ES2109177A1 - Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo. - Google Patents

Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo.

Info

Publication number
ES2109177A1
ES2109177A1 ES09502023A ES9502023A ES2109177A1 ES 2109177 A1 ES2109177 A1 ES 2109177A1 ES 09502023 A ES09502023 A ES 09502023A ES 9502023 A ES9502023 A ES 9502023A ES 2109177 A1 ES2109177 A1 ES 2109177A1
Authority
ES
Spain
Prior art keywords
group
protected
phosphate
protecting groups
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09502023A
Other languages
English (en)
Other versions
ES2109177B1 (es
Inventor
Muller Enrique Pedroso
Sagarra Ana Grandas
El Mostafa Alazzouzi
Sanchez Nuria Escaja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat Autonoma de Barcelona UAB
Universitat de Barcelona UB
Original Assignee
Universitat Autonoma de Barcelona UAB
Universitat de Barcelona UB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat Autonoma de Barcelona UAB, Universitat de Barcelona UB filed Critical Universitat Autonoma de Barcelona UAB
Priority to ES09502023A priority Critical patent/ES2109177B1/es
Priority to US08/731,202 priority patent/US6153742A/en
Publication of ES2109177A1 publication Critical patent/ES2109177A1/es
Application granted granted Critical
Publication of ES2109177B1 publication Critical patent/ES2109177B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PROCEDIMIENTO GENERAL DE PREPARACION DE OLIGONUCLEOTIDOS CICLICOS E INTERMEDIOS PARA EL MISMO. SE PARTE DE UN NUCLEOTIDO PROTEGIDO Y ANCLADO A TRAVES DEL GRUPO FOSFATO; T Y U NO ESTAN PROTEGIDAS; A Y C ESTAN PROTEGIDAS POR BENZOILO, Y G ESTA PROTEGIDA POR ISOBUTIRILO; EL HIDROXILO-5" ESTA PROTEGIDO POR R3; EL FOSFATO 3''-TERMINAL ESTA PROTEGIDO POR R2 Y POR UN GRUPO PROTECTOR/ANCLADOR X-(P''). SE REALIZA LA ELONGACION CON EL FOSFATO 3''-TERMINAL PROTEGIDO CON R2 Y YA DESPROTEGIDO, Y SE PROTEGEN LOS FOSFATOS DE CADENA MEDIANTE R1; DE MODO QUE R2 Y R3 PUEDAN SEPARARSE EN CONDICIONES QUE DEJEN INTACTOS A R1, A X-(P'') Y A LOS GRUPOS PROTECTORES DE A, C Y G. SE SEPARAN LOS R2 (SI NO SE HAN ELIMINADO PREVIAMENTE) Y R3, Y SE CICLA. EN EL INTERMEDIO CICLICO OBTENIDO SE SEPARAN LOS GRUPOS PROTECTORES R1; SE DESANCLA DEL SOPORTE POLIMERICO, Y SE SEPARAN LOS GRUPOS PROTECTORES DE A, C Y G. LOS PRODUCTOS OBTENIDOS TIENEN USO POTENCIAL COMO OLIGONUCLEOTIDOS ANTISENTIDO Y COMO SONDAS, TANTO EN TERAPEUTICA COMO EN DIAGNOSIS.
ES09502023A 1995-10-11 1995-10-11 Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo. Expired - Fee Related ES2109177B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES09502023A ES2109177B1 (es) 1995-10-11 1995-10-11 Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo.
US08/731,202 US6153742A (en) 1995-10-11 1996-10-10 General process for the preparation of cyclic oligonucleotides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09502023A ES2109177B1 (es) 1995-10-11 1995-10-11 Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo.

Publications (2)

Publication Number Publication Date
ES2109177A1 true ES2109177A1 (es) 1998-01-01
ES2109177B1 ES2109177B1 (es) 1998-07-16

Family

ID=8291888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09502023A Expired - Fee Related ES2109177B1 (es) 1995-10-11 1995-10-11 Procedimiento general de preparacion de oligonucleotidos ciclicos e intermedios para el mismo.

Country Status (2)

Country Link
US (1) US6153742A (es)
ES (1) ES2109177B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11787833B2 (en) 2019-05-09 2023-10-17 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as sting modulators

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023049275A2 (en) * 2021-09-23 2023-03-30 Arnay Sciences, Llc Cyclic structured oligonucleotides as therapeutic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017484A1 (en) * 1991-03-27 1992-10-15 Research Corporation Technologies, Inc. Single-stranded circular oligonucleotides
FR2675803B1 (fr) * 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARBATO, S. et al. "A Polymer-Nucleotide Linkage Useful for the Solid Phase Synthesis of Cyclic Oligodeoxyribonucleotides." TETRAHEDRON. 1989. Vol. 45, n‘ 14, pßginas 4523-4536 *
DE NAPOLI, L. et al. "Facile Preparation of Cyclic Oligoribonucleotides." J. CHEM. SOC., PERKIN TRANS. I. 1993. (7), pßginas 747-749 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11787833B2 (en) 2019-05-09 2023-10-17 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as sting modulators

Also Published As

Publication number Publication date
US6153742A (en) 2000-11-28
ES2109177B1 (es) 1998-07-16

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