ES2117557A1 - Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. - Google Patents

Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.

Info

Publication number
ES2117557A1
ES2117557A1 ES09600481A ES9600481A ES2117557A1 ES 2117557 A1 ES2117557 A1 ES 2117557A1 ES 09600481 A ES09600481 A ES 09600481A ES 9600481 A ES9600481 A ES 9600481A ES 2117557 A1 ES2117557 A1 ES 2117557A1
Authority
ES
Spain
Prior art keywords
methylenedioxy
fluorophenyl
phenoxy
trans
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600481A
Other languages
English (en)
Other versions
ES2117557B1 (es
Inventor
Ambros Rafael Foguet
Ribera Santiago Gubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES09600481A priority Critical patent/ES2117557B1/es
Priority to TW086101103A priority patent/TW416941B/zh
Priority to ZA9701074A priority patent/ZA971074B/xx
Priority to US08/945,442 priority patent/US5973155A/en
Priority to EP97906144A priority patent/EP0823907B1/en
Priority to DE69700236T priority patent/DE69700236T2/de
Priority to NZ328932A priority patent/NZ328932A/en
Priority to BR9702123-7A priority patent/BR9702123A/pt
Priority to AU20940/97A priority patent/AU705887B2/en
Priority to AT97906144T priority patent/ATE180481T1/de
Priority to PCT/EP1997/001007 priority patent/WO1997031915A1/en
Priority to JP9530630A priority patent/JPH11504659A/ja
Priority to DK97906144T priority patent/DK0823907T3/da
Priority to IL12199597A priority patent/IL121995A/xx
Priority to CA002217171A priority patent/CA2217171C/en
Priority to NO19974958A priority patent/NO312549B1/no
Publication of ES2117557A1 publication Critical patent/ES2117557A1/es
Application granted granted Critical
Publication of ES2117557B1 publication Critical patent/ES2117557B1/es
Priority to GR990401765T priority patent/GR3030683T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVO PROCEDIMIENTO DE OBTENCION DE (-)-TRANS-N-P-FLUOROBENZOILMETIL-4-(P-FLUOROFENIL)-3-[[3,4-(METILENDIOXI)FENOXI]METIL]-PIPERIDINA. CONSISTE EN HACER REACCIONAR ACETATO DE (-)-TRANS-4-(P-FLUOROFENIL)-3-[[3,4-(METILENDIOXI)FENOXI]METIL]-PIPERIDINA CON 2-CLORO (O BROMO)-4''-FLUORO-ACETOFENONA, PUDIENDOSE AISLAR EL COMPUESTO RESULTANTE COMO SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE POR REACCION CON EL ACIDO CORRESPONDIENTE.
ES09600481A 1996-02-29 1996-02-29 Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. Expired - Fee Related ES2117557B1 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ES09600481A ES2117557B1 (es) 1996-02-29 1996-02-29 Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
TW086101103A TW416941B (en) 1996-02-29 1997-01-31 Process for preparing (-)-trans-n-p-fluoro-benzoylmethyl-4- (p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine
ZA9701074A ZA971074B (en) 1996-02-29 1997-02-10 Process for preparing (-)-trans-N-P-fluorobenzoylmethyl-4-(P-fluorophenyl)-3-[[3,4-(methylendioxy)phenoxy]methyl]-piperidine.
DK97906144T DK0823907T3 (da) 1996-02-29 1997-02-28 Fremgangsmåde til fremstilling af (-)-trans-N-p-fluorbenzoylmethyl-4-(p-fluorphenyl)-3-[[3,4-(methylendioxy)phenoxy]methyl]
DE69700236T DE69700236T2 (de) 1996-02-29 1997-02-28 Verfahren zur herstellung von (-)-trans-n-p-fluorbenzoylmethyl-4-(p-fluorphenyl)-3-[[3,4-(methylendioxy)phenoxy]methyl]-piperidin
NZ328932A NZ328932A (en) 1996-02-29 1997-02-28 Preparation of (-)-trans-n-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-[[3,4- (m ethylenedioxy)phenoxy]methyl]-piperidine
BR9702123-7A BR9702123A (pt) 1996-02-29 1997-02-28 Processo para a preparação de (-)- trans-n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3,4-(m etilenodióxi)fenóxi)metil)-piperidina
AU20940/97A AU705887B2 (en) 1996-02-29 1997-02-28 New process for preparing (-)-trans-N-p-fluor obenzoylmethyl-4-(p-fluorophenyl)-3-{{3,4-(methylenedioxy)ph noxy}methyl}-piperidine
US08/945,442 US5973155A (en) 1996-02-29 1997-02-28 Process for preparing (-)-trans-N-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-[[3,4-(methylened ioxy)phenoxy]methyl]-piperidine
PCT/EP1997/001007 WO1997031915A1 (en) 1996-02-29 1997-02-28 NEW PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE
JP9530630A JPH11504659A (ja) 1996-02-29 1997-02-28 （−）−ｔｒａｎｓ−Ｎ−ｐ−フルオロベンゾイルメチル−４−（ｐ−フルオロフェニル）−３−［［３，４−（メチレンジオキシ）フェノキシ］メチル］−ピペリジンの新規製造法
EP97906144A EP0823907B1 (en) 1996-02-29 1997-02-28 PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE
IL12199597A IL121995A (en) 1996-02-29 1997-02-28 Process for preparing (-)-trans-n-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-¬¬3,4-methylenedioxy)phenoxy¾methyl¾-piperidine
CA002217171A CA2217171C (en) 1996-02-29 1997-02-28 New process for preparing (-)-trans-n-p-fluorobenzoylmethyl-4-(p-fluorophenyl)-3-¢¢3,4-(methylenedioxy)phenoxy!methyl!-piperidine
AT97906144T ATE180481T1 (de) 1996-02-29 1997-02-28 Verfahren zur herstellung von (-)-trans-n-p- fluorbenzoylmethyl-4-(p-fluorphenyl)-3-((3,4- (methylendioxy)phenoxy>methyl>-piperidin
NO19974958A NO312549B1 (no) 1996-02-29 1997-10-27 Ny fremgangsmåte for fremstilling av (-)-trans-N-p- fluorbenzoylmetyl-4-(p-fluorfenyl)-3-[[3,4-(metylendioksy)fenoksy]metyl]-piperidin
GR990401765T GR3030683T3 (en) 1996-02-29 1999-07-05 NEW PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3- 3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09600481A ES2117557B1 (es) 1996-02-29 1996-02-29 Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.

Publications (2)

Publication Number Publication Date
ES2117557A1 true ES2117557A1 (es) 1998-08-01
ES2117557B1 ES2117557B1 (es) 1999-07-01

Family

ID=8293999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09600481A Expired - Fee Related ES2117557B1 (es) 1996-02-29 1996-02-29 Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.

Country Status (17)

Country Link
US (1) US5973155A (es)
EP (1) EP0823907B1 (es)
JP (1) JPH11504659A (es)
AT (1) ATE180481T1 (es)
AU (1) AU705887B2 (es)
BR (1) BR9702123A (es)
CA (1) CA2217171C (es)
DE (1) DE69700236T2 (es)
DK (1) DK0823907T3 (es)
ES (1) ES2117557B1 (es)
GR (1) GR3030683T3 (es)
IL (1) IL121995A (es)
NO (1) NO312549B1 (es)
NZ (1) NZ328932A (es)
TW (1) TW416941B (es)
WO (1) WO1997031915A1 (es)
ZA (1) ZA971074B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE03970B1 (et) 1997-06-10 2003-02-17 Synthon B.V. 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim
GB9808896D0 (en) * 1998-04-25 1998-06-24 Smithkline Beecham Plc Novel compound
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
CA2422055A1 (en) * 2000-09-11 2002-03-21 Sepracor, Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226574A1 (de) * 1984-07-20 1987-07-01 Bosch Gmbh Robert Magnetoresistiver sensor zur abgabe von elektrischen signalen.
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use
WO1995025732A1 (en) * 1994-03-18 1995-09-28 Ferrer Internacional, S.A. N-p-HALOBENZOYLMETHYL DERIVATIVES OF 4-(p-FLUOROPHENYL)-3-((3,4-METHYLENE-DIOXY)PHENOXY)METHYL)PIPERIDINE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2297550B (en) * 1995-02-06 1997-04-09 Smithkline Beecham Plc Paroxetine hydrochloride anhydrate substantially free of bound organic solvent
HUP9900318A3 (en) * 1995-05-17 2001-09-28 Novo Nordisk As Process for preparing 4-aryl-piperidine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226574A1 (de) * 1984-07-20 1987-07-01 Bosch Gmbh Robert Magnetoresistiver sensor zur abgabe von elektrischen signalen.
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use
WO1995025732A1 (en) * 1994-03-18 1995-09-28 Ferrer Internacional, S.A. N-p-HALOBENZOYLMETHYL DERIVATIVES OF 4-(p-FLUOROPHENYL)-3-((3,4-METHYLENE-DIOXY)PHENOXY)METHYL)PIPERIDINE

Also Published As

Publication number Publication date
DE69700236D1 (de) 1999-07-01
EP0823907B1 (en) 1999-05-26
BR9702123A (pt) 1999-12-28
DE69700236T2 (de) 1999-09-30
EP0823907A1 (en) 1998-02-18
TW416941B (en) 2001-01-01
CA2217171C (en) 2001-09-11
CA2217171A1 (en) 1997-09-04
AU2094097A (en) 1997-09-16
ATE180481T1 (de) 1999-06-15
JPH11504659A (ja) 1999-04-27
IL121995A (en) 2001-01-28
IL121995A0 (en) 1998-03-10
NZ328932A (en) 1998-04-27
GR3030683T3 (en) 1999-11-30
ZA971074B (en) 1997-11-18
NO312549B1 (no) 2002-05-27
NO974958L (no) 1997-10-27
NO974958D0 (no) 1997-10-27
AU705887B2 (en) 1999-06-03
WO1997031915A1 (en) 1997-09-04
DK0823907T3 (da) 1999-11-08
US5973155A (en) 1999-10-26
ES2117557B1 (es) 1999-07-01

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