ES2115749T3 - Procedimiento para la produccion y cultivo de avermectinas. - Google Patents

Procedimiento para la produccion y cultivo de avermectinas.

Info

Publication number
ES2115749T3
ES2115749T3 ES93900643T ES93900643T ES2115749T3 ES 2115749 T3 ES2115749 T3 ES 2115749T3 ES 93900643 T ES93900643 T ES 93900643T ES 93900643 T ES93900643 T ES 93900643T ES 2115749 T3 ES2115749 T3 ES 2115749T3
Authority
ES
Spain
Prior art keywords
branched
avermectins
chain
activity
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900643T
Other languages
English (en)
Inventor
Edmund William Hafner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2115749T3 publication Critical patent/ES2115749T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/03—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A STREPTOMYCES AVERMITILIS QUE NO TIENEN LA ACTIVIDAD DE LA TRANSAMINASA DE AMINOACIDOS DE CADENA RAMIFICADA, LA ACTIVIDAD BIOSINTENTICA DE ACIDOS 2-OXO DE CADENA RAMIFICADA NI, OPCIONALMENTE Y PREFERENTEMENTE, LA ACTIVIDAD DE LA TRANSFERASA DE B-O-METILO DE AVERMECTINA, A LOS METODOS PARA LA PREPARACION DE LOS MISMOS Y AL USO DE LOS MISMOS PARA LA PRODUCCION DE AVERMECTINAS NATURALES O NO NATURALES A PARTIR DE PRECURSORES DE ACIDOS GRASOS DE CADENA RAMIFICADA O DE ACIDO 2-OXO DE CADENA RAMIFICADA. TALES AVERMECTINAS SON UTILES COMO PARASITICIDAS.
ES93900643T 1992-03-25 1992-11-30 Procedimiento para la produccion y cultivo de avermectinas. Expired - Lifetime ES2115749T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/857,540 US6103504A (en) 1992-03-25 1992-03-25 Process for production of avermectins and cultures therefor

Publications (1)

Publication Number Publication Date
ES2115749T3 true ES2115749T3 (es) 1998-07-01

Family

ID=25326228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900643T Expired - Lifetime ES2115749T3 (es) 1992-03-25 1992-11-30 Procedimiento para la produccion y cultivo de avermectinas.

Country Status (10)

Country Link
US (1) US6103504A (es)
EP (1) EP0640142B1 (es)
JP (1) JP2858951B2 (es)
AT (1) ATE166394T1 (es)
BR (1) BR9207110A (es)
CA (1) CA2131284C (es)
DE (1) DE69225610T2 (es)
DK (1) DK0640142T3 (es)
ES (1) ES2115749T3 (es)
WO (1) WO1993019194A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056939A1 (fr) * 1997-06-09 1998-12-17 Vladimir Alexandrovich Mosin Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux
CN102676618B (zh) * 2012-06-07 2013-11-27 浙江升华拜克生物股份有限公司 一种发酵生产阿维菌素的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4134973A (en) * 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
US4328335A (en) * 1979-08-13 1982-05-04 Merck & Co., Inc. Process for the interconversion of C-076 compounds
US4285963A (en) * 1980-08-07 1981-08-25 Merck & Co., Inc. Novel derivatives of C-076 compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
US4333925A (en) * 1981-05-11 1982-06-08 Merck & Co., Inc. Derivatives of C-076 compounds
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
IT1182857B (it) * 1984-09-14 1987-10-05 Glaxo Group Ltd Composti antibiotici, composizioni antiparassitarie che li contengono e procedimento per prepararli ed applicarli
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB8502925D0 (en) * 1985-02-05 1985-03-06 Ici Plc Macrocyclic lactones
ES8802229A1 (es) * 1985-04-30 1988-04-16 Glaxo Group Ltd Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
EP0235085A1 (de) * 1986-02-20 1987-09-02 Ciba-Geigy Ag 13-Beta-Zuckerderivate von Milbemycinen, deren Herstellung und Verwendung gegen Ekto-und Endoparasiten am Nutztier oder an der Nutzpflanze
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
ES2058244T3 (es) * 1987-01-23 1994-11-01 Pfizer Procedimiento para produccion de avermectinas y cultivos para el mismo.
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5077278A (en) * 1987-01-23 1991-12-31 Pfizer Inc. Non-natural demethylavermectins compositions and method of use
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Also Published As

Publication number Publication date
US6103504A (en) 2000-08-15
DE69225610D1 (de) 1998-06-25
ATE166394T1 (de) 1998-06-15
EP0640142A1 (en) 1995-03-01
EP0640142B1 (en) 1998-05-20
JPH07501454A (ja) 1995-02-16
DE69225610T2 (de) 1998-09-17
JP2858951B2 (ja) 1999-02-17
CA2131284C (en) 1998-01-06
DK0640142T3 (da) 1998-10-07
BR9207110A (pt) 1995-12-12
CA2131284A1 (en) 1993-09-30
WO1993019194A1 (en) 1993-09-30

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