ES2125817A1 - Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas. - Google Patents
Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas.Info
- Publication number
- ES2125817A1 ES2125817A1 ES09700099A ES9700099A ES2125817A1 ES 2125817 A1 ES2125817 A1 ES 2125817A1 ES 09700099 A ES09700099 A ES 09700099A ES 9700099 A ES9700099 A ES 9700099A ES 2125817 A1 ES2125817 A1 ES 2125817A1
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- liquid crystals
- interaction
- production
- polymer liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K19/00—Liquid crystal materials
- C09K19/04—Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
- C09K19/38—Polymers
- C09K19/3804—Polymers with mesogenic groups in the main chain
- C09K19/3809—Polyesters; Polyester derivatives, e.g. polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Liquid Crystal Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Obtención de nuevos cristales líquidos polímeros capaces de interaccionar con liposomas. Procedimiento que comprende las siguientes etapas: a) Preparación de los liposomas (bicapas), por extrusión a partir de lípidos, tal como el dimlristoilfosfatidilcolina; b) Preparación de los polímeros (-) PTOBEE (C26 H20 O8)n y PTOBDME (C34 H36 O8)n , ambos cristales líquidos de naturaleza colestérica; c) Adición de los polímeros a la suspensión de los liposomas. Estos sistemas tienen aplicaciones biomédicas y farmacológicas como "stealth liposomes" o "liposomas fantasmas", para el encapsulamiento de fármacos, con el consiguiente aumento de su vida media en el torrente sanguíneo.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009700099A ES2125817B1 (es) | 1997-01-20 | 1997-01-20 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas. |
EP98900282A EP0966959A1 (en) | 1997-01-20 | 1998-01-16 | Production of new polymer liquid crystals capable of having an interaction with liposomes |
CA002278567A CA2278567A1 (en) | 1997-01-20 | 1998-01-16 | Production of new polymer liquid crystals capable of having an interaction with liposomes |
AU54862/98A AU738141B2 (en) | 1997-01-20 | 1998-01-16 | Production of new polymer liquid crystals capable of having an interaction with liposomes |
US09/355,090 US6277403B1 (en) | 1997-01-20 | 1998-01-16 | Production of new polymer liquid crystals capable of having an interaction with liposomes |
JP53379598A JP2001514616A (ja) | 1997-01-20 | 1998-01-16 | リポソームとの相互作用を有することができる新規ポリマー液晶の製造 |
PCT/ES1998/000005 WO1998031347A1 (es) | 1997-01-20 | 1998-01-16 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas |
ES009901362A ES2165275B1 (es) | 1997-01-20 | 1999-06-18 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009700099A ES2125817B1 (es) | 1997-01-20 | 1997-01-20 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2125817A1 true ES2125817A1 (es) | 1999-03-01 |
ES2125817B1 ES2125817B1 (es) | 2000-01-01 |
Family
ID=8297921
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009700099A Expired - Fee Related ES2125817B1 (es) | 1997-01-20 | 1997-01-20 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas. |
ES009901362A Expired - Fee Related ES2165275B1 (es) | 1997-01-20 | 1999-06-18 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901362A Expired - Fee Related ES2165275B1 (es) | 1997-01-20 | 1999-06-18 | Obtencion de nuevos cristales liquidos polimeros capaces de interaccionar con liposomas |
Country Status (7)
Country | Link |
---|---|
US (1) | US6277403B1 (es) |
EP (1) | EP0966959A1 (es) |
JP (1) | JP2001514616A (es) |
AU (1) | AU738141B2 (es) |
CA (1) | CA2278567A1 (es) |
ES (2) | ES2125817B1 (es) |
WO (1) | WO1998031347A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7230088B2 (en) | 2001-07-03 | 2007-06-12 | Mallinckrodt, Inc. | Compounds for dual photodiagnosis and therapy |
US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
US6669926B1 (en) * | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
WO2007106436A2 (en) * | 2006-03-10 | 2007-09-20 | Mallinckrodt Inc. | Photoactive compounds and compositions and uses thereof |
WO2007149479A1 (en) | 2006-06-22 | 2007-12-27 | Mallinckrodt Inc. | Pyrazine derivatives and uses thereof in renal monitoring |
US8664392B2 (en) | 2004-12-23 | 2014-03-04 | Medibeacon, LLC | Pyrazine derivatives for bioconjugation |
JP2009528373A (ja) * | 2006-03-02 | 2009-08-06 | マリンクロッド・インコーポレイテッド | チアジアゾール化合物および光線療法のためのその使用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4999348A (en) * | 1987-12-11 | 1991-03-12 | Estee Lauder Inc. | Liquid crystal containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions |
WO1993019735A1 (fr) * | 1992-04-03 | 1993-10-14 | Centre National De La Recherche Scientifique (Cnrs) | Procede de preparation de micro-capsules ou de liposomes de tailles controlees |
WO1994020073A1 (en) * | 1993-03-03 | 1994-09-15 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0486437B1 (en) | 1990-11-13 | 1997-07-09 | ISTITUTO SIEROVACCINOGENO ITALIANO I.S.I. S.p.A. | Functional polyesters from glycidyl derivatives and cyclic anhydrides or carbon dioxide |
IT1242214B (it) | 1990-11-13 | 1994-03-03 | Emo Chiellini | Derivati polifunzionali delle ciclodestrine |
IT1244511B (it) | 1991-04-15 | 1994-07-15 | Isi Ist Sierovaccinogeno Ital | Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione. |
JP3308010B2 (ja) * | 1992-12-15 | 2002-07-29 | ポーラ化成工業株式会社 | 被膜安定化リポソーム及びその製造方法 |
-
1997
- 1997-01-20 ES ES009700099A patent/ES2125817B1/es not_active Expired - Fee Related
-
1998
- 1998-01-16 WO PCT/ES1998/000005 patent/WO1998031347A1/es not_active Application Discontinuation
- 1998-01-16 JP JP53379598A patent/JP2001514616A/ja active Pending
- 1998-01-16 US US09/355,090 patent/US6277403B1/en not_active Expired - Fee Related
- 1998-01-16 EP EP98900282A patent/EP0966959A1/en not_active Withdrawn
- 1998-01-16 CA CA002278567A patent/CA2278567A1/en not_active Abandoned
- 1998-01-16 AU AU54862/98A patent/AU738141B2/en not_active Ceased
-
1999
- 1999-06-18 ES ES009901362A patent/ES2165275B1/es not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4999348A (en) * | 1987-12-11 | 1991-03-12 | Estee Lauder Inc. | Liquid crystal containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions |
WO1993019735A1 (fr) * | 1992-04-03 | 1993-10-14 | Centre National De La Recherche Scientifique (Cnrs) | Procede de preparation de micro-capsules ou de liposomes de tailles controlees |
WO1994020073A1 (en) * | 1993-03-03 | 1994-09-15 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
Also Published As
Publication number | Publication date |
---|---|
AU738141B2 (en) | 2001-09-06 |
ES2165275A1 (es) | 2002-03-01 |
JP2001514616A (ja) | 2001-09-11 |
ES2165275B1 (es) | 2003-10-16 |
US6277403B1 (en) | 2001-08-21 |
CA2278567A1 (en) | 1998-07-23 |
WO1998031347A1 (es) | 1998-07-23 |
ES2125817B1 (es) | 2000-01-01 |
AU5486298A (en) | 1998-08-07 |
EP0966959A1 (en) | 1999-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990301 Kind code of ref document: A1 Effective date: 19990301 |
|
FA2A | Application withdrawn |
Effective date: 19990630 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180807 |