ES2102021T3 - Nuevos antibioticos de aminosterol. - Google Patents

Nuevos antibioticos de aminosterol.

Info

Publication number
ES2102021T3
ES2102021T3 ES93905856T ES93905856T ES2102021T3 ES 2102021 T3 ES2102021 T3 ES 2102021T3 ES 93905856 T ES93905856 T ES 93905856T ES 93905856 T ES93905856 T ES 93905856T ES 2102021 T3 ES2102021 T3 ES 2102021T3
Authority
ES
Spain
Prior art keywords
aminosterol
antibiotics
new
colestano
aminopropil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905856T
Other languages
English (en)
Inventor
Michael Zasloff
Karen Moore
Suzanne Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
Original Assignee
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital of Philadelphia CHOP filed Critical Childrens Hospital of Philadelphia CHOP
Application granted granted Critical
Publication of ES2102021T3 publication Critical patent/ES2102021T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN ANTIBIOTICO DEL AMINOSTEROL, (3(BETA)(N-[3-AMINOPROPIL]-1,4BUTANODIAMINO)-7ALFA,24 (-DIHIDROXI-5ALFA-COLESTANO 24-SULFATO), EL CUAL PUEDE AISLARSE DEL ESTOMAGO DEL TIBURON PERRO MARINO, SQUALUS ACANTHIAS.
ES93905856T 1992-03-18 1993-02-10 Nuevos antibioticos de aminosterol. Expired - Lifetime ES2102021T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/853,634 US5192756A (en) 1992-03-18 1992-03-18 Aminosterol antibiotic

Publications (1)

Publication Number Publication Date
ES2102021T3 true ES2102021T3 (es) 1997-07-16

Family

ID=25316541

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905856T Expired - Lifetime ES2102021T3 (es) 1992-03-18 1993-02-10 Nuevos antibioticos de aminosterol.

Country Status (11)

Country Link
US (1) US5192756A (es)
EP (1) EP0637243B1 (es)
JP (1) JP3286321B2 (es)
AT (1) ATE152120T1 (es)
AU (1) AU675782B2 (es)
CA (1) CA2130803C (es)
DE (1) DE69310169T2 (es)
DK (1) DK0637243T3 (es)
ES (1) ES2102021T3 (es)
GR (1) GR3023749T3 (es)
WO (1) WO1993018773A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693769A (en) * 1991-12-13 1997-12-02 Transcell Technologies, Inc. Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US5780444A (en) * 1991-12-13 1998-07-14 Trustees Of Princeton University Compositions and methods for cell transformation
US5795870A (en) * 1991-12-13 1998-08-18 Trustees Of Princeton University Compositions and methods for cell transformation
WO1994019366A1 (en) * 1993-02-26 1994-09-01 Magainin Pharmaceuticals Inc. Chemical synthesis of squalamine
WO1994020520A1 (en) * 1993-03-10 1994-09-15 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
ES2164110T3 (es) * 1994-03-10 2002-02-16 Magainin Pharma Usos farmaceuticos de derivados de esteroides.
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
ES2216049T3 (es) * 1995-06-07 2004-10-16 Genaera Corporation Compuestos de aminosterol utiles como inhibidores del intercambiador de sodio/protones (nhe), metodos y composiciones farmaceuticas que emplean dichos inhibidores y procesos para evaluar la eficacia inhibidora de nhe de dichos compuestos.
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
AU4772696A (en) * 1996-01-26 1997-08-20 Alcon Laboratories, Inc. Use of squalamine and its analogues in ophthalmic compositions
ES2201296T3 (es) * 1996-04-26 2004-03-16 Genaera Corporation Escualmina en combinacion con otros farmacos anticancerigenos para el tratamiento de tumores.
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US7410959B1 (en) 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
CA2339174C (en) * 1998-08-12 2009-01-06 Magainin Pharmaceuticals, Inc. Aminosterol compounds and uses thereof
AU5342701A (en) * 2000-04-12 2001-10-30 Genaera Corp A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
US7309501B2 (en) * 2001-06-21 2007-12-18 Mote Marine Laboratory Conditioned media to inhibit growth of tumor cells
US6908627B2 (en) * 2001-06-21 2005-06-21 Mote Marine Laboratory Conditioned media for inhibiting growth of tumor cells
ES2727284T3 (es) 2005-04-25 2019-10-15 Enterin Inc Formas de sales polimórficas y amorfas de dilactato de escualamina
JP2010538072A (ja) * 2007-09-06 2010-12-09 ジェナエラ コーポレイション 糖尿病を治療する方法
WO2011056650A2 (en) 2009-10-27 2011-05-12 Michael Zasloff Methods and compositions for treating and preventing viral infections
US8623416B2 (en) * 2009-11-25 2014-01-07 Michael Zasloff Formulations comprising aminosterols
FR2981351A1 (fr) 2011-10-17 2013-04-19 Univ Nice Sophia Antipolis Derives aminosteroidiens anti-diabetiques
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
US9738684B2 (en) 2015-06-29 2017-08-22 Council Of Scientific & Industrial Research N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents
WO2019050903A1 (en) 2017-09-08 2019-03-14 Enterin Laboratories, Inc. METHODS OF TREATING SLEEP DISORDERS, SLEEP DISTURBANCES AND ASSOCIATED SYMPTOMS USING AMINOSTEROL COMPOSITIONS
US11066438B2 (en) 2017-10-30 2021-07-20 Enterin, Inc. Squalamine solid forms and methods of making the same
US11464789B2 (en) 2018-08-03 2022-10-11 Enterin, Inc. Aminosterol compositions and methods of using the same for treating schizophrenia
US20210260078A1 (en) * 2018-08-03 2021-08-26 Philadelphia Low dosage intranasal aminosterol dosage forms and methods of using the same
WO2021025988A1 (en) 2019-08-02 2021-02-11 Enterin, Inc. Dosing protocols and regimens for aminosterol treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3308116A (en) * 1963-07-05 1967-03-07 Ormonoterapia Richter Spa 2-carboxy amide-3-amino and 2, 3-isoxazole steroids
US3629298A (en) * 1969-02-24 1971-12-21 Upjohn Co Steroidal 3-keto-delta 1 4-diene-3-enamines
US3931403A (en) * 1973-05-25 1976-01-06 Intellectual Property Development Corporation Antimicrobial compositions

Also Published As

Publication number Publication date
AU3661993A (en) 1993-10-21
GR3023749T3 (en) 1997-09-30
JPH07504910A (ja) 1995-06-01
AU675782B2 (en) 1997-02-20
WO1993018773A1 (en) 1993-09-30
EP0637243B1 (en) 1997-04-23
US5192756A (en) 1993-03-09
ATE152120T1 (de) 1997-05-15
DE69310169T2 (de) 1997-09-18
EP0637243A1 (en) 1995-02-08
JP3286321B2 (ja) 2002-05-27
DE69310169D1 (de) 1997-05-28
CA2130803A1 (en) 1993-09-30
CA2130803C (en) 2007-04-17
EP0637243A4 (en) 1995-12-13
DK0637243T3 (da) 1997-05-20

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