ES2124279T3 - Dihidrato cristalino de una sal diclorhidrato de cefalosporina y composiciones inyectables del mismo. - Google Patents

Dihidrato cristalino de una sal diclorhidrato de cefalosporina y composiciones inyectables del mismo.

Info

Publication number
ES2124279T3
ES2124279T3 ES93114343T ES93114343T ES2124279T3 ES 2124279 T3 ES2124279 T3 ES 2124279T3 ES 93114343 T ES93114343 T ES 93114343T ES 93114343 T ES93114343 T ES 93114343T ES 2124279 T3 ES2124279 T3 ES 2124279T3
Authority
ES
Spain
Prior art keywords
cefepime
cephalosporin
dihydrochloride dihydrate
salt
injectable compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93114343T
Other languages
English (en)
Inventor
Elizabeth Ann Garofalo
Gary M F Lim
Murray Arthur Kaplan
Munir N Nassar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2124279T3 publication Critical patent/ES2124279T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

SE DESCRIBE UNA NUEVA SAL DE DIHIDRATO HIDROCLORURO CRISTALINO DEL ANTIBIOTICO CEFALOSPORINA CEFEPIMA. EN PARTICULAR SE OFRECE UN DIHIDRATO DE DIHIDROCLORURO CRISTALINO DE TEMPERATURA Y HUMEDAD ESTABLE EN FORMA DE CEFEPIMA CON UNA ESTABILIDAD INTENSIFICADA Y UNA ESTRUCTURA DE DIFRACCION EN POLVO DE RAYOS-X ESPECIFICA CON L(+) ANGINA. LA ADMINISTRACION FISICA DE LA NUEVA SAL CON UN DIHIDRATO DE DIHIDROCLORURO ORGANICO O NORGANICO NO TOXICO FARMACEUTICAMENTE ACEPTABLE.
ES93114343T 1992-09-08 1993-09-07 Dihidrato cristalino de una sal diclorhidrato de cefalosporina y composiciones inyectables del mismo. Expired - Lifetime ES2124279T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94159192A 1992-09-08 1992-09-08
US94158492A 1992-09-08 1992-09-08

Publications (1)

Publication Number Publication Date
ES2124279T3 true ES2124279T3 (es) 1999-02-01

Family

ID=27130161

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93114343T Expired - Lifetime ES2124279T3 (es) 1992-09-08 1993-09-07 Dihidrato cristalino de una sal diclorhidrato de cefalosporina y composiciones inyectables del mismo.

Country Status (9)

Country Link
EP (1) EP0587121B1 (es)
JP (1) JP3868008B2 (es)
AT (1) ATE173265T1 (es)
AU (1) AU671658B2 (es)
CA (1) CA2101571A1 (es)
DE (1) DE69322030T2 (es)
DK (1) DK0587121T3 (es)
ES (1) ES2124279T3 (es)
GR (1) GR3029306T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498777A (en) * 1994-07-20 1996-03-12 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use
JP2914324B2 (ja) 1995-10-23 1999-06-28 味の素株式会社 ピペリジン誘導体の結晶並びにその製造中間体及び製造方法
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
KR100900208B1 (ko) * 2004-12-17 2009-06-02 비너스 레머디스 리미티드 감염의 치료에 대해 토탈 솔루션을 제공하는 항생제 배합물
ES2353482T3 (es) * 2006-02-10 2011-03-02 Amgen, Inc Formas hidrato de amg706.
CN102351885B (zh) * 2011-08-19 2012-08-22 深圳立健药业有限公司 用于制备头孢呋辛-l-精氨酸水合物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145686B (it) * 1979-05-25 1986-11-05 Glaxo Group Ltd Intermedi per la preparazione di antibiotici cefalosporinici e procedimento per prepararli
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
EP0175544A3 (en) * 1984-09-17 1987-06-03 Eli Lilly And Company An improved process for cephalosporin intermediates
US4994451A (en) * 1988-01-19 1991-02-19 Bristol-Myers Company Cephalosporin salts and injectable compositions
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate

Also Published As

Publication number Publication date
EP0587121A1 (en) 1994-03-16
ATE173265T1 (de) 1998-11-15
JP3868008B2 (ja) 2007-01-17
DE69322030T2 (de) 1999-07-15
DK0587121T3 (da) 1999-07-26
AU671658B2 (en) 1996-09-05
JPH06192271A (ja) 1994-07-12
GR3029306T3 (en) 1999-05-28
DE69322030D1 (de) 1998-12-17
EP0587121B1 (en) 1998-11-11
AU4616493A (en) 1994-03-17
CA2101571A1 (en) 1994-03-09

Similar Documents

Publication Publication Date Title
GB2239016B (en) N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carbo xamide & asparaginyl derivatives thereof
ES2160949T3 (es) Derivados de fenilen-sulfonamida sustituidos en meta.
AR005597A1 (es) Derivados de benzoxazina , composiciones farmaceuticas para el tratamiento de infecciones bacterianas, y metodo para la preparacion de dichos derivados.
NO975901L (no) Vinyl-pyrrolidinon cefalosporiner med basiske substituenter
IT8348006A0 (it) Loro produzione derivati cefalosporinici e composizioni antibatteriche che li contengono, nonche' procedimento per la
ATE74756T1 (de) Zwitterion-bicyclische verbindungen, deren salze, solvate, hydrate und ester.
IT8947539A0 (it) Sali cefalosporinici e relative composizioni iniettabili, nonche' procedimento di preparazione
PT992509E (pt) Novos derivados macrolidos
IL84359A0 (en) Substituted cephalosporin sulfones,their preparation and pharmaceutical compositions containing them
NZ217650A (en) Quinoline derivatives and pharmaceutical compositions
ES2124279T3 (es) Dihidrato cristalino de una sal diclorhidrato de cefalosporina y composiciones inyectables del mismo.
ES2083708T3 (es) Nuevas piperazinilalcoil-3 dihidro-2,3,4h-benzoxazina-1,3 onas-4 sustituidas, su preparacion y su aplicacion en terapeutica.
ATE261425T1 (de) Erythromycin-derivate mit antibiotischer wirkung
ES2102772T3 (es) Compuesto citotoxico y antiviral.
DK0628042T3 (da) Serotoninerge ergolinderivater
ES8205810A1 (es) Un procedimiento para preparar nuevos compuestos de cefem
ES2100177T3 (es) Compuestos de cefalosporina y su produccion.
SE8306225D0 (sv) 2-piperazinyl-quinazoline derivatives, their production and pharmaceutical compositions containing them
FI862566A (fi) Foerfarande foer framstaellning av nya penemderivat.
ES449688A1 (es) Procedimiento para la preparacion de un acido 7-(alfa-amino-w-(3, 4-metilenodioxifenil) acilamido) cefalosporanico.
ES449991A1 (es) Procedimiento para la preparacion de derivados de acido 7 (alfaamino-omega-(2,3-metilenodioxifenil y acilamido) cefa- losporanico.
PT952157E (pt) Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina
IL99782A0 (en) Ergoline derivatives,their production and pharmaceutical compositions containing them
YU236390A (sh) Derivati 10,11,12,13-tetrahidro-desmikozina i postupak za njihovo dobijanje
SE8900725L (sv) Indolfoereningar och framstaellning daerav

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 587121

Country of ref document: ES