ES2115656T3 - Analogos de tocoferol cardioprotectores. - Google Patents

Analogos de tocoferol cardioprotectores.

Info

Publication number
ES2115656T3
ES2115656T3 ES92402656T ES92402656T ES2115656T3 ES 2115656 T3 ES2115656 T3 ES 2115656T3 ES 92402656 T ES92402656 T ES 92402656T ES 92402656 T ES92402656 T ES 92402656T ES 2115656 T3 ES2115656 T3 ES 2115656T3
Authority
ES
Spain
Prior art keywords
cardioprotectors
tocoferol
analogs
cardioprotectoral
phosphony
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92402656T
Other languages
English (en)
Spanish (es)
Inventor
J Martin Grisar
Margaret A Petty
Frank Bolkenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2115656T3 publication Critical patent/ES2115656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Noodles (AREA)
  • Credit Cards Or The Like (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Fire-Detection Mechanisms (AREA)
ES92402656T 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores. Expired - Lifetime ES2115656T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91402630A EP0535283A1 (en) 1991-10-02 1991-10-02 Cardioprotective tocopherol analogs

Publications (1)

Publication Number Publication Date
ES2115656T3 true ES2115656T3 (es) 1998-07-01

Family

ID=8208620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92402656T Expired - Lifetime ES2115656T3 (es) 1991-10-02 1992-09-29 Analogos de tocoferol cardioprotectores.

Country Status (17)

Country Link
EP (2) EP0535283A1 (en:Method)
JP (1) JP3230699B2 (en:Method)
KR (1) KR100253108B1 (en:Method)
AT (1) ATE163421T1 (en:Method)
AU (1) AU652077B2 (en:Method)
CA (1) CA2079289C (en:Method)
DE (1) DE69224501T2 (en:Method)
DK (1) DK0536036T3 (en:Method)
ES (1) ES2115656T3 (en:Method)
FI (1) FI105552B (en:Method)
GR (1) GR3026242T3 (en:Method)
HU (1) HU215123B (en:Method)
IL (1) IL103305A0 (en:Method)
NO (1) NO923840L (en:Method)
NZ (1) NZ244549A (en:Method)
TW (1) TW224970B (en:Method)
ZA (1) ZA927429B (en:Method)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
ES2244104T3 (es) * 1997-11-25 2005-12-01 Antipodean Biotechnology Limited Antioxidantes orientados mitocondrialmente.
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
US8008345B2 (en) 2001-07-27 2011-08-30 Vital Health Sciences Pty. Ltd. Dermal therapy using phosphate derivatives of electron transfer agents
ES2314010T3 (es) * 2002-06-19 2009-03-16 Cognis Ip Management Gmbh Empleo de mazclas de principios activos para la obtencion de un medicamento contra la artritis reumatoide.
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
CN1839142B (zh) 2003-08-22 2010-06-16 澳新制药公司 用作靶向线粒体的抗氧化剂的线粒体醌衍生物
US7514461B2 (en) 2003-09-19 2009-04-07 Edison Pharmaceuticals, Inc. Chroman derivatives
WO2005084678A1 (en) 2004-03-03 2005-09-15 Vital Health Sciences Pty Ltd Alkaloid formulations
EP1893159B1 (en) 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. A carrier comprising one or more di- and/or monophosphate derivatives of electron transfer agents
US7813042B2 (en) 2005-09-12 2010-10-12 Sharp Kabushiki Kaisha Multiple-view directional display
WO2008029891A1 (en) 2006-09-07 2008-03-13 Sharp Kabushiki Kaisha Image display device, electronic device, and parallax barrier element
EP2531047B1 (en) 2010-02-05 2024-11-13 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
JP5806287B2 (ja) 2010-03-30 2015-11-10 フォスファジェニクス リミティド 経皮送達パッチ
EP2685992A4 (en) 2011-03-15 2014-09-10 Phosphagenics Ltd AMINOCHINOLINE AS A KINASEHEMMER
CN108601732A (zh) 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
KR102647670B1 (ko) 2016-12-21 2024-03-15 아베초 바이오테크놀로지 리미티드 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5500444A (en) 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
US5135945A (en) 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs

Also Published As

Publication number Publication date
NO923840L (no) 1993-04-05
DK0536036T3 (da) 1998-03-16
AU2538392A (en) 1993-04-08
EP0536036A1 (en) 1993-04-07
AU652077B2 (en) 1994-08-11
NO923840D0 (no) 1992-10-01
DE69224501D1 (de) 1998-04-02
DE69224501T2 (de) 1998-06-25
CA2079289C (en) 2003-02-18
JP3230699B2 (ja) 2001-11-19
FI105552B (fi) 2000-09-15
CA2079289A1 (en) 1993-04-03
ZA927429B (en) 1993-04-07
GR3026242T3 (en) 1998-05-29
TW224970B (en:Method) 1994-06-11
EP0536036B1 (en) 1998-02-25
EP0535283A1 (en) 1993-04-07
JPH05310763A (ja) 1993-11-22
KR100253108B1 (ko) 2000-05-01
FI924424A0 (fi) 1992-10-01
ATE163421T1 (de) 1998-03-15
HUT62592A (en) 1993-05-28
IL103305A0 (en) 1993-02-21
FI924424L (fi) 1993-04-03
HU9203134D0 (en) 1992-12-28
HU215123B (hu) 1998-09-28
NZ244549A (en) 1994-07-26

Similar Documents

Publication Publication Date Title
ES2115656T3 (es) Analogos de tocoferol cardioprotectores.
ES2111092T3 (es) Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
MX9301129A (es) Nuevas ciclosporinas y composiciones farmaceuticas que las contienen.
ES2176212T3 (es) Eteres de fosfonooximetilicos o metiltiometilicos de derivados de taxano como agentes antitumorales.
SV1995000042A (es) Heteroaril-oxazolidinonas de 5 eslabones ref. le a 30523-sv
ES542322A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
ES2106965T3 (es) Nuevas 4-aza-5alfa-androstan-3-onas 7beta-sustituidas como inhibidores de 5alfa-reductasa.
ES2138956T3 (es) Imidazoquinoxalinonas, sus analogos aza y procedimiento para su preparacion.
ES2119831T3 (es) 7-(sustituido)-9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas.
ES2030409T3 (es) Procedimiento para preparar y purificar compuestos termolabiles .
ES2098140T3 (es) Liosferas que contienen gonadotropina.
ES2068179T3 (es) Benzo(5,6)-ciclohepta-piridinas, composiciones y metodo de uso.
ES2040727T3 (es) Un proceso para preparar una formulacion en aerosol en solucion de un analogo.
ES2136725T3 (es) Utilizacion de 2-amino-6-n-propil-amino-4,5,6,7-tetrahidrobenzotiazol (pramipexol) como medicamento con efecto antidepresivo.
ES2071169T3 (es) 1-indolilalquil-4-(alcoxi-pirimidinil)piperazinas.
IL64292A0 (en) D-homosteroids,their manufacture and pharmaceutical compositions containing them
ES2071674T3 (es) Analogos de tocoferol cardioprotectores.
IT8322080A0 (it) Derivati del n-fenilpirazolo utili come erbicidi.
ES2069921T3 (es) Antagonistas del nmda.
ES2007310A4 (es) 3-(4-nitrofenoxi)pirazoles sustituidos y su uso como herbicidas.
AR059965A2 (es) Uso de 8,9-dehidroestrona para la preparacion de un medicamento antioxidante
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
ES2059396T3 (es) Derivados de indeno y metodos.
ES2076141T3 (es) 5-aril-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
ES2081916T3 (es) Delta-lactonas naturales y procedimiento para su fabricacion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 536036

Country of ref document: ES