ES2121764T3 - Un metodo para aumentar la produccion de antibioticos beta-lactamicos y para aislar grandes cantidades de acv-sinteasa. - Google Patents

Un metodo para aumentar la produccion de antibioticos beta-lactamicos y para aislar grandes cantidades de acv-sinteasa.

Info

Publication number
ES2121764T3
ES2121764T3 ES91200423T ES91200423T ES2121764T3 ES 2121764 T3 ES2121764 T3 ES 2121764T3 ES 91200423 T ES91200423 T ES 91200423T ES 91200423 T ES91200423 T ES 91200423T ES 2121764 T3 ES2121764 T3 ES 2121764T3
Authority
ES
Spain
Prior art keywords
production
beta
sintease
acv
increase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91200423T
Other languages
English (en)
Inventor
Annemarie Eveline Veenstra
Juan Francisco Martin
Bruno Diez Garcia
Santiago Guttierez
Jose Luis Barredo
Prieto Eduardo Montenegro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2121764T3 publication Critical patent/ES2121764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE FACILITAN NUEVOS METODOS Y COMPOSICIONES PARA LA PRODUCCION MEJORADA DE ANTIBIOTICOS DE (BETA)-LACTAMA FERMENTABLES O CONOCIDOS Y NUEVOS. EL PROCESO ESTA EJEMPLIFICADO POR LA PRODUCCION DE PENICILINA. ADEMAS, LOS GENES DE P.CHRYSOGENUM Y A.CHRYSOGENUM DELTA-(L-(ALFA)-AMINOADIPILO)-L -CISTEINILO-D-VALINA SINTETASA SE HAN AISLADO Y SECUENCIADO. TAMBIEN SE FACILITAN METODOS PARA LA PRODUCCION DE DELTA-(L-(ALFA)-AMINOADIPILO)-L -CISTEINILO-D-VALINA SINTETASA UTILIZANDO TECNICAS DE ADN RECOMBINADO.
ES91200423T 1990-02-28 1991-02-27 Un metodo para aumentar la produccion de antibioticos beta-lactamicos y para aislar grandes cantidades de acv-sinteasa. Expired - Lifetime ES2121764T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP90200475 1990-02-28
EP90200488 1990-02-28
EP90201768 1990-07-02
EP90202628 1990-10-03

Publications (1)

Publication Number Publication Date
ES2121764T3 true ES2121764T3 (es) 1998-12-16

Family

ID=27441987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91200423T Expired - Lifetime ES2121764T3 (es) 1990-02-28 1991-02-27 Un metodo para aumentar la produccion de antibioticos beta-lactamicos y para aislar grandes cantidades de acv-sinteasa.

Country Status (7)

Country Link
EP (2) EP0445868B1 (es)
JP (1) JPH06105682A (es)
AT (1) ATE169059T1 (es)
DE (1) DE69129869T2 (es)
ES (1) ES2121764T3 (es)
IE (1) IE910660A1 (es)
PT (1) PT96912B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1171590A1 (en) * 1999-03-26 2002-01-16 Human Genome Sciences, Inc. 50 human secreted proteins
EP2589663A1 (en) * 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid
WO2017178624A1 (en) * 2016-04-14 2017-10-19 Dsm Sinochem Pharmaceuticals Netherlands B.V. Mbth-like proteins in eukaryotic nrps-catalyzed processes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0280051A1 (en) * 1987-02-17 1988-08-31 Queen's University At Kingston ACV synthetase
GB8728811D0 (en) * 1987-12-09 1988-01-27 Beecham Group Plc Novel substance
FI104264B (fi) * 1988-08-11 1999-12-15 Dsm Ip Assets Bv Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä

Also Published As

Publication number Publication date
IE910660A1 (en) 1991-08-28
EP0444758A1 (en) 1991-09-04
PT96912B (pt) 1998-07-31
PT96912A (pt) 1991-10-31
ATE169059T1 (de) 1998-08-15
EP0445868B1 (en) 1998-07-29
DE69129869T2 (de) 1999-01-14
EP0445868A1 (en) 1991-09-11
JPH06105682A (ja) 1994-04-19
DE69129869D1 (de) 1998-09-03

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