ES2117551A1 - Naphthalene quinolines having leukotriene-antagonistic action - Google Patents
Naphthalene quinolines having leukotriene-antagonistic actionInfo
- Publication number
- ES2117551A1 ES2117551A1 ES09502547A ES9502547A ES2117551A1 ES 2117551 A1 ES2117551 A1 ES 2117551A1 ES 09502547 A ES09502547 A ES 09502547A ES 9502547 A ES9502547 A ES 9502547A ES 2117551 A1 ES2117551 A1 ES 2117551A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- quinolines
- leukotriene
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/54—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to novel naphthalene quinolines of formula (I), wherein the substituent containing A is bound to the 6- or 7-position of the 2-naphthol system -R<1>, R<2>, R<6> are independently hydrogen, fluorine, chlorine, bromine, -OCH3 or (C1-C4)-alkyl R<3> is hydrogen or methyl R<4>, R<5> are independently hydrogen, -OH, -NH2, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylamino, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylcarbonylamino, (C1-C4)-alkoxycarbonylalkyl, carbamoyl, carbamoylalkyl, N,N-dialkylcarbamoylalkyl -A- is a diradical -O-, -S-, -SO2-, -SO-, -SO2NR<7>- or -NR<7>SO2- wherein R<7> is hydrogen or (C1-C4)-alkyl B is a sulfur or oxygen atom or a -SO2- or -SO- group or a single bond D is a 5-tetrazolyl or -COOR<8> group, wherein R<8> is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms m is an integer from 0 to 4 n and p are integers from 0 to 6, with the proviso that n + p is less or equal to 6. Said compounds show a leukotriene-antagonistic activity, and they are valuable as anti-inflammatory and antiallergic medicaments or in the treatment of cardiovascular diseases.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9502547A ES2117551B1 (en) | 1995-12-29 | 1995-12-29 | NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. |
PCT/EP1996/005811 WO1997024331A1 (en) | 1995-12-29 | 1996-12-23 | Naphthalene quinolines having leukotriene-antagonistic action |
AU13783/97A AU1378397A (en) | 1995-12-29 | 1996-12-23 | Naphthalene quinolines having leukotriene-antagonistic action |
EP96944059A EP0874826A1 (en) | 1995-12-29 | 1996-12-23 | Naphthalene quinolines having leukotriene-antagonistic action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9502547A ES2117551B1 (en) | 1995-12-29 | 1995-12-29 | NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2117551A1 true ES2117551A1 (en) | 1998-08-01 |
ES2117551B1 ES2117551B1 (en) | 1999-04-01 |
Family
ID=8292586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9502547A Expired - Fee Related ES2117551B1 (en) | 1995-12-29 | 1995-12-29 | NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0874826A1 (en) |
AU (1) | AU1378397A (en) |
ES (1) | ES2117551B1 (en) |
WO (1) | WO1997024331A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1177176E (en) * | 1999-04-28 | 2006-08-31 | Aventis Pharma Gmbh | DERIVATIVES OF TRIARILIC ACIDS AS LIGANDS OF PPAR RECEPTORS. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
WO1989005294A1 (en) * | 1987-12-01 | 1989-06-15 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | Substituted quinolines |
WO1989012628A1 (en) * | 1988-06-21 | 1989-12-28 | Rorer International (Overseas) Inc. | Quinoline derivatives as antagonists of leukotriene d4 |
US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
ES2103181B1 (en) * | 1994-08-01 | 1998-04-01 | Menarini Lab | NAFTALENIC AMIDES WITH ANTAGONIST ACTION OF THE LEUKOTRENEES. |
ES2103180B1 (en) * | 1994-08-01 | 1998-04-01 | Menarini Lab | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
-
1995
- 1995-12-29 ES ES9502547A patent/ES2117551B1/en not_active Expired - Fee Related
-
1996
- 1996-12-23 WO PCT/EP1996/005811 patent/WO1997024331A1/en not_active Application Discontinuation
- 1996-12-23 AU AU13783/97A patent/AU1378397A/en not_active Abandoned
- 1996-12-23 EP EP96944059A patent/EP0874826A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
WO1989005294A1 (en) * | 1987-12-01 | 1989-06-15 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | Substituted quinolines |
WO1989012628A1 (en) * | 1988-06-21 | 1989-12-28 | Rorer International (Overseas) Inc. | Quinoline derivatives as antagonists of leukotriene d4 |
Also Published As
Publication number | Publication date |
---|---|
WO1997024331A1 (en) | 1997-07-10 |
ES2117551B1 (en) | 1999-04-01 |
AU1378397A (en) | 1997-07-28 |
EP0874826A1 (en) | 1998-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19980801 Kind code of ref document: A1 Effective date: 19980801 |
|
FD1A | Patent lapsed |
Effective date: 20051230 |