ES2117045T3 - Peptidos angiogenicos. - Google Patents

Peptidos angiogenicos.

Info

Publication number
ES2117045T3
ES2117045T3 ES92904736T ES92904736T ES2117045T3 ES 2117045 T3 ES2117045 T3 ES 2117045T3 ES 92904736 T ES92904736 T ES 92904736T ES 92904736 T ES92904736 T ES 92904736T ES 2117045 T3 ES2117045 T3 ES 2117045T3
Authority
ES
Spain
Prior art keywords
peptides
angiogenic
healing
platelet factor
repair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92904736T
Other languages
English (en)
Inventor
Russel B Whitman
Robert Wohl
Ronald G Duff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curative Technologies Inc
Original Assignee
Curative Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curative Technologies Inc filed Critical Curative Technologies Inc
Application granted granted Critical
Publication of ES2117045T3 publication Critical patent/ES2117045T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A PEPTIDOS Y DERIVADOS DE LOS PEPTIDOS RELATIVOS AL FACTOR DE PLAQUETA 4 QUE EXHIBEN ACTIVIDADES ANGIOGENICAS, A COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS PEPTIDOS Y A METODOS PARA FAVORECER LA ANGIOGENESIS UTILIZANDO DICHOS PEPTIDOS. ESTA BASADA, EN PARTE, EN EL DESCUBRIMIENTO DE QUE UN OCTAPEPTIDO DERIVADO DEL FACTOR DE PLAQUETA 4 Y SIETE PEPTIDOS RELACIONADOS ESTRUCTURALMENTE (DESCRITOS EN LA FIGURA 1), FUERON CAPACES DE INDUCIR UNA RESPUESTA ANGIOGENICA IN VIVO MEDIDA POR NEOVASCULARIZACION EN MUESTRA DE IMPLANTE CORNEAL EN CONEJO Y POR MEDICION DE LA QUIMOATRACCION DE CELULA ENDOTELIAL CAPILAR. ESTOS OCHO PEPTIDOS REPRESENTAN REALIZACIONES ESPECIFICAS NO LIMITANTES DE LA PRESENTE INVENCION. LOS PEPTIDOS ANGIOGENICOS DE LA INVENCION, PUEDEN SER PARTICULARMENTE UTILES EN EL FAVORECIMIENTO DE LA CICATRIZACION DE HERIDAS, INCLUYENDO LA CICATRIZACION INCISIONAL, EL RESTABLECIMIENTO DE HUESOS, LA CICATRIZACION DE QUEMADURAS Y EL RESTABLECIMIENTO POST-INFARTO EN LESIONES DEL MIOCARDIO O DEL SISTEMA NERVIOSO CENTRAL, ASI COMO LA ASIMILACION DE TEJIDOS INJERTADOS, EN PARTICULAR, EN PERSONAS QUE SUFREN INSUFICIENCIA VASCULAR, TAL COMO LOS PACIENTES DIABETICOS.
ES92904736T 1990-12-21 1991-12-20 Peptidos angiogenicos. Expired - Lifetime ES2117045T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63182390A 1990-12-21 1990-12-21

Publications (1)

Publication Number Publication Date
ES2117045T3 true ES2117045T3 (es) 1998-08-01

Family

ID=24532905

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92904736T Expired - Lifetime ES2117045T3 (es) 1990-12-21 1991-12-20 Peptidos angiogenicos.

Country Status (10)

Country Link
US (1) US5470831A (es)
EP (1) EP0563329B1 (es)
JP (1) JP3159705B2 (es)
KR (1) KR100204400B1 (es)
AT (1) ATE164167T1 (es)
CA (1) CA2098921C (es)
DE (1) DE69129121T2 (es)
DK (1) DK0563329T3 (es)
ES (1) ES2117045T3 (es)
WO (1) WO1992011021A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
WO1995000543A1 (en) * 1993-06-18 1995-01-05 Curative Technologies, Inc. Anti-inflammatory peptides
WO1997010839A1 (en) * 1995-09-19 1997-03-27 Texas Biotechnology Corporation Compositions and methods for inhibiting the binding of pecam
US6693081B2 (en) * 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
AU721034B2 (en) 1996-02-15 2000-06-22 Biosense, Inc. Catheter based surgery
US6443974B1 (en) 1996-07-28 2002-09-03 Biosense, Inc. Electromagnetic cardiac biostimulation
US6342051B1 (en) * 1997-06-12 2002-01-29 Gholam A. Peyman Treatment of anoxic tissue with angiogenesis-inducing implants
ES2255155T3 (es) 1998-02-05 2006-06-16 Biosense Webster, Inc. Dispositivo para la administracion intracardiaca de farmacos.
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US6329164B1 (en) * 1999-03-18 2001-12-11 Neuro Probe, Incorporated Method for using a cell activity assay apparatus
US7261881B1 (en) 1999-05-20 2007-08-28 Yale University Modulation of angiogenesis and wound healing
FR2814076B1 (fr) * 2000-09-21 2002-12-20 Centre Nat Rech Scient Agent angiogenique et ses utilisations
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
CA2498717A1 (en) 2002-09-13 2004-03-25 Ocular Sciences, Inc. Devices and methods for improving vision
AU2003291871A1 (en) * 2002-12-05 2004-06-23 Osteopharm Inc. Bone growth factor
US20060275303A1 (en) * 2003-02-27 2006-12-07 Robert Bals Modulating angiogenesis using LL-37/HCAP-18
US20050191286A1 (en) * 2004-02-09 2005-09-01 Gandy James B. Lyophilized platelet rich plasma for the use in wound healing (chronic or acute) and bone or tissue grafts or repair
WO2005108463A2 (en) 2004-05-03 2005-11-17 Nektar Therapeutics Al, Corporation Branched polyethylen glycol derivates comprising an acetal or ketal branching point
WO2005116729A2 (en) 2004-05-20 2005-12-08 Coopervision, Inc., Corneal onlays and wavefront aberration correction to enhance vision
FR2872040B1 (fr) * 2004-06-23 2006-09-22 Centre Nat Rech Scient Cnrse Utilisation cosmetique d'au moins un tetrapeptide naturel ac-n-ser-asp-lys-pro- ou un de ses analogues en tant qu'agent antivieillissement et restructurant de la peau
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US20060142198A1 (en) * 2004-07-02 2006-06-29 Wound Care Partners Llc Compositions for treating wounds and processes for their preparation
US20060004189A1 (en) * 2004-07-02 2006-01-05 James Gandy Compositions for treating wounds and processes for their preparation
US7883520B2 (en) 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
CA2698754A1 (en) * 2007-09-11 2009-03-19 Dorian Bevec Use of a peptide as a therapeutic agent
US20100184675A1 (en) * 2007-09-11 2010-07-22 Dorian Bevec Use of glucagon (1-29) alone or in combination with neuropeptide w30 as a therapeutic agent
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
WO2010033207A1 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of therapeutic peptides
KR101335203B1 (ko) 2010-03-26 2013-11-29 숙명여자대학교산학협력단 혈관신생촉진용 펩타이드 및 이의 용도
WO2012122524A1 (en) 2011-03-09 2012-09-13 Worden Charles E Wound healant system and method of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645828A (en) * 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
US5086164A (en) * 1989-01-10 1992-02-04 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
WO1992013874A2 (en) * 1991-01-02 1992-08-20 Fox Chase Cancer Center Angiogenic peptides

Also Published As

Publication number Publication date
US5470831A (en) 1995-11-28
KR100204400B1 (ko) 1999-06-15
EP0563329B1 (en) 1998-03-18
WO1992011021A1 (en) 1992-07-09
DE69129121D1 (de) 1998-04-23
EP0563329A4 (es) 1994-12-21
CA2098921C (en) 2000-12-05
KR930703004A (ko) 1993-11-29
EP0563329A1 (en) 1993-10-06
ATE164167T1 (de) 1998-04-15
JP3159705B2 (ja) 2001-04-23
JPH06504064A (ja) 1994-05-12
DK0563329T3 (da) 1998-12-07
CA2098921A1 (en) 1992-06-22
DE69129121T2 (de) 1998-11-19

Similar Documents

Publication Publication Date Title
ES2117045T3 (es) Peptidos angiogenicos.
Uludag et al. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: a correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model
AU753816B2 (en) Recombinant fibronectin-based extracellular matrix for wound healing
US5108989A (en) Method of predisposing mammals to accelerated tissue repair
EP0535091B1 (en) Osteoinductive pharmaceutical formulations
ATE142693T1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
US5155038A (en) Use of thrombospondin to promote wound healing
US7147839B2 (en) Methods for evaluating tissue morphogenesis and activity
McPherson The utility of collagen-based vehicles in delivery of growth factors for hard and soft tissue wound repair
EP0437281A1 (en) Composition comprising acidic fibroblast growth factor (aFGF)
US20050143312A1 (en) Compositions and methods for promoting myocardial and peripheral angiogenesis
BRPI0720874B1 (pt) composições compreendendo peptídeos bioativos curtos para modulação celular e imunológica
DE69634564D1 (de) Peptide des tsp-i-rezeptors cd36 zur behandlung von krankheiten welche durch eine fehlregulation von tgf-beta1 verursacht werden
CA2321933C (en) Fibronectin peptides-based extracellular matrix for wound healing
US6180610B1 (en) Tetrapeptide
JP3229643B2 (ja) 育毛促進剤
Joerring et al. Changes in collagen metabolites in serum after cemented hip and knee arthroplasty
DiPietro et al. The Role of Thrombospondin in Angiogenesis
DiPietro Thrombospondin and Angiogenesis
JPH0680694A (ja) 創傷治癒に活性のあるポリペプチド・ポリマーイオン複合体
JPH0827020A (ja) 破骨細胞形成促進及び骨吸収剤
Pang et al. Articles in PresS. J Appl Physiol (October 28, 2010). doi: 10.1152/japplphysiol. 00945.2010
RU2002106483A (ru) Новый класс физиологически активных гликопротеинов
Biloklytska et al. The Osteoinductive Properties And Influence of “Emdogain”(Straumann) on Colony-Forming Properties of Human Osteogenous Progenitor Bone Marrow Cells Ex vivo
JPH07265069A (ja) ヒト歯根膜細胞接着因子

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 563329

Country of ref document: ES