ES2109529T3 - Procedimiento para la preparacion de derivados de vitamina d3 y sus intermedios. - Google Patents

Procedimiento para la preparacion de derivados de vitamina d3 y sus intermedios.

Info

Publication number
ES2109529T3
ES2109529T3 ES94103360T ES94103360T ES2109529T3 ES 2109529 T3 ES2109529 T3 ES 2109529T3 ES 94103360 T ES94103360 T ES 94103360T ES 94103360 T ES94103360 T ES 94103360T ES 2109529 T3 ES2109529 T3 ES 2109529T3
Authority
ES
Spain
Prior art keywords
intermediates
vitamin
derivatives
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94103360T
Other languages
English (en)
Inventor
Okabe Masami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2109529T3 publication Critical patent/ES2109529T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PREPARAR 1 ,25(R),26-TRIHIDROXI-22EENO-COLECALCIFEROL Y 1 -25(S),26-TRIHIDROXI-22E-ENO-COLECALCIFEROL POR MEDIO DE LOS CORRESPONDIENTES ISOMEROS 5E, 7E.
ES94103360T 1993-03-18 1994-03-05 Procedimiento para la preparacion de derivados de vitamina d3 y sus intermedios. Expired - Lifetime ES2109529T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,905 US5300705A (en) 1993-03-18 1993-03-18 Process for the preparation of 1α,25,26-trihydroxy-22-ene-cholecalciferol

Publications (1)

Publication Number Publication Date
ES2109529T3 true ES2109529T3 (es) 1998-01-16

Family

ID=21867498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94103360T Expired - Lifetime ES2109529T3 (es) 1993-03-18 1994-03-05 Procedimiento para la preparacion de derivados de vitamina d3 y sus intermedios.

Country Status (8)

Country Link
US (1) US5300705A (es)
EP (1) EP0617015B1 (es)
JP (1) JPH072713A (es)
CN (1) CN1040430C (es)
AT (1) ATE159716T1 (es)
DE (1) DE69406485T2 (es)
DK (1) DK0617015T3 (es)
ES (1) ES2109529T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103122009B (zh) * 2013-01-09 2015-11-25 江苏吉贝尔药业股份有限公司 两种用于合成他卡西醇支链的重要中间体化合物
CN103012463B (zh) * 2013-01-17 2016-02-10 南京理工大学 (s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110958A (en) * 1984-02-08 1992-05-05 Hoffmann-La Roche Inc. Compounds, process and intermediates
US5120722A (en) * 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
DK157244C (da) * 1984-02-08 1990-04-23 Hoffmann La Roche Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse
US4755329A (en) * 1985-06-10 1988-07-05 Wisconsin Alumni Research Foundation Process and intermediates for preparing 1α-hydroxyvitamin D compounds
US5225579A (en) * 1988-03-16 1993-07-06 Hoxan Corporation Method of manufacturing vitamin D2, Vitamin D3, activated type vitamin D2, activated type vitamin D3, and their derivatives

Also Published As

Publication number Publication date
CN1096291A (zh) 1994-12-14
US5300705A (en) 1994-04-05
DE69406485T2 (de) 1998-05-28
EP0617015B1 (en) 1997-10-29
DE69406485D1 (de) 1997-12-04
DK0617015T3 (da) 1998-03-09
EP0617015A2 (en) 1994-09-28
CN1040430C (zh) 1998-10-28
ATE159716T1 (de) 1997-11-15
EP0617015A3 (en) 1995-08-16
JPH072713A (ja) 1995-01-06

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