RECUBRIMIENTO ENTERICO QUE SEA FACILMENTE SOLUBLE EN LOS JUGOS GASTRICOS DE UN PH DE 5.0 O MAYOR PERO NO A UN PH SUBSTANCIALMENTE INFERIOR, Y EL RELLENO DE LAS ESFERAS RECUBIERTAS EN CAPSULAS O LA INCORPORACION DE LAS MISMAS EN TABLETAS, DEGRADABLES EN EL ESTOMAGO. TAMBIEN SE SUMINISTRA UN METODO PARA LA ADMINISTRACION ORAL A UN PACIENTE DE DICHA DOSIS SIMPLE.
ES94911346T 1993-03-19 1994-03-18 Composicion para la administracion oral de peptidos. Expired - Lifetime ES2135570T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9300937A SE9300937L (sv) 1993-03-19 1993-03-19 Komposition för oral administrering av peptider

Publications (1)

Publication Number Publication Date
ES2135570T3 true ES2135570T3 (es) 1999-11-01

Family

ID=20389308

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94911346T Expired - Lifetime ES2135570T3 (es) 1993-03-19 1994-03-18 Composicion para la administracion oral de peptidos.

Country Status (10)

Country Link
US (1) US5780434A (es)
EP (1) EP0689452B1 (es)
AT (1) ATE181508T1 (es)
AU (1) AU6388994A (es)
DE (1) DE69419246T2 (es)
DK (1) DK0689452T3 (es)
ES (1) ES2135570T3 (es)
GR (1) GR3031312T3 (es)
SE (1) SE9300937L (es)
WO (1) WO1994021286A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
SE9400918L (sv) * 1994-03-18 1995-09-19 Anne Fjellstad Paulsen Stabiliserad komposition för oral administrering av peptider
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
JP4344136B2 (ja) 2000-11-10 2009-10-14 エフ・ホフマン−ラ・ロシュ・リミテッド アポリポタンパク質類似体
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1530967B1 (en) * 2003-11-13 2006-05-03 Ferring B.V. Blister pack and solid dosage form comprising desmopressin
CN101107013A (zh) 2004-11-22 2008-01-16 阿纳迪斯有限公司 生物活性组合物
US20090317377A1 (en) * 2005-08-26 2009-12-24 Yeomans David C Therapy procedure for drug delivery for trigeminal pain
SE0600482L (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
CA2988753A1 (en) 2007-08-06 2009-02-12 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
ES2319054B1 (es) 2007-08-06 2010-02-12 Gp Pharm S.A. Composicion farmaceutica oral de desmopresina.
LT2712622T (lt) * 2008-05-21 2016-09-26 Ferring B.V. Burnoje disperguojamas desmopresinas, skirtas nikturijos netrikdomo miego pirminio periodo pailginimui
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
PL4104848T3 (pl) 2009-06-18 2024-03-25 Acerus Pharmaceuticals USA, LLC Bezpieczne podawanie desmopresyny
SI3242676T1 (sl) 2015-01-07 2024-02-29 Tonix Pharma Limited Formulacije oksitocina, ki vsebujejo magnezij in načini uporabe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139504A (en) * 1977-06-16 1979-02-13 Coy David Howard Novel nonapeptides, intermediates therefor, and compositions and methods employing said nonapeptides
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
JPS608225A (ja) * 1983-06-29 1985-01-17 Kowa Co 腸管吸収医薬組成物
SE8306367L (sv) * 1983-11-18 1985-05-19 Ferring Ab Antidiuretiskt verkande farmaceutiskt preparat
US4849227A (en) * 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
AU637316B2 (en) * 1988-01-28 1993-05-27 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform
JP3009911B2 (ja) * 1989-06-28 2000-02-14 エーザイ株式会社 ペプチド又は蛋白の内服用新規製剤
JPH04364131A (ja) * 1991-04-03 1992-12-16 Sanwa Kagaku Kenkyusho Co Ltd 易吸収性モチリン製剤
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments

Also Published As

Publication number Publication date
DE69419246T2 (de) 2000-01-20
DE69419246D1 (de) 1999-07-29
EP0689452A1 (en) 1996-01-03
WO1994021286A1 (en) 1994-09-29
SE9300937L (sv) 1994-09-20
SE9300937D0 (sv) 1993-03-19
AU6388994A (en) 1994-10-11
ATE181508T1 (de) 1999-07-15
EP0689452B1 (en) 1999-06-23
GR3031312T3 (en) 1999-12-31
DK0689452T3 (da) 1999-12-13
US5780434A (en) 1998-07-14

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