ES2119987T3 - Derivados monoaceticos de los peptidos leu-phe-ala y ala-leu-phe y su uso en la identificacion y la destruccion de celulas tumorales y celulas infectadas por virus. - Google Patents

Derivados monoaceticos de los peptidos leu-phe-ala y ala-leu-phe y su uso en la identificacion y la destruccion de celulas tumorales y celulas infectadas por virus.

Info

Publication number
ES2119987T3
ES2119987T3 ES94830111T ES94830111T ES2119987T3 ES 2119987 T3 ES2119987 T3 ES 2119987T3 ES 94830111 T ES94830111 T ES 94830111T ES 94830111 T ES94830111 T ES 94830111T ES 2119987 T3 ES2119987 T3 ES 2119987T3
Authority
ES
Spain
Prior art keywords
phe
ala
leu
cells
monoacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94830111T
Other languages
English (en)
Inventor
Leonida Grippa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2119987T3 publication Critical patent/ES2119987T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LOS DERIVADOS MONOACETICOS DE TRIPEPTIDOS DE LEUCINA-FENILALANINAALANINA Y ALANINA-LEUCINA-FENILALANINA SON EFECTIVOS PARA ACTIVAR LOS LINFOCITOS NK PARA IDENTIFICAR Y DESTRUIR DIRECTAMENTE, ES DECIR SIN INTERFERENCIAS POR PARTE DEL SISTEMA INMUNE, CELULAS TUMORALES ANORMALES, CELULAS METASTATICAS, VIRUS Y CELULAS PORTADORAS DE VIRUS, LO QUE DA COMO RESULTADO UNA "INMUNOTERAPIA ACTIVA". LA INVENCION TAMBIEN SE REFIERE AL USO DE DICHOS TRIPEPTIDOS DE MONOACETILO PARA EL TRATAMIENTO Y PROFILAXIS DEL CANCER Y DE ENFERMEDADES VIRALES, ASI COMO A LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENE UNO O LOS DOS COMPUESTOS ANTEDICHOS, JUNTO CON UN PORTADOR ADECUADO Y, OPCIONALMENTE, CON TRAS SUSTANCIAS FARMACEUTICAMENTE ACTIVAS.
ES94830111T 1993-03-22 1994-03-16 Derivados monoaceticos de los peptidos leu-phe-ala y ala-leu-phe y su uso en la identificacion y la destruccion de celulas tumorales y celulas infectadas por virus. Expired - Lifetime ES2119987T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93830113 1993-03-22

Publications (1)

Publication Number Publication Date
ES2119987T3 true ES2119987T3 (es) 1998-10-16

Family

ID=8215135

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94830111T Expired - Lifetime ES2119987T3 (es) 1993-03-22 1994-03-16 Derivados monoaceticos de los peptidos leu-phe-ala y ala-leu-phe y su uso en la identificacion y la destruccion de celulas tumorales y celulas infectadas por virus.

Country Status (4)

Country Link
EP (1) EP0627444B1 (es)
AT (1) ATE167195T1 (es)
DE (1) DE69410881T2 (es)
ES (1) ES2119987T3 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1148005B (it) * 1981-04-09 1986-11-26 Leonida Grippa Tripeptide nelle sue sei combinazioni amminoacide alania fenilalanina e leucina in particolare fenil-alanina-alanina-leucina (p-a-l) aventela proprieta' di esaltare l'immunita' antivirale ed antitumorale
FR2569111B1 (fr) * 1984-08-16 1987-04-17 Rhone Poulenc Sante Nouveaux medicaments contenant des tripeptides
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DE69410881D1 (de) 1998-07-16
EP0627444B1 (en) 1998-06-10
DE69410881T2 (de) 1999-02-11
ATE167195T1 (de) 1998-06-15
EP0627444A1 (en) 1994-12-07

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