ES2103180A1 - Phenylacetamides having leukotriene-antagonistic action - Google Patents
Phenylacetamides having leukotriene-antagonistic actionInfo
- Publication number
- ES2103180A1 ES2103180A1 ES09401695A ES9401695A ES2103180A1 ES 2103180 A1 ES2103180 A1 ES 2103180A1 ES 09401695 A ES09401695 A ES 09401695A ES 9401695 A ES9401695 A ES 9401695A ES 2103180 A1 ES2103180 A1 ES 2103180A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- phenylacetamides
- leukotriene
- antagonistic action
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Abstract
Phenylacetamides of formula (I) wherein the substituent containing a -CONR<3>- is bound to the 3- or 4- position of the phenol system the substituent containing B is bound to the benzene ring at any free position R<1> is hydrogen, fluorine, chlorine or -OCH3 R<2> is hydrogen, fluorine, chlorine or bromine R<3> is hydrogen or methyl B is a 5-tetrazolyl group or -COOR<4>, wherein R<4> is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms m and n are integers from 0 to 6, with the proviso that m + n is less or equal to 6 have leukotriene antagonistic action.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9401695A ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
PCT/EP1995/002958 WO1996004246A1 (en) | 1994-08-01 | 1995-07-26 | Phenylacetamides having leukotriene-antagonistic action |
AU32219/95A AU3221995A (en) | 1994-08-01 | 1995-07-26 | Phenylacetamides having leukotriene-antagonistic action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9401695A ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2103180A1 true ES2103180A1 (en) | 1997-08-16 |
ES2103180B1 ES2103180B1 (en) | 1998-04-01 |
Family
ID=8287120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9401695A Expired - Fee Related ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3221995A (en) |
ES (1) | ES2103180B1 (en) |
WO (1) | WO1996004246A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2117551B1 (en) * | 1995-12-29 | 1999-04-01 | Menarini Lab | NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. |
FR2761687B1 (en) * | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS |
IT1320162B1 (en) * | 2000-02-09 | 2003-11-18 | Rotta Research Lab | DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
WO1989005294A1 (en) * | 1987-12-01 | 1989-06-15 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | Substituted quinolines |
EP0348155A1 (en) * | 1988-06-21 | 1989-12-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3900261A1 (en) * | 1988-05-31 | 1989-12-07 | Bayer Ag | SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES |
DE4129742A1 (en) * | 1991-09-06 | 1993-03-11 | Bayer Ag | HETEROCYCLICALLY SUBSTITUTED CHINOLYLMETHOXY-PHENYLACETAMIDE |
-
1994
- 1994-08-01 ES ES9401695A patent/ES2103180B1/en not_active Expired - Fee Related
-
1995
- 1995-07-26 WO PCT/EP1995/002958 patent/WO1996004246A1/en active Application Filing
- 1995-07-26 AU AU32219/95A patent/AU3221995A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
EP0315399A2 (en) * | 1987-11-03 | 1989-05-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same |
WO1989005294A1 (en) * | 1987-12-01 | 1989-06-15 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | Substituted quinolines |
EP0348155A1 (en) * | 1988-06-21 | 1989-12-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation |
Also Published As
Publication number | Publication date |
---|---|
ES2103180B1 (en) | 1998-04-01 |
WO1996004246A1 (en) | 1996-02-15 |
AU3221995A (en) | 1996-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970816 Kind code of ref document: A1 Effective date: 19970816 |
|
FD1A | Patent lapsed |
Effective date: 20060802 |