ES2107444T3 - Nuevos aminofosfina-fosfinitos, su procedimiento de fabricacion y su aplicacion a reacciones enantioselectivas. - Google Patents

Nuevos aminofosfina-fosfinitos, su procedimiento de fabricacion y su aplicacion a reacciones enantioselectivas.

Info

Publication number
ES2107444T3
ES2107444T3 ES91400401T ES91400401T ES2107444T3 ES 2107444 T3 ES2107444 T3 ES 2107444T3 ES 91400401 T ES91400401 T ES 91400401T ES 91400401 T ES91400401 T ES 91400401T ES 2107444 T3 ES2107444 T3 ES 2107444T3
Authority
ES
Spain
Prior art keywords
application
enantious
aminophosphine
phosphinites
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91400401T
Other languages
English (en)
Inventor
Corinne Hatat
Alain Roucoux
Andre Mortreux
Francis Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2107444T3 publication Critical patent/ES2107444T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2495—Ligands comprising a phosphine-P atom and one or more further complexing phosphorus atoms covered by groups B01J31/1845 - B01J31/1885, e.g. phosphine/phosphinate or phospholyl/phosphonate ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/49—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide
    • C07C45/50—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
    • C07C45/505—Asymmetric hydroformylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/46—Phosphinous acids [R2POH], [R2P(= O)H]: Thiophosphinous acids including[R2PSH]; [R2P(=S)H]; Aminophosphines [R2PNH2]; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/32—Addition reactions to C=C or C-C triple bonds
    • B01J2231/321—Hydroformylation, metalformylation, carbonylation or hydroaminomethylation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/32—Addition reactions to C=C or C-C triple bonds
    • B01J2231/324—Cyclisations via conversion of C-C multiple to single or less multiple bonds, e.g. cycloadditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0239—Quaternary ammonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LIGANDOS FOSFORADOS QUIRALES DE LAS FORMULAS: R Y R'' EN (II), DIFERENTES EL UNO DEL OTRO, SON RADICALES HIDROCARBONADOS (ALQUILO, CICLOALQUILO, ARILO, ARALQUILO O ALCARILO); R ES (III) ES UN RADICAL HIDROCARBONADO (ALQUILO, CICLOALQUILO O ARILO); R (AL CUADRADO) = H O RADICAL HIDROCARBONADO, EVENTUALMENTE PORTADOR DE UNA FUNCION CO EN (II), Y PORTADOR DE UNA FUNCION CO EN (III); R ELEVADO 3 Y R ELEVADO 4, NECESARIAMENTE DIFERENTES,SALVO SI R ELEVADO 5 Y R ELEVADO 6 SON DIFERENTES , = H, RADICAL HIDROCARBONADO EVENTUALMENTE FUNCIONALIZADO; R ELEVADO 5 Y R ELEVADO 6 = H O RADICAL HIDROCARBONADO EVENTUALMENTE FUNCIONALIZADO; (UNO DE ENTRE R ELEVADO 3 Y R ELEVADO 4 PUEDE LLEVAR UNA FUNCION -OPR SUB 2 O -NPR'' SUB 2 -NPR SUB 2); R (AL CUADRADO) Y R ELEVADO 3 Y LOS N Y C QUE LOS LLEVAN RESPECTIVAMENTE PUEDEN FORMAR JUNTOS UN HETEROCICLO; O BIEN R (AL CUADRADO) Y R ELEVADO 5, LOS N Y C QUE LOS LLEVAN RESPECTIVAMENTE Y EL C INTERMEDIO PUEDEN FORMAR JUNTOS UN HETEROCICLO. APLICACION EN UNA REACCION ENANTIOSELECTIVA (HIDROGENACION DE COMPUESTOS CARBONILADOS POR EJEMPLO).
ES91400401T 1990-02-19 1991-02-15 Nuevos aminofosfina-fosfinitos, su procedimiento de fabricacion y su aplicacion a reacciones enantioselectivas. Expired - Lifetime ES2107444T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9001976A FR2658515A1 (fr) 1990-02-19 1990-02-19 Nouveaux aminophosphine-phosphinites, leur procede de fabrication et leur application a des reactions enantioselectives.

Publications (1)

Publication Number Publication Date
ES2107444T3 true ES2107444T3 (es) 1997-12-01

Family

ID=9393874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91400401T Expired - Lifetime ES2107444T3 (es) 1990-02-19 1991-02-15 Nuevos aminofosfina-fosfinitos, su procedimiento de fabricacion y su aplicacion a reacciones enantioselectivas.

Country Status (9)

Country Link
EP (1) EP0443923B1 (es)
JP (1) JPH0778070B2 (es)
AT (1) ATE157367T1 (es)
CA (1) CA2036559A1 (es)
DE (1) DE69127386T2 (es)
DK (1) DK0443923T3 (es)
ES (1) ES2107444T3 (es)
FR (1) FR2658515A1 (es)
GR (1) GR3025043T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475146A (en) * 1993-09-02 1995-12-12 E. I. Du Pont De Nemours And Company Enantioselective hydroformylation
US5481006A (en) * 1994-01-11 1996-01-02 E. I. Du Pont De Nemours And Company Selective asymmetric hydrogenation of dehydroamino acid derivatives using rhodium and iridium diphosphinite carbohydrate catalyst compositions
FR2753193B1 (fr) * 1996-09-11 1998-12-04 Sanofi Sa Procede de preparation de benzylalcools alpha-substitues optiquement actifs
EP0864576A1 (de) 1997-03-10 1998-09-16 F. Hoffmann-La Roche Ag Neue Amidophosphin-Phosphinit-Verbindungen
WO2019180084A1 (en) * 2018-03-20 2019-09-26 Université de Bourgogne C-bulky p-chirogenic organophosphorus compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550201B1 (fr) * 1983-08-05 1986-02-28 Charbonnages Ste Chimique Ligands phosphores chiraux, leur procede de fabrication a partir d'aminoacides naturels et leur application a la catalyse de reactions de synthese enantioselective
FR2600330B1 (fr) * 1986-06-23 1988-12-16 Charbonnages Ste Chimique Procede d'hydrogenation asymetrique de composes carbonyles et composes obtenus
DD253995A1 (de) * 1986-11-28 1988-02-10 Akad Wissenschaften Ddr Verfahren zur herstellung von (r)- und (s)-phenyl-alanin und dessen derivaten

Also Published As

Publication number Publication date
DK0443923T3 (da) 1998-04-06
JPH06122690A (ja) 1994-05-06
CA2036559A1 (fr) 1991-08-20
JPH0778070B2 (ja) 1995-08-23
GR3025043T3 (en) 1998-01-30
DE69127386D1 (de) 1997-10-02
DE69127386T2 (de) 1998-04-02
FR2658515A1 (fr) 1991-08-23
EP0443923A1 (fr) 1991-08-28
ATE157367T1 (de) 1997-09-15
EP0443923B1 (fr) 1997-08-27

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