ES2108882T3 - Procedimiento para la alquilacion de derivados de estrona. - Google Patents

Procedimiento para la alquilacion de derivados de estrona.

Info

Publication number
ES2108882T3
ES2108882T3 ES93923513T ES93923513T ES2108882T3 ES 2108882 T3 ES2108882 T3 ES 2108882T3 ES 93923513 T ES93923513 T ES 93923513T ES 93923513 T ES93923513 T ES 93923513T ES 2108882 T3 ES2108882 T3 ES 2108882T3
Authority
ES
Spain
Prior art keywords
pct
derivatives
date
estrona
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923513T
Other languages
English (en)
Inventor
Carsten Seilz
Dieter Hubl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2108882T3 publication Critical patent/ES2108882T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA ALQUILACION DE DERIVADOS DE ESTRONA, QUE SE CARACTERIZA PORQUE, SE ELABORA UNA SUSPENSION DE UN DERIVADO DE ESTRONA EN DIMETILFORMAMIDA Y DIESTER DE ACIDO CARBONICO Y GUANIDINA Y/O UNA ALQUIL GUANIDINA SE DISUELVEN EN LA SUSPENSION Y LA MEZCLA SUSTANCIALMENTE LIBRE DE OXIGENO SE DEJA REACCIONAR A 100-200 ON DE REACCION RESULTANTE.
ES93923513T 1992-10-22 1993-10-21 Procedimiento para la alquilacion de derivados de estrona. Expired - Lifetime ES2108882T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4235657A DE4235657A1 (de) 1992-10-22 1992-10-22 Verfahren zum Alkylieren von Östronderivaten

Publications (1)

Publication Number Publication Date
ES2108882T3 true ES2108882T3 (es) 1998-01-01

Family

ID=6471086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923513T Expired - Lifetime ES2108882T3 (es) 1992-10-22 1993-10-21 Procedimiento para la alquilacion de derivados de estrona.

Country Status (10)

Country Link
US (1) US5621124A (es)
EP (1) EP0665849B1 (es)
JP (1) JPH09505800A (es)
AT (1) ATE157371T1 (es)
CA (1) CA2147374A1 (es)
DE (2) DE4235657A1 (es)
DK (1) DK0665849T3 (es)
ES (1) ES2108882T3 (es)
GR (1) GR3025240T3 (es)
WO (1) WO1994009024A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
US6908910B2 (en) * 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US5778448A (en) * 1997-05-12 1998-07-14 Maher; Thomas Henry Assembly for attaching sunglasses to a cap
US20020002294A1 (en) * 1997-09-24 2002-01-03 D' Amato Robert J. Estrogenic compounds as antiangiogenic agents
EP1124545B1 (en) 1998-08-11 2004-12-15 EntreMed, Inc. Use of 2-methoxyestradiol as anti-fungal agents
US7087592B1 (en) * 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
US6995278B2 (en) * 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
US20050192258A1 (en) * 2000-08-18 2005-09-01 Agoston Gregory E. Antiangiogenic agents
WO2003063791A2 (en) * 2002-01-30 2003-08-07 Entremed, Inc. Non-steroidal analogs of 2-methoxyestradiol
EP1633367A2 (en) * 2003-05-28 2006-03-15 EntreMed, Inc. Antiangiogenic agents
US20070004689A1 (en) * 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
CA2558014A1 (en) * 2004-03-12 2005-09-29 Entremed, Inc. Antiangiogenic agents
CA2587448A1 (en) * 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
US20070176403A1 (en) * 2006-02-01 2007-08-02 Dennis Calderone Air adjustable seat
US8399440B2 (en) * 2006-03-20 2013-03-19 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
WO2008094665A1 (en) * 2007-01-31 2008-08-07 Entremed, Inc. Method of treating amyloidosis mediated diseases

Also Published As

Publication number Publication date
US5621124A (en) 1997-04-15
EP0665849B1 (de) 1997-08-27
DE4235657A1 (de) 1994-06-23
CA2147374A1 (en) 1994-04-28
ATE157371T1 (de) 1997-09-15
EP0665849A1 (de) 1995-08-09
JPH09505800A (ja) 1997-06-10
DE59307221D1 (de) 1997-10-02
GR3025240T3 (en) 1998-02-27
DK0665849T3 (da) 1998-04-06
WO1994009024A1 (de) 1994-04-28

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