ES2113861T3 - Nuevos derivados de lipido a y sus usos. - Google Patents
Nuevos derivados de lipido a y sus usos.Info
- Publication number
- ES2113861T3 ES2113861T3 ES90911354T ES90911354T ES2113861T3 ES 2113861 T3 ES2113861 T3 ES 2113861T3 ES 90911354 T ES90911354 T ES 90911354T ES 90911354 T ES90911354 T ES 90911354T ES 2113861 T3 ES2113861 T3 ES 2113861T3
- Authority
- ES
- Spain
- Prior art keywords
- lipid
- new derivatives
- derivatives
- rhodopsuedomonas
- dpla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002632 lipids Chemical class 0.000 title 1
- 239000002158 endotoxin Substances 0.000 abstract 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38383289A | 1989-07-21 | 1989-07-21 | |
| US07/467,449 US5041427A (en) | 1989-07-21 | 1990-01-19 | Lipid A derivatives |
| US07/522,446 US5158939A (en) | 1989-07-21 | 1990-05-11 | Method of stimulating the immune systems of animals and compositions useful therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2113861T3 true ES2113861T3 (es) | 1998-05-16 |
Family
ID=27409639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90911354T Expired - Lifetime ES2113861T3 (es) | 1989-07-21 | 1990-07-23 | Nuevos derivados de lipido a y sus usos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5158939A (https=) |
| EP (1) | EP0466838B1 (https=) |
| JP (1) | JPH04503363A (https=) |
| AT (1) | ATE164517T1 (https=) |
| AU (1) | AU6051790A (https=) |
| DE (1) | DE69032206T2 (https=) |
| DK (1) | DK0466838T3 (https=) |
| ES (1) | ES2113861T3 (https=) |
| WO (1) | WO1991001134A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9105992D0 (en) * | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| AU660325B2 (en) | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US7189834B2 (en) * | 1993-05-11 | 2007-03-13 | Marshall William E | Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection |
| US5840318A (en) * | 1993-05-11 | 1998-11-24 | Immunom Technologies, Inc. | Methods and compositions for modulating immune systems of animals |
| PT729473E (pt) * | 1993-11-17 | 2001-02-28 | Deutsche Om Arzneimittel Gmbh | Dissacaridos de glucosamina metodo para a sua preparacao composicao farmaceutica contendo os mesmos e sua utilizacao |
| US5679654A (en) * | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| US6368604B1 (en) * | 1997-09-26 | 2002-04-09 | University Of Maryland Biotechnology Institute | Non-pyrogenic derivatives of lipid A |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| US6649170B1 (en) * | 1999-05-12 | 2003-11-18 | Statens Serum Institut | Adjuvant combinations for immunization composition and vaccines |
| IL130087A0 (en) | 1999-05-24 | 2000-02-29 | Nova Measuring Instr Ltd | Optical inspection method and system |
| US6759241B1 (en) | 1999-10-04 | 2004-07-06 | University Of Maryland Biotechnology Institute | Adjuvant comprising a lipopolysaccharide antagonist |
| US6797279B2 (en) * | 2000-02-17 | 2004-09-28 | Biochem Industrial Co., Ltd. | Rhodopseudomonas capsulatas strain No. FERM BP-7434 for use in health foods |
| US7314732B2 (en) * | 2000-02-17 | 2008-01-01 | Tfk Inc. | Drug and manufacturing method of same |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| JP4347042B2 (ja) * | 2001-06-11 | 2009-10-21 | 協和発酵バイオ株式会社 | オリゴ糖結晶およびオリゴ糖結晶の製造方法 |
| AU2003243161A1 (en) * | 2002-04-24 | 2003-11-10 | The Regents Of The University Of California | Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses |
| KR100456681B1 (ko) * | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| CA2520865A1 (en) | 2003-03-31 | 2004-10-21 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
| EP1644408A1 (en) | 2003-07-15 | 2006-04-12 | Barros Research Institute | Eimeria tenella antigen for immunotherapy of coccidiosis |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| FR2862062B1 (fr) * | 2003-11-06 | 2005-12-23 | Oreal | Lipide a et composition topique, notamment cosmetique, le comprenant |
| WO2007092451A2 (en) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| PT2468300T (pt) | 2006-09-26 | 2018-01-30 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| US20180318414A1 (en) * | 2015-01-12 | 2018-11-08 | Children's Medical Center Corporation | Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 Antagonists |
| JP6918365B2 (ja) | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| WO2017090047A1 (en) | 2015-11-27 | 2017-06-01 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Glucosamine and derivatives thereof in imaging |
| EP3484441A4 (en) | 2016-07-15 | 2020-03-18 | President and Fellows of Harvard College | GLYCOLIPID COMPOSITIONS AND METHOD FOR USE |
| WO2024194686A2 (en) | 2023-03-17 | 2024-09-26 | Oxitope Pharma B.V. | Anti-phosphocholine antibodies and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987237A (en) * | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US4844894A (en) * | 1984-07-12 | 1989-07-04 | Ribi Immunochem Research Inc. | Method of inhibiting the onset of septicemia and endotoxemia |
| WO1986005687A1 (en) * | 1985-04-03 | 1986-10-09 | Wisconsin Alumni Research Foundation | Method of preventing diseases caused by gram-negative endotoxin in mammals |
| NL8601551A (nl) * | 1985-06-28 | 1987-01-16 | Sandoz Ag | Nieuwe saccharides, hun bereiding en farmaceutische samenstellingen, die hen bevatten. |
| US4746742A (en) * | 1985-11-28 | 1988-05-24 | Toho Yakuhin Kogyo Kabushiki Kaisha | Analogs of nonreducing monosaccharide moiety of lipid A |
-
1990
- 1990-05-11 US US07/522,446 patent/US5158939A/en not_active Expired - Fee Related
- 1990-07-23 AT AT90911354T patent/ATE164517T1/de not_active IP Right Cessation
- 1990-07-23 ES ES90911354T patent/ES2113861T3/es not_active Expired - Lifetime
- 1990-07-23 DE DE69032206T patent/DE69032206T2/de not_active Expired - Fee Related
- 1990-07-23 EP EP90911354A patent/EP0466838B1/en not_active Expired - Lifetime
- 1990-07-23 WO PCT/US1990/004145 patent/WO1991001134A1/en not_active Ceased
- 1990-07-23 JP JP90510616A patent/JPH04503363A/ja active Pending
- 1990-07-23 AU AU60517/90A patent/AU6051790A/en not_active Abandoned
- 1990-07-23 DK DK90911354.0T patent/DK0466838T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991001134A1 (en) | 1991-02-07 |
| AU6051790A (en) | 1991-02-22 |
| ATE164517T1 (de) | 1998-04-15 |
| DK0466838T3 (da) | 1998-04-27 |
| EP0466838A1 (en) | 1992-01-22 |
| US5158939A (en) | 1992-10-27 |
| EP0466838A4 (https=) | 1995-02-22 |
| DE69032206D1 (de) | 1998-05-07 |
| JPH04503363A (ja) | 1992-06-18 |
| EP0466838B1 (en) | 1998-04-01 |
| DE69032206T2 (de) | 1998-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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