ES2103180B1 - PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. - Google Patents
PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.Info
- Publication number
- ES2103180B1 ES2103180B1 ES9401695A ES9401695A ES2103180B1 ES 2103180 B1 ES2103180 B1 ES 2103180B1 ES 9401695 A ES9401695 A ES 9401695A ES 9401695 A ES9401695 A ES 9401695A ES 2103180 B1 ES2103180 B1 ES 2103180B1
- Authority
- ES
- Spain
- Prior art keywords
- leucotrenees
- phenylacetamides
- hydrogen
- antagonist action
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FENILACETAMIDAS CON ACCION ANTAGONISTA DE LOS LEUCOTRIENOS. LA PRESENTE INVENCION SE REFIERE A NUEVAS FENILACETAMIDAS DE FORMULA I, FORMULA DONDE EL SUSTITUYENTE QUE CONTIENE A -CONR3- ESTA UNIDO A LA POSICION 3 O 4 DEL SISTEMA FENOLICO; R1 ES HIDROGENO, FLUOR, CLORO O -OCH3; R2 ES HIDROGENO, FLUOR, CLORO O BROMO; R3 ES HIDROGENO O METILO; B ES 5-TETRAZOLILO O -COOR4, R4 ES HIDROGENO, (C1-C4)-ALQUILO O FENILALQUILO; M Y N SON ENTEROS COMPRENDIDOS ENTRE 0 Y 6, CON LA CONDICION DE QUE M+N SEA MENOR O IGUAL A 6. DICHOS COMPUESTOS PRESENTAN UNA ACCION ANTAGONISTA DE LOS LEUCOTRIENOS, PUDIENDO SER UTILIZADOS COMO ANTIINFLAMATORIOS, ANTIALERGICOS O EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CARDIOVASCULAR.PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. THE PRESENT INVENTION REFERS TO NEW PHENYLACETAMIDES OF FORMULA I, FORMULA WHERE THE SUBSTITUTE CONTAINING -CONR3- IS ATTACHED TO POSITION 3 OR 4 OF THE PHENOLIC SYSTEM; R1 IS HYDROGEN, FLUORINE, CHLORINE OR -OCH3; R2 IS HYDROGEN, FLUORINE, CHLORINE OR BROMINE; R3 IS HYDROGEN OR METHYL; B IS 5-TETRAZOLYL OR -COOR4, R4 IS HYDROGEN, (C1-C4) -ALKYL OR PHENYLALKYL; MYN ARE WHOLE COMPRISED BETWEEN 0 AND 6, WITH THE CONDITION THAT M + N IS LESS THAN OR EQUAL TO 6. SUCH COMPOUNDS PRESENT AN ANTAGONISTIC ACTION OF THE LEUCOTRENEES, MAY BE USED AS ANTI-INFLAMMATORY, ANTI-ALLERGIC, AND TREATMENT TREATMENTS IN .
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9401695A ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
AU32219/95A AU3221995A (en) | 1994-08-01 | 1995-07-26 | Phenylacetamides having leukotriene-antagonistic action |
PCT/EP1995/002958 WO1996004246A1 (en) | 1994-08-01 | 1995-07-26 | Phenylacetamides having leukotriene-antagonistic action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9401695A ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2103180A1 ES2103180A1 (en) | 1997-08-16 |
ES2103180B1 true ES2103180B1 (en) | 1998-04-01 |
Family
ID=8287120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9401695A Expired - Fee Related ES2103180B1 (en) | 1994-08-01 | 1994-08-01 | PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3221995A (en) |
ES (1) | ES2103180B1 (en) |
WO (1) | WO1996004246A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2117551B1 (en) * | 1995-12-29 | 1999-04-01 | Menarini Lab | NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. |
FR2761687B1 (en) | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS |
IT1320162B1 (en) * | 2000-02-09 | 2003-11-18 | Rotta Research Lab | DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579866A (en) * | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
DE3900261A1 (en) * | 1988-05-31 | 1989-12-07 | Bayer Ag | SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES |
DE4129742A1 (en) * | 1991-09-06 | 1993-03-11 | Bayer Ag | HETEROCYCLICALLY SUBSTITUTED CHINOLYLMETHOXY-PHENYLACETAMIDE |
-
1994
- 1994-08-01 ES ES9401695A patent/ES2103180B1/en not_active Expired - Fee Related
-
1995
- 1995-07-26 WO PCT/EP1995/002958 patent/WO1996004246A1/en active Application Filing
- 1995-07-26 AU AU32219/95A patent/AU3221995A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3221995A (en) | 1996-03-04 |
ES2103180A1 (en) | 1997-08-16 |
WO1996004246A1 (en) | 1996-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970816 Kind code of ref document: A1 Effective date: 19970816 |
|
FD1A | Patent lapsed |
Effective date: 20060802 |