ES2126577T3 - Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo. - Google Patents

Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo.

Info

Publication number
ES2126577T3
ES2126577T3 ES91919785T ES91919785T ES2126577T3 ES 2126577 T3 ES2126577 T3 ES 2126577T3 ES 91919785 T ES91919785 T ES 91919785T ES 91919785 T ES91919785 T ES 91919785T ES 2126577 T3 ES2126577 T3 ES 2126577T3
Authority
ES
Spain
Prior art keywords
tetrones
analogs
aminoespire
alkylidenic
pirrolidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919785T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2126577T3 publication Critical patent/ES2126577T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ANALOGOS DE ALQUILIDENO DE AMINOSPIRO [ISOQUINOLINA-4(1H),3''-PIROLIDINA]-1,2'',3,5''(2H)TETRONAS (I), A PROCESOS PARA SU PREPARACION, A METODOS DE EMPLEO DE LOS COMPUESTOS Y A COMPOSICIONES FARMACEUTICAS DE LOS MISMOS. LOS COMPUESTOS POSEEN PROPIEDADES FARMACEUTICAS FAVORABLES EN LA PREVENCION Y EL TRATAMIENTO DE COMPLICACIONES SECUNDARIAS DE LA DIABETES MELITUS.
ES91919785T 1990-10-12 1991-10-10 Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo. Expired - Lifetime ES2126577T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/596,889 US5068332A (en) 1990-10-12 1990-10-12 Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
ES2126577T3 true ES2126577T3 (es) 1999-04-01

Family

ID=24389149

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919785T Expired - Lifetime ES2126577T3 (es) 1990-10-12 1991-10-10 Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo.

Country Status (16)

Country Link
US (1) US5068332A (es)
EP (1) EP0555327B1 (es)
JP (1) JP3115597B2 (es)
KR (1) KR100212110B1 (es)
AT (1) ATE175673T1 (es)
AU (1) AU645866B2 (es)
CA (1) CA2093793C (es)
DE (1) DE69130771T2 (es)
DK (1) DK0555327T3 (es)
ES (1) ES2126577T3 (es)
GR (1) GR3029883T3 (es)
HK (1) HK1011356A1 (es)
LV (1) LV12444B (es)
PT (1) PT99185B (es)
SG (1) SG47811A1 (es)
WO (1) WO1992006974A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
EP0618917B1 (en) * 1991-11-25 1997-03-26 American Home Products Corporation 1'-amino-2- (benzothiazolyl)methyl]spiro isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5189167A (en) * 1991-11-25 1993-02-23 American Home Products Corporation Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
ES2185693T3 (es) * 1994-01-19 2003-05-01 Sankyo Co Derivado de pirrolopiridacina.
EP2139330B1 (en) 2007-03-23 2014-09-24 The Board of Regents of The University of Texas System Methods involving aldose reductase inhibitors
JP4708469B2 (ja) 2008-02-29 2011-06-22 Ｔｄｋ株式会社 バルントランス

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5045544A (en) * 1990-05-21 1991-09-03 American Home Products Corporation N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
AU8922891A (en) 1992-05-20
PT99185A (pt) 1992-09-30
SG47811A1 (en) 1998-04-17
ATE175673T1 (de) 1999-01-15
KR100212110B1 (ko) 1999-08-02
LV12444B (en) 2000-06-20
LV12444A (en) 2000-03-20
EP0555327A1 (en) 1993-08-18
US5068332A (en) 1991-11-26
PT99185B (pt) 1999-04-30
JPH06502169A (ja) 1994-03-10
KR930702347A (ko) 1993-09-08
GR3029883T3 (en) 1999-07-30
CA2093793A1 (en) 1992-04-13
EP0555327B1 (en) 1999-01-13
JP3115597B2 (ja) 2000-12-11
DK0555327T3 (da) 1999-08-30
AU645866B2 (en) 1994-01-27
CA2093793C (en) 2001-08-21
WO1992006974A1 (en) 1992-04-30
DE69130771D1 (de) 1999-02-25
HK1011356A1 (en) 1999-07-09
DE69130771T2 (de) 1999-05-27

Similar Documents

Publication Publication Date Title
DE69034162D1 (de) N-substituierte Cycloalkyl- und Polycycloalkyl-alpha-substituierte Trp-Phe- und Phenethylaminderivate
PL306084A1 (en) Novel compound and method of obtaining them as well as pharmaceutic agent containing such compounds
WO2003048164A3 (en) Adenosine a2a receptor antagonists
DK0546108T3 (da) Pro-drugs for CCK-antagonister
ES2126577T3 (es) Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo.
CN105732659B (zh) 硝基咪唑类化合物及其制备方法和在制药中的用途
DE69017265D1 (de) Pyrrolidonderivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel.
CA2093794A1 (en) 1'-aminospiro¬isoquinoline-4(1h),3-pyrrolidine|-1,2',3,5'-(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors
EP0276805A3 (en) Substituted 3-phenyl-7h-thiazoloû3,2-b¨û1,2,4¨triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds
TH5989A (th) นิวคลีโอไซด์ที่ใช้รักษาโรค
IL96683A0 (en) Imidazolyl propyl guanidine derivative,a process for its preparation and a pharmaceutical composition containing this compound
DE69218626D1 (de) 1'-amino-2[(benzothiazolyl)methyl] spiro [isochinolin-4(1h), 3'-pyrrolidine]-1,2',3,5'-tetrone und analoge davon verwendbar als aldosereduktase luhibitoren

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 555327

Country of ref document: ES