DK0617015T3 - Fremgangsmåde til fremstilling af vitamin-D3-derivater og mellemprodukter dertil - Google Patents
Fremgangsmåde til fremstilling af vitamin-D3-derivater og mellemprodukter dertilInfo
- Publication number
- DK0617015T3 DK0617015T3 DK94103360.7T DK94103360T DK0617015T3 DK 0617015 T3 DK0617015 T3 DK 0617015T3 DK 94103360 T DK94103360 T DK 94103360T DK 0617015 T3 DK0617015 T3 DK 0617015T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- give
- cpd
- specific
- reacting
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/032,905 US5300705A (en) | 1993-03-18 | 1993-03-18 | Process for the preparation of 1α,25,26-trihydroxy-22-ene-cholecalciferol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0617015T3 true DK0617015T3 (da) | 1998-03-09 |
Family
ID=21867498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94103360.7T DK0617015T3 (da) | 1993-03-18 | 1994-03-05 | Fremgangsmåde til fremstilling af vitamin-D3-derivater og mellemprodukter dertil |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5300705A (da) |
| EP (1) | EP0617015B1 (da) |
| JP (1) | JPH072713A (da) |
| CN (1) | CN1040430C (da) |
| AT (1) | ATE159716T1 (da) |
| DE (1) | DE69406485T2 (da) |
| DK (1) | DK0617015T3 (da) |
| ES (1) | ES2109529T3 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103122009B (zh) * | 2013-01-09 | 2015-11-25 | 江苏吉贝尔药业股份有限公司 | 两种用于合成他卡西醇支链的重要中间体化合物 |
| CN103012463B (zh) * | 2013-01-17 | 2016-02-10 | 南京理工大学 | (s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0154185B1 (en) * | 1984-02-08 | 1988-10-05 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Calciferol derivatives |
| US5120722A (en) * | 1984-02-08 | 1992-06-09 | Hoffmann-La Roche Inc. | Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia |
| US5110958A (en) * | 1984-02-08 | 1992-05-05 | Hoffmann-La Roche Inc. | Compounds, process and intermediates |
| US4755329A (en) * | 1985-06-10 | 1988-07-05 | Wisconsin Alumni Research Foundation | Process and intermediates for preparing 1α-hydroxyvitamin D compounds |
| US5225579A (en) * | 1988-03-16 | 1993-07-06 | Hoxan Corporation | Method of manufacturing vitamin D2, Vitamin D3, activated type vitamin D2, activated type vitamin D3, and their derivatives |
-
1993
- 1993-03-18 US US08/032,905 patent/US5300705A/en not_active Expired - Fee Related
-
1994
- 1994-03-05 ES ES94103360T patent/ES2109529T3/es not_active Expired - Lifetime
- 1994-03-05 EP EP94103360A patent/EP0617015B1/en not_active Expired - Lifetime
- 1994-03-05 AT AT94103360T patent/ATE159716T1/de not_active IP Right Cessation
- 1994-03-05 DK DK94103360.7T patent/DK0617015T3/da active
- 1994-03-05 DE DE69406485T patent/DE69406485T2/de not_active Expired - Fee Related
- 1994-03-16 JP JP6070169A patent/JPH072713A/ja active Pending
- 1994-03-17 CN CN94103147A patent/CN1040430C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2109529T3 (es) | 1998-01-16 |
| CN1096291A (zh) | 1994-12-14 |
| ATE159716T1 (de) | 1997-11-15 |
| US5300705A (en) | 1994-04-05 |
| JPH072713A (ja) | 1995-01-06 |
| DE69406485D1 (de) | 1997-12-04 |
| EP0617015A3 (en) | 1995-08-16 |
| EP0617015B1 (en) | 1997-10-29 |
| DE69406485T2 (de) | 1998-05-28 |
| CN1040430C (zh) | 1998-10-28 |
| EP0617015A2 (en) | 1994-09-28 |
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