AU6051790A - Novel lipid a derivatives and uses therefor - Google Patents

Novel lipid a derivatives and uses therefor

Info

Publication number
AU6051790A
AU6051790A AU60517/90A AU6051790A AU6051790A AU 6051790 A AU6051790 A AU 6051790A AU 60517/90 A AU60517/90 A AU 60517/90A AU 6051790 A AU6051790 A AU 6051790A AU 6051790 A AU6051790 A AU 6051790A
Authority
AU
Australia
Prior art keywords
derivatives
uses therefor
novel lipid
lipid
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU60517/90A
Other languages
English (en)
Inventor
Nilofer Oureshi
Kuni K. Takayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/467,449 external-priority patent/US5041427A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU6051790A publication Critical patent/AU6051790A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU60517/90A 1989-07-21 1990-07-23 Novel lipid a derivatives and uses therefor Abandoned AU6051790A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38383289A 1989-07-21 1989-07-21
US383832 1989-07-21
US467449 1990-01-19
US07/467,449 US5041427A (en) 1989-07-21 1990-01-19 Lipid A derivatives
US522446 1990-05-11
US07/522,446 US5158939A (en) 1989-07-21 1990-05-11 Method of stimulating the immune systems of animals and compositions useful therefor

Publications (1)

Publication Number Publication Date
AU6051790A true AU6051790A (en) 1991-02-22

Family

ID=27409639

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60517/90A Abandoned AU6051790A (en) 1989-07-21 1990-07-23 Novel lipid a derivatives and uses therefor

Country Status (9)

Country Link
US (1) US5158939A (https=)
EP (1) EP0466838B1 (https=)
JP (1) JPH04503363A (https=)
AT (1) ATE164517T1 (https=)
AU (1) AU6051790A (https=)
DE (1) DE69032206T2 (https=)
DK (1) DK0466838T3 (https=)
ES (1) ES2113861T3 (https=)
WO (1) WO1991001134A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9105992D0 (en) * 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
US5530113A (en) * 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
US7189834B2 (en) * 1993-05-11 2007-03-13 Marshall William E Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
US5840318A (en) * 1993-05-11 1998-11-24 Immunom Technologies, Inc. Methods and compositions for modulating immune systems of animals
PL181241B1 (pl) * 1993-11-17 2001-06-29 Deutsche Om Arzneimittel Gmbh Disacharydy beta(1 6)glukozoaminowe, sposób wytwarzania disacharydu beta(1 6) glukozoaminowego, zawierająca je kompozycja farmaceutyczna i środek immunomodulujący i/lub przeciwnowotworowy oraz szczepionka
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5681824A (en) * 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6649170B1 (en) * 1999-05-12 2003-11-18 Statens Serum Institut Adjuvant combinations for immunization composition and vaccines
IL130087A0 (en) 1999-05-24 2000-02-29 Nova Measuring Instr Ltd Optical inspection method and system
WO2001025254A2 (en) 1999-10-04 2001-04-12 University Of Maryland Biotechnology Institute Novel adjuvant comprising a lipopolysaccharide antagonist
BR0104543A (pt) * 2000-02-17 2002-01-08 Biochem Ind Co Ltd Bactéria fotossintética vermelha e alimento saudável
US7314732B2 (en) * 2000-02-17 2008-01-01 Tfk Inc. Drug and manufacturing method of same
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
CN100509830C (zh) * 2001-06-11 2009-07-08 协和发酵工业株式会社 寡糖结晶及寡糖结晶的制造方法
WO2003090685A2 (en) * 2002-04-24 2003-11-06 The Regents Of The University Of California Methods for stimulating tlr/irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses
KR100456681B1 (ko) * 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
WO2004089407A2 (en) 2003-03-31 2004-10-21 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US7393534B2 (en) 2003-07-15 2008-07-01 Barros Research Institute Compositions and methods for immunotherapy of cancer and infectious diseases
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
FR2862062B1 (fr) * 2003-11-06 2005-12-23 Oreal Lipide a et composition topique, notamment cosmetique, le comprenant
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
PL2068918T5 (pl) * 2006-09-26 2024-12-02 Access To Advanced Health Institute Kompozycja szczepionki zawierająca syntetyczny adiuwant
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
JP2018501322A (ja) 2015-01-12 2018-01-18 チルドレンズ メディカル センター コーポレーション トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能
JP6918365B2 (ja) 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化ｐｓａ組成物および方法
US10905783B2 (en) 2015-11-27 2021-02-02 Michal RIVLIN Glucosamine and derivatives thereof in imaging
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
KR20250173600A (ko) 2023-03-17 2025-12-10 옥시토프 파마 비.브이. 항-포스포콜린 항체 및 그 사용 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987237A (en) * 1983-08-26 1991-01-22 Ribi Immunochem Research, Inc. Derivatives of monophosphoryl lipid A
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
WO1986005687A1 (en) * 1985-04-03 1986-10-09 Wisconsin Alumni Research Foundation Method of preventing diseases caused by gram-negative endotoxin in mammals
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
US4746742A (en) * 1985-11-28 1988-05-24 Toho Yakuhin Kogyo Kabushiki Kaisha Analogs of nonreducing monosaccharide moiety of lipid A

Also Published As

Publication number Publication date
ES2113861T3 (es) 1998-05-16
WO1991001134A1 (en) 1991-02-07
DE69032206T2 (de) 1998-07-23
EP0466838A4 (https=) 1995-02-22
EP0466838B1 (en) 1998-04-01
JPH04503363A (ja) 1992-06-18
EP0466838A1 (en) 1992-01-22
US5158939A (en) 1992-10-27
ATE164517T1 (de) 1998-04-15
DK0466838T3 (da) 1998-04-27
DE69032206D1 (de) 1998-05-07

Similar Documents

Publication Publication Date Title
AU6051790A (en) Novel lipid a derivatives and uses therefor
US5051835B1 (en) Method of processing theatrical film
AU583371B2 (en) Method for producing an aqueous silicone emulsion composition
WO1991003248A3 (en) Method for immune system activation
AU8280287A (en) Lighting apparatus and method
AU1618288A (en) Ligament attachment method and apparatus
AU2148888A (en) A process for the preparation of an antioxydant extract of spices
AU6912787A (en) Method and tool for inserting an intraocular lens
AU5300190A (en) Poultry processing apparatus and method
EP0126313A3 (en) Use of diterpene derivatives of forskolin for immune stimulation
AU3863489A (en) Method of preparing sphingosine derivatives and an aldehyde used therein
PL311036A1 (en) Method of obtaining an anticarcinogenic vaccine
GB2235060B (en) Method of identifying characterisitics of light output by a light source
AU6251790A (en) Focused light source and method
AU587530B2 (en) Method of spin-welding
AU4266389A (en) Aqueous dispersion of an alkenyloxysilane-based silicone
EP0383943A4 (en) Light emitting device and method of producing the same
AU3822589A (en) Method and apparatus for the assembly of friction components
PH27473A (en) Method of producing wing nuts
IL75357A0 (en) Primycin components and process for the separation of the antibiotic complex
AU582303B2 (en) Method of curve approximation
EP0424547A4 (en) Method of producing ferrocenoyl derivative
EP0189841A3 (en) Enzymatic detection of bacterial capsular polysaccharide antigens
AU8732291A (en) Method for enzymatic determination of aldoses
AU5219090A (en) Microorganism capable of producing l-lysine and method for producing l-lysine thereby