IL41524A - Pharmaceutical compositions containing a derivative of proline - Google Patents
Pharmaceutical compositions containing a derivative of prolineInfo
- Publication number
- IL41524A IL41524A IL41524A IL4152473A IL41524A IL 41524 A IL41524 A IL 41524A IL 41524 A IL41524 A IL 41524A IL 4152473 A IL4152473 A IL 4152473A IL 41524 A IL41524 A IL 41524A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- prolyl
- succinimide
- oxy
- carboxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1415055 Compositions for treating ulcers BOEHRINGER INGELHEIM GmbH 13 Feb 1973 [14 Feb 1972] 7071/73 Heading A5B Pharmaceutical compositions comprise N- [(1-carboxy-L-prolyl)- oxy] - succinimide tbutyl ester of the formula: as active ingredient, in association with a pharmaceutical carrier or diluent. Other active ingredients such as hypnotics, tranquilizers, spasmolytics or anaesthetics e.g. 7-chloro-1, 3- dihydro-3-hydroxy-5-phenyl-2H-1, 4-benzodiazepin-2-one may also be present. The compositions may be in a form suitable for oral, parenteral or rectal administration.
[GB1415055A]
Claims (15)
1. Pharmaceutical compositions, (as herein defined) comprising N- [ ( 1-carboxy-L-prolyl )-oxy] -succinimide t-butyl ester of the formula : 0 as active ingredient, in association with a pharmaceutical carrier or excipient.
2. Pharmaceutical compositions comprising N-[(l-carboxy-L-prolyl )-oxy]-succinimide t-butyl ester of the formula as active ingredient in association with written or printed instructions for the use of the said composition for the treatment of ulcers of the digestive tract and/or for the inhibition of fluid secretions of the digestive tract.
3. Compositions as claimed in claim 2 in a container with the written or printed instructions physically attached thereto.
4. Compositions as claimed in claim 2 in a contain-, er thereof with separate directions . for the use thereof" provided together with the container.
5. Compositions as claimed in any of the preceding claims in a form suitable for oral, parenteral or rectal administration.
6. Composition's as claimed in claim 5 in the form of tablets, capsules, coated tablets, granules, pills, syrups, emulsions, suspensions, powders, dispersible powders, suppositories or injection solutions.
7. Compositions as claimed in any of the preceding claims in the form of dosage units.
8. Compositions as claimed in claim 7, for oral administration, wherein each dosage unit contains from 13.3 to 400 mg of N- [ ( l-carboxy-L-prolyl )-oxy]-succinimide J;-butyl ester.
9. Compositions as claimed in claim 8 wherein each dosage unit contains from 16.6 to 200 mg of N-[(l-carboxy-L-prolyl )-oxy]-succinimide t-butyl ester.
10. Compositions as claimed in claim 7, for parenteral administration, wherein each dosage unit contains from 5 to 100 mg of N- [ ( l-carboxy-L-prolyl )-oxy]-succinimide t-butyl ester.
11. Compositions as claimed in any of the preceding claims which contain a further physiologically active ingredient.
12. Compositions as claimed in claim 11 wherein the further physiologically active ingredient comprises an anaesthetic, hypnotic, tranquilizer or spasmolytic.
13. Compositions as claimed in claim 12 wherein the further physiologically active ingredient comprises 7-chloro-l , 3-dihydro-3-hydroxy-5-phenyl-2H-l ,4-benzo-diazepin-2-one. 41524/2
14. · Compositions as claimed in claim 1 substantially as herein described.
15. Pharmaceutical compositions substantially as herein described in any of the Examples. For the A; iicants . ΕΕΙΝΣΓ ,D NCOHH AND PASTISERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2206867A DE2206867A1 (en) | 1972-02-14 | 1972-02-14 | AGENT FOR GIOMATIC JUICE INHIBITION AND ULCUS TREATMENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41524A0 IL41524A0 (en) | 1973-04-30 |
| IL41524A true IL41524A (en) | 1976-03-31 |
Family
ID=5835916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41524A IL41524A (en) | 1972-02-14 | 1973-02-13 | Pharmaceutical compositions containing a derivative of proline |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU474663B2 (en) |
| BE (1) | BE795383A (en) |
| DE (1) | DE2206867A1 (en) |
| FR (1) | FR2183669B1 (en) |
| GB (1) | GB1415055A (en) |
| IL (1) | IL41524A (en) |
| NL (1) | NL7301995A (en) |
| ZA (1) | ZA731001B (en) |
-
1972
- 1972-02-14 DE DE2206867A patent/DE2206867A1/en active Pending
-
1973
- 1973-02-13 BE BE795383D patent/BE795383A/en unknown
- 1973-02-13 NL NL7301995A patent/NL7301995A/xx unknown
- 1973-02-13 GB GB707173A patent/GB1415055A/en not_active Expired
- 1973-02-13 ZA ZA731001A patent/ZA731001B/en unknown
- 1973-02-13 AU AU52115/73A patent/AU474663B2/en not_active Expired
- 1973-02-13 IL IL41524A patent/IL41524A/en unknown
- 1973-02-14 FR FR7305136A patent/FR2183669B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA731001B (en) | 1974-11-27 |
| IL41524A0 (en) | 1973-04-30 |
| FR2183669A1 (en) | 1973-12-21 |
| DE2206867A1 (en) | 1973-08-23 |
| FR2183669B1 (en) | 1976-07-02 |
| NL7301995A (en) | 1973-08-16 |
| AU5211573A (en) | 1974-08-15 |
| GB1415055A (en) | 1975-11-26 |
| AU474663B2 (en) | 1976-07-29 |
| BE795383A (en) | 1973-08-13 |
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