ATE164517T1 - Lipid-a-derivate sowie deren verwendungen - Google Patents
Lipid-a-derivate sowie deren verwendungenInfo
- Publication number
- ATE164517T1 ATE164517T1 AT90911354T AT90911354T ATE164517T1 AT E164517 T1 ATE164517 T1 AT E164517T1 AT 90911354 T AT90911354 T AT 90911354T AT 90911354 T AT90911354 T AT 90911354T AT E164517 T1 ATE164517 T1 AT E164517T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- derivatives
- rhodopsuedomonas
- dpla
- lipopolysaccharide
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title 1
- 239000002158 endotoxin Substances 0.000 abstract 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38383289A | 1989-07-21 | 1989-07-21 | |
| US07/467,449 US5041427A (en) | 1989-07-21 | 1990-01-19 | Lipid A derivatives |
| US07/522,446 US5158939A (en) | 1989-07-21 | 1990-05-11 | Method of stimulating the immune systems of animals and compositions useful therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164517T1 true ATE164517T1 (de) | 1998-04-15 |
Family
ID=27409639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90911354T ATE164517T1 (de) | 1989-07-21 | 1990-07-23 | Lipid-a-derivate sowie deren verwendungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5158939A (https=) |
| EP (1) | EP0466838B1 (https=) |
| JP (1) | JPH04503363A (https=) |
| AT (1) | ATE164517T1 (https=) |
| AU (1) | AU6051790A (https=) |
| DE (1) | DE69032206T2 (https=) |
| DK (1) | DK0466838T3 (https=) |
| ES (1) | ES2113861T3 (https=) |
| WO (1) | WO1991001134A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9105992D0 (en) * | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| US7189834B2 (en) * | 1993-05-11 | 2007-03-13 | Marshall William E | Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection |
| US5840318A (en) * | 1993-05-11 | 1998-11-24 | Immunom Technologies, Inc. | Methods and compositions for modulating immune systems of animals |
| PL181241B1 (pl) * | 1993-11-17 | 2001-06-29 | Deutsche Om Arzneimittel Gmbh | Disacharydy beta(1 6)glukozoaminowe, sposób wytwarzania disacharydu beta(1 6) glukozoaminowego, zawierająca je kompozycja farmaceutyczna i środek immunomodulujący i/lub przeciwnowotworowy oraz szczepionka |
| US5679654A (en) * | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| US6368604B1 (en) | 1997-09-26 | 2002-04-09 | University Of Maryland Biotechnology Institute | Non-pyrogenic derivatives of lipid A |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| US6649170B1 (en) * | 1999-05-12 | 2003-11-18 | Statens Serum Institut | Adjuvant combinations for immunization composition and vaccines |
| IL130087A0 (en) | 1999-05-24 | 2000-02-29 | Nova Measuring Instr Ltd | Optical inspection method and system |
| WO2001025254A2 (en) | 1999-10-04 | 2001-04-12 | University Of Maryland Biotechnology Institute | Novel adjuvant comprising a lipopolysaccharide antagonist |
| BR0104543A (pt) * | 2000-02-17 | 2002-01-08 | Biochem Ind Co Ltd | Bactéria fotossintética vermelha e alimento saudável |
| US7314732B2 (en) * | 2000-02-17 | 2008-01-01 | Tfk Inc. | Drug and manufacturing method of same |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| CN100509830C (zh) * | 2001-06-11 | 2009-07-08 | 协和发酵工业株式会社 | 寡糖结晶及寡糖结晶的制造方法 |
| WO2003090685A2 (en) * | 2002-04-24 | 2003-11-06 | The Regents Of The University Of California | Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses |
| KR100456681B1 (ko) * | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| WO2004089407A2 (en) | 2003-03-31 | 2004-10-21 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
| US7393534B2 (en) | 2003-07-15 | 2008-07-01 | Barros Research Institute | Compositions and methods for immunotherapy of cancer and infectious diseases |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| FR2862062B1 (fr) * | 2003-11-06 | 2005-12-23 | Oreal | Lipide a et composition topique, notamment cosmetique, le comprenant |
| US8206726B2 (en) | 2006-02-06 | 2012-06-26 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| PL2068918T5 (pl) * | 2006-09-26 | 2024-12-02 | Access To Advanced Health Institute | Kompozycja szczepionki zawierająca syntetyczny adiuwant |
| US9539281B2 (en) | 2011-07-12 | 2017-01-10 | The Brigham And Women's Hospital, Inc. | Lipid-containing PSA compositions, methods of isolation and methods of use thereof |
| JP2018501322A (ja) | 2015-01-12 | 2018-01-18 | チルドレンズ メディカル センター コーポレーション | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP6918365B2 (ja) | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| US10905783B2 (en) | 2015-11-27 | 2021-02-02 | Michal RIVLIN | Glucosamine and derivatives thereof in imaging |
| US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| KR20250173600A (ko) | 2023-03-17 | 2025-12-10 | 옥시토프 파마 비.브이. | 항-포스포콜린 항체 및 그 사용 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987237A (en) * | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| US4844894A (en) * | 1984-07-12 | 1989-07-04 | Ribi Immunochem Research Inc. | Method of inhibiting the onset of septicemia and endotoxemia |
| WO1986005687A1 (en) * | 1985-04-03 | 1986-10-09 | Wisconsin Alumni Research Foundation | Method of preventing diseases caused by gram-negative endotoxin in mammals |
| HU199494B (en) * | 1985-06-28 | 1990-02-28 | Sandoz Ag | Process for producing new saccharides and pharmaceutical compositions comprising same |
| US4746742A (en) * | 1985-11-28 | 1988-05-24 | Toho Yakuhin Kogyo Kabushiki Kaisha | Analogs of nonreducing monosaccharide moiety of lipid A |
-
1990
- 1990-05-11 US US07/522,446 patent/US5158939A/en not_active Expired - Fee Related
- 1990-07-23 WO PCT/US1990/004145 patent/WO1991001134A1/en not_active Ceased
- 1990-07-23 JP JP90510616A patent/JPH04503363A/ja active Pending
- 1990-07-23 AT AT90911354T patent/ATE164517T1/de not_active IP Right Cessation
- 1990-07-23 ES ES90911354T patent/ES2113861T3/es not_active Expired - Lifetime
- 1990-07-23 DK DK90911354.0T patent/DK0466838T3/da active
- 1990-07-23 EP EP90911354A patent/EP0466838B1/en not_active Expired - Lifetime
- 1990-07-23 AU AU60517/90A patent/AU6051790A/en not_active Abandoned
- 1990-07-23 DE DE69032206T patent/DE69032206T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2113861T3 (es) | 1998-05-16 |
| AU6051790A (en) | 1991-02-22 |
| WO1991001134A1 (en) | 1991-02-07 |
| DE69032206T2 (de) | 1998-07-23 |
| EP0466838A4 (https=) | 1995-02-22 |
| EP0466838B1 (en) | 1998-04-01 |
| JPH04503363A (ja) | 1992-06-18 |
| EP0466838A1 (en) | 1992-01-22 |
| US5158939A (en) | 1992-10-27 |
| DK0466838T3 (da) | 1998-04-27 |
| DE69032206D1 (de) | 1998-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee | ||
| UEP | Publication of translation of european patent specification |