ES2117551B1 - NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. - Google Patents

NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.

Info

Publication number
ES2117551B1
ES2117551B1 ES9502547A ES9502547A ES2117551B1 ES 2117551 B1 ES2117551 B1 ES 2117551B1 ES 9502547 A ES9502547 A ES 9502547A ES 9502547 A ES9502547 A ES 9502547A ES 2117551 B1 ES2117551 B1 ES 2117551B1
Authority
ES
Spain
Prior art keywords
hydrogen
leukotrenees
quinolins
alkyl
naphthalenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9502547A
Other languages
Spanish (es)
Other versions
ES2117551A1 (en
Inventor
Casellas David Mauleon
Avellana Jaime Pascual
Perez M Luisa Garcia
Benet Albert Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9502547A priority Critical patent/ES2117551B1/en
Priority to PCT/EP1996/005811 priority patent/WO1997024331A1/en
Priority to AU13783/97A priority patent/AU1378397A/en
Priority to EP96944059A priority patent/EP0874826A1/en
Publication of ES2117551A1 publication Critical patent/ES2117551A1/en
Application granted granted Critical
Publication of ES2117551B1 publication Critical patent/ES2117551B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/54—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

QUINOLINAS NAFTALENICAS CON ACCION ANTAGONISTA DE LOS LEUCOTRIENOS, PROCEDIMIENTO PARA SU PREPARACION Y UTILIZACION DE LAS MISMAS. NUEVAS QUINOLINAS I EL SUSTITUYENTE QUE CONTIENE A ESTA UNIDO A LA POSICION 6 O 7 DEL SISTEMA 2-NAFTOLICO; R1, R2, R6 SON HIDROGENO, FLUOR, CLORO, BROMO, -OCH3 O (C1-C4)-ALQUILO; R3 ES HIDROGENO O METILO; R4, R5 SON HIDROGENO, -OH, -NH2 (C1-C4)-ALQUILCARBONILAMINO (C1-C4)-ALCOXICARBONILALQUILO, CARBAMOILO, CARBAMOILALQUILO, N,N-DIALQUILCARBAMOILALQUILO; -A- ES UN BIRRADICAL -O-, -S-, SO2-, -SO-, -SO2NR7- O -NR7SO2-, R7 ES HIDROGENO O UN (C1-C4)-ALQUILO; B ES OXIGENO O AZUFRE O -SO2- O UN ENLACE SENCILLO; D ES UN GRUPO 5-TETRAZOLILO O -COOR8-, DONDE R8 ES HIDROGENO, UN (C1-C4)-ALQUILO O UN GRUPO FENILALQUILO DE MENOS DE 10 ATOMOS DE CARBONO; M ES UN ENTERO 0-4; N Y P SON 0-6, SIENDO N+P MENOR O IGUAL A 6. PRESENTAN ACCION ANTAGONISTA DE LOS LEUCOTRIENOS.NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. NEW QUINOLINS AND THE SUBSTITUTE CONTAINING THIS UNIT AT POSITION 6 OR 7 OF THE 2-NAFTOLIC SYSTEM; R1, R2, R6 ARE HYDROGEN, FLUORINE, CHLORINE, BROMINE, -OCH3 O (C1-C4) -ALKYL; R3 IS HYDROGEN OR METHYL; R4, R5 ARE HYDROGEN, -OH, -NH2 (C1-C4) -ALKYL CARBONYLAMYL (C1-C4) -ALCOXYCARBONYLALKYL, N, N-DIALKYL CARBAMOYLALKYL; -A- IS A BIRRADICAL -O-, -S-, SO2-, -SO-, -SO2NR7- OR -NR7SO2-, R7 IS HYDROGEN OR A (C1-C4) -ALKYL; B IS OXYGEN OR SULFUR OR -SO2- OR A SIMPLE LINK; D IS A GROUP 5-TETRAZOLYL OR -COOR8-, WHERE R8 IS HYDROGEN, A (C1-C4) -ALKYL OR A PHENYLALKYL GROUP OF LESS THAN 10 CARBON ATOMS; M IS AN INTEGER 0-4; N AND P ARE 0-6, BEING N + P LESS THAN OR EQUAL TO 6. THEY PRESENT ANTAGONISTIC ACTION OF THE LEUKOTRENEES.

ES9502547A 1995-12-29 1995-12-29 NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME. Expired - Fee Related ES2117551B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9502547A ES2117551B1 (en) 1995-12-29 1995-12-29 NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.
PCT/EP1996/005811 WO1997024331A1 (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action
AU13783/97A AU1378397A (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action
EP96944059A EP0874826A1 (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9502547A ES2117551B1 (en) 1995-12-29 1995-12-29 NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.

Publications (2)

Publication Number Publication Date
ES2117551A1 ES2117551A1 (en) 1998-08-01
ES2117551B1 true ES2117551B1 (en) 1999-04-01

Family

ID=8292586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9502547A Expired - Fee Related ES2117551B1 (en) 1995-12-29 1995-12-29 NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.

Country Status (4)

Country Link
EP (1) EP0874826A1 (en)
AU (1) AU1378397A (en)
ES (1) ES2117551B1 (en)
WO (1) WO1997024331A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543065A (en) * 1999-04-28 2002-12-17 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Triaryl acid derivatives as PPAP receptor ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084575A (en) * 1987-07-31 1992-01-28 American Home Products Corporation Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
ES2103181B1 (en) * 1994-08-01 1998-04-01 Menarini Lab NAFTALENIC AMIDES WITH ANTAGONIST ACTION OF THE LEUKOTRENEES.
ES2103180B1 (en) * 1994-08-01 1998-04-01 Menarini Lab PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Also Published As

Publication number Publication date
WO1997024331A1 (en) 1997-07-10
AU1378397A (en) 1997-07-28
ES2117551A1 (en) 1998-08-01
EP0874826A1 (en) 1998-11-04

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