ES2120098T3 - Procedimiento y productos intermedios para la preparacion de 5-oxaespiro(2.4)heptan-6-ona. - Google Patents

Procedimiento y productos intermedios para la preparacion de 5-oxaespiro(2.4)heptan-6-ona.

Info

Publication number
ES2120098T3
ES2120098T3 ES95105830T ES95105830T ES2120098T3 ES 2120098 T3 ES2120098 T3 ES 2120098T3 ES 95105830 T ES95105830 T ES 95105830T ES 95105830 T ES95105830 T ES 95105830T ES 2120098 T3 ES2120098 T3 ES 2120098T3
Authority
ES
Spain
Prior art keywords
heptan
oxaespiro
ona
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95105830T
Other languages
English (en)
Inventor
Paul Dr Hanselmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2120098T3 publication Critical patent/ES2120098T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/12—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)

Abstract

5 - OXASPIRO[2,4] HEPTANO - 6 - ONA SE OBTIENE A PARTIR DE [3 - (HIDROXIMETIL)OXETANO - 3 - IL] ACETONITRIL MEDIANTE TRANSFORMACION CON HIDRURO DE BROMO Y CICLIDIZACION DE LOS PRODUCTOS INTERMEDIOS 4,4 - BIS(BROMETIL) DIHIDRO - 2 - FURANONA CON CINC. EL 5 - OXASPIRO [2.4]HEPTANO - 6 - ONA ES UN PRODUCTO INTERMEDIO PARA LA ELABORACION DE ANTAGONISTAS LEUCOTRIENO.
ES95105830T 1994-04-21 1995-04-19 Procedimiento y productos intermedios para la preparacion de 5-oxaespiro(2.4)heptan-6-ona. Expired - Lifetime ES2120098T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH123094 1994-04-21

Publications (1)

Publication Number Publication Date
ES2120098T3 true ES2120098T3 (es) 1998-10-16

Family

ID=4205533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95105830T Expired - Lifetime ES2120098T3 (es) 1994-04-21 1995-04-19 Procedimiento y productos intermedios para la preparacion de 5-oxaespiro(2.4)heptan-6-ona.

Country Status (8)

Country Link
US (1) US5486622A (es)
EP (1) EP0678515B1 (es)
JP (1) JPH07291957A (es)
AT (1) ATE168110T1 (es)
CA (1) CA2145735A1 (es)
DE (1) DE59502722D1 (es)
DK (1) DK0678515T3 (es)
ES (1) ES2120098T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103936703A (zh) * 2013-01-17 2014-07-23 上海朴颐化学科技有限公司 一种5-氧杂螺[2,4]庚-6-酮及其中间体的制备方法
CN103467276B (zh) * 2013-09-13 2015-05-06 天津速研医药科技有限公司 一种孟鲁司特钠侧链关键中间体的合成方法
JP7675618B2 (ja) * 2021-10-28 2025-05-13 株式会社クラレ ２－メチレン－１，３－プロパンジオールの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222344B1 (hu) * 1990-10-12 2003-06-28 Merck Frosst Canada & Co. Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására

Also Published As

Publication number Publication date
EP0678515B1 (de) 1998-07-08
CA2145735A1 (en) 1995-10-22
US5486622A (en) 1996-01-23
ATE168110T1 (de) 1998-07-15
DK0678515T3 (da) 1998-11-02
JPH07291957A (ja) 1995-11-07
DE59502722D1 (de) 1998-08-13
EP0678515A1 (de) 1995-10-25

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