ES2106772T3 - Variantes de pai-2. - Google Patents
Variantes de pai-2.Info
- Publication number
- ES2106772T3 ES2106772T3 ES91901253T ES91901253T ES2106772T3 ES 2106772 T3 ES2106772 T3 ES 2106772T3 ES 91901253 T ES91901253 T ES 91901253T ES 91901253 T ES91901253 T ES 91901253T ES 2106772 T3 ES2106772 T3 ES 2106772T3
- Authority
- ES
- Spain
- Prior art keywords
- variants
- pai
- pct
- sec
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Abstract
SE PRESENTAN VARIANTES DE UN ACTIVADOR INHIBIDOR DE PLASMA PAI-2 EN QUE LA ZONA DE RESIDUOS AMINOACIDOS (66-98) ES ALTERADA PARA ELIMINAR EL EMPLAZAMIENTO DE PROTEASA SENSITIVA. LAS VARIANTES DE LA INVENCION, MANTIENEN LA ACTIVIDAD BIOLOGICA DE PAI-2, Y AMINOACIDOS, POR ENCIMA DE 65 Y DE 99 PAI-2 EN PREPARADO. VARIANTES DE PAI-2 DE LA INVENCION, EN PREPARACION DE LABORATORIO, ASI COMO MOLECULAS DE DNA CODIFICANDO LAS VARIANTES DE LA INVENCION, CELULAS PATRON TRANSFORMADAS EXPRESANDO LAS VARIANTES DE LA INVENCION, COMPOSICION Y DIAGNOSTICO CONJUNTO, O COMPRENDIENDO LAS VARIANTES DE LA INVENCION, ANTICUERPOS CONTRA LAS VARIANTES DE LA INVENCION Y PROCESOS PARA LA PRODUCCION DE DICHAS VARIANTES, MOLECULAS DNA PATRONES DE TRANSFORMACION Y ANTICUERPOS DE LA INVENCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ792489 | 1989-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2106772T3 true ES2106772T3 (es) | 1997-11-16 |
Family
ID=3774424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91901253T Expired - Lifetime ES2106772T3 (es) | 1989-12-20 | 1990-12-20 | Variantes de pai-2. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5444153A (es) |
EP (1) | EP0458937B1 (es) |
JP (1) | JP2567536B2 (es) |
AT (1) | ATE156859T1 (es) |
AU (1) | AU625018B2 (es) |
DE (1) | DE69031271T2 (es) |
DK (1) | DK0458937T3 (es) |
ES (1) | ES2106772T3 (es) |
GR (1) | GR3025330T3 (es) |
WO (1) | WO1991009124A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346627B1 (en) | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
DE4214215A1 (de) * | 1992-04-30 | 1993-11-04 | Behringwerke Ag | Verwendung von inhibitoren von plasminogenaktivatoren zur behandlung von entzuendungen |
DE4214999C2 (de) * | 1992-05-06 | 1994-07-14 | Behringwerke Ag | Reinigung von Plasminogen-Aktivator-Inhibitor 2 durch Immunaffinitätschromatographie |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
CN1196701C (zh) * | 1997-03-19 | 2005-04-13 | 埃莫里大学 | 1,3-氧硒戊环核苷的合成及抗人类免疫缺陷病毒和抗乙肝病毒活性 |
US5994309A (en) * | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
KR20010042402A (ko) | 1998-04-01 | 2001-05-25 | 로잘란드 앤 칼도르 | 피부 상처의 치료를 위한 프로테아제 억제제의 용도 |
AUPP508798A0 (en) * | 1998-08-05 | 1998-08-27 | Biotech Australia Pty Limited | Method of treating psoriasis |
EP1066834A3 (de) * | 1999-07-08 | 2004-06-02 | Thomas Dr. Stief | Pharmazeutische Zusammensetzungen enthaltend ein phagozytenmodulierendes Agens |
AUPQ380699A0 (en) * | 1999-11-02 | 1999-11-25 | Biotech Australia Pty Limited | Protease inhibitors as modulators of periodontal wound healing |
AUPQ582400A0 (en) * | 2000-02-24 | 2000-03-16 | Biotech Australia Pty Limited | A method of treatment and agents for use therein |
US8062637B2 (en) * | 2000-05-08 | 2011-11-22 | Morphosys Ag | Methods of ameliorating inflammatory disease using an uPA antagonist |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
US6562572B1 (en) * | 2000-09-27 | 2003-05-13 | Mayo Foundation For Medical Education And Research | Methods for amplifying nucleic acid sequences |
US20110028397A1 (en) * | 2007-11-30 | 2011-02-03 | Toezser Jozsef | Use of Urokinase Type Plasminogen Activator Inhibitors for the Treatment of Corneal Disorders |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4923807A (en) * | 1984-05-18 | 1990-05-08 | New England Medical Center Hospitals Inc. | Arg-Serpin human plasminogen activator inhibitor designated PAI-2 |
EP0192671B1 (en) * | 1984-08-13 | 1993-12-29 | Biotechnology Australia Pty. Ltd. | Minactivin |
IL81879A (en) * | 1986-03-13 | 1994-07-31 | Biotech Australia Pty Ltd | Purification of minactivin for homogeneity, production of minactivin as recombinant techniques, and uses of homogeneous or recombinant minactivin |
AU608752B2 (en) * | 1986-03-13 | 1991-04-18 | Australian National University, The | Minactivin produced by recombinant dna technology |
DE3722673A1 (de) * | 1987-04-18 | 1989-01-19 | Behringwerke Ag | Fuer plasminogenaktivator-inhibitor, typ 2 (pai-2) codierende dna |
ES2104610T3 (es) * | 1989-09-05 | 1997-10-16 | Biotech Australia Pty Ltd | Proceso para la preparacion de pai-2. |
-
1990
- 1990-12-20 DK DK91901253.4T patent/DK0458937T3/da active
- 1990-12-20 WO PCT/AU1990/000603 patent/WO1991009124A1/en active IP Right Grant
- 1990-12-20 US US07/768,286 patent/US5444153A/en not_active Expired - Fee Related
- 1990-12-20 EP EP91901253A patent/EP0458937B1/en not_active Expired - Lifetime
- 1990-12-20 DE DE69031271T patent/DE69031271T2/de not_active Expired - Fee Related
- 1990-12-20 AT AT91901253T patent/ATE156859T1/de not_active IP Right Cessation
- 1990-12-20 ES ES91901253T patent/ES2106772T3/es not_active Expired - Lifetime
- 1990-12-20 JP JP3501647A patent/JP2567536B2/ja not_active Expired - Fee Related
- 1990-12-20 AU AU69671/91A patent/AU625018B2/en not_active Ceased
-
1997
- 1997-11-11 GR GR970402972T patent/GR3025330T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1991009124A1 (en) | 1991-06-27 |
AU625018B2 (en) | 1992-06-25 |
EP0458937B1 (en) | 1997-08-13 |
EP0458937A1 (en) | 1991-12-04 |
DE69031271T2 (de) | 1998-02-26 |
ATE156859T1 (de) | 1997-08-15 |
EP0458937A4 (en) | 1992-04-01 |
DE69031271D1 (de) | 1997-09-18 |
AU6967191A (en) | 1991-07-18 |
GR3025330T3 (en) | 1998-02-27 |
JPH04503761A (ja) | 1992-07-09 |
JP2567536B2 (ja) | 1996-12-25 |
US5444153A (en) | 1995-08-22 |
DK0458937T3 (da) | 1998-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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