ES2114117T3 - Acidos fenilalcan(en)oicos con actividad antagonista del leucotrieno b4. - Google Patents

Acidos fenilalcan(en)oicos con actividad antagonista del leucotrieno b4.

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Publication number
ES2114117T3
ES2114117T3 ES94118144T ES94118144T ES2114117T3 ES 2114117 T3 ES2114117 T3 ES 2114117T3 ES 94118144 T ES94118144 T ES 94118144T ES 94118144 T ES94118144 T ES 94118144T ES 2114117 T3 ES2114117 T3 ES 2114117T3
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Spain
Prior art keywords
fenilalcan
leucotrene
antagonist activity
oic acids
oic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES94118144T
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English (en)
Inventor
Mitoshi Konno
Takahiko Nakae
Nobuyuki Hamanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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Publication date
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Publication of ES2114117T3 publication Critical patent/ES2114117T3/es
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    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07C2601/14—The ring being saturated

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Abstract

LOS ACIDOS FENILALCAN(EN)OICOS DE LA FORMULA: (I) EN DONDE A ES I) -NHCOCH(OH) 4EN UN ANTAGONISMO SOBRE LEUCOTRIENO B4, Y ADEMAS, SE USAN PARA LA PREVENCION Y TRATAMIENTO DE DIVERSAS ENFERMEDADES INDUCIDAS POR LEUCOTRIENO B4.
ES94118144T 1989-06-27 1990-05-16 Acidos fenilalcan(en)oicos con actividad antagonista del leucotrieno b4. Expired - Lifetime ES2114117T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16421389 1989-06-27
JP31054589 1989-12-01
JP179990 1990-01-09
EP90109294A EP0405116B1 (en) 1989-06-27 1990-05-16 Phenylalkan(en)oic acids

Publications (1)

Publication Number Publication Date
ES2114117T3 true ES2114117T3 (es) 1998-05-16

Family

ID=27275078

Family Applications (3)

Application Number Title Priority Date Filing Date
ES90109294T Expired - Lifetime ES2083396T3 (es) 1989-06-27 1990-05-16 Acidos fenilalcan(en)oicos.
ES94118144T Expired - Lifetime ES2114117T3 (es) 1989-06-27 1990-05-16 Acidos fenilalcan(en)oicos con actividad antagonista del leucotrieno b4.
ES94108324T Expired - Lifetime ES2102097T3 (es) 1989-06-27 1990-05-16 Acidos fenilalcan(quen)oicos con actividad antagonista del leucotrieno b4.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES90109294T Expired - Lifetime ES2083396T3 (es) 1989-06-27 1990-05-16 Acidos fenilalcan(en)oicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94108324T Expired - Lifetime ES2102097T3 (es) 1989-06-27 1990-05-16 Acidos fenilalcan(quen)oicos con actividad antagonista del leucotrieno b4.

Country Status (10)

Country Link
US (2) US5086065A (es)
EP (3) EP0405116B1 (es)
JP (2) JPH0739369B2 (es)
KR (3) KR0143404B1 (es)
AT (3) ATE131154T1 (es)
CA (1) CA2019335C (es)
DE (3) DE69031959T2 (es)
DK (3) DK0652208T3 (es)
ES (3) ES2083396T3 (es)
GR (3) GR3018510T3 (es)

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US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
DE4224402A1 (de) * 1992-07-21 1994-01-27 Schering Ag Neue Pyridin-Derivate mit Leukotrien-B¶4¶-antagonistischer Wirkung
MX9702734A (es) * 1994-10-13 1997-06-28 Pfizer Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
KR100232341B1 (ko) * 1994-10-13 2000-07-01 디. 제이. 우드 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
US5559150A (en) * 1995-06-06 1996-09-24 3-Dimensional Pharmaceuticals, Inc. N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
CA2265996A1 (en) 1996-09-26 1998-04-02 Roger Aki Fujimoto Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
EP0891772A3 (en) * 1997-06-18 1999-05-19 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatic disease comprising nonsteroidal anti-inflamatory drug and phenylpropionic acid derivative
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
US7507531B2 (en) 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
RU2371436C2 (ru) 2003-09-01 2009-10-27 Оно Фармасьютикал Ко., Лтд. СОЕДИНЕНИЯ НА ОСНОВЕ БЕНЗОКСАЗИНА И ИНДОЛА, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ В ОТНОШЕНИИ РЕЦЕПТОРА cysLT2
EP1670445A2 (en) * 2003-09-17 2006-06-21 Decode Genetics EHF. Methods of preventing or treating recurrence of myocardial infarction
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
PT1988085E (pt) * 2006-02-21 2015-02-05 Toyama Chemical Co Ltd Processo para a produção de éster de propionato de 3-[5-[4-(ciclopentiloxi)-2-hidroxibenzoil]-2-[(3- hidroxi-1,2-benzisoxazol-6-il)metoxi]fenilo] e produtos intermédios para o processo
TWI469965B (zh) 2008-12-22 2015-01-21 Ono Pharmaceutical Co 乙炔基吲哚化合物
KR20130112715A (ko) 2010-06-21 2013-10-14 오노 야꾸힝 고교 가부시키가이샤 4,4''-[4-플루오로-7-(｛4-[4-(3-플루오로-2-메틸페닐)부톡시]페닐｝에티닐)-2-메틸-1h-인돌-1,3-디일]디부탄산, 4,4''-[2-메틸-7-(｛4-[4-(펜타플루오로페닐)부톡시]페닐｝에티닐)-1h-인돌-1,3-디일]디부탄산 및 4,4''-[4-플루오로-2-메틸-7-(｛4-[4-(2,3,4,6-테트라플루오로페닐)부톡시]페닐｝에티닐)-1h-인돌-1,3-디일]디부탄산의 신규 결정형
WO2016149126A1 (en) 2015-03-13 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema

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Publication number Priority date Publication date Assignee Title
GB8311678D0 (en) * 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
CA1315279C (en) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Anti-inflammatory agents
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents

Also Published As

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US5155104A (en) 1992-10-13
DK0652208T3 (da) 1998-09-14
JPH0739369B2 (ja) 1995-05-01
US5086065A (en) 1992-02-04
DE69023960T2 (de) 1996-10-17
ES2102097T3 (es) 1997-07-16
ES2083396T3 (es) 1996-04-16
GR3018510T3 (en) 1996-03-31
DE69023960D1 (de) 1996-01-18
DE69031959T2 (de) 1998-06-04
ATE162181T1 (de) 1998-01-15
EP0405116A3 (en) 1992-04-15
JPH03261752A (ja) 1991-11-21
DE69031959D1 (de) 1998-02-19
KR910000622A (ko) 1991-01-29
EP0405116A2 (en) 1991-01-02
DK0405116T5 (da) 1996-04-29
JPH0672947A (ja) 1994-03-15
KR0148213B1 (en) 1998-08-17
GR3026351T3 (en) 1998-06-30
KR0148212B1 (en) 1998-08-17
EP0619296A1 (en) 1994-10-12
DE69030202D1 (de) 1997-04-17
GR3022801T3 (en) 1997-06-30
EP0405116B1 (en) 1995-12-06
EP0652208B1 (en) 1998-01-14
JPH0819040B2 (ja) 1996-02-28
CA2019335C (en) 2000-08-01
DK0619296T3 (da) 1997-05-05
EP0652208A1 (en) 1995-05-10
ATE131154T1 (de) 1995-12-15
ATE150006T1 (de) 1997-03-15
KR0143404B1 (ko) 1998-07-15
DE69030202T2 (de) 1997-07-10
CA2019335A1 (en) 1990-12-27
EP0619296B1 (en) 1997-03-12

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