ES2096740T3 - Procedimiento para la preparacion de 1h-benzimidazoles. - Google Patents

Procedimiento para la preparacion de 1h-benzimidazoles.

Info

Publication number
ES2096740T3
ES2096740T3 ES92870051T ES92870051T ES2096740T3 ES 2096740 T3 ES2096740 T3 ES 2096740T3 ES 92870051 T ES92870051 T ES 92870051T ES 92870051 T ES92870051 T ES 92870051T ES 2096740 T3 ES2096740 T3 ES 2096740T3
Authority
ES
Spain
Prior art keywords
benzimidazoles
benzimidazol
carboxyphenyl
preparation
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92870051T
Other languages
English (en)
Inventor
Gysel August Van
Andre Maquestiau
Eynde Jean-Jacques Vanden
Annie Mayence
Jean-Claude Vanovervelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proviron Fine Chemicals N V
Original Assignee
Proviron Fine Chemicals N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proviron Fine Chemicals N V filed Critical Proviron Fine Chemicals N V
Application granted granted Critical
Publication of ES2096740T3 publication Critical patent/ES2096740T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCESO DE PREPARACION DE 1H-BENCIMIDAZOLES SUSTITUIDOS EN POSICION 2, PREFERENTEMENTE DE LOS QUE RESPONDEN A LA FORMULA GENERAL (I): EN LA QUE R1 REPRESENTA UN ALQUILO LINEAL O RAMIFICADO QUE CONTIENE DE 1 A 13 ATOMOS DE CARBONO, UN FENILO, HALOGENOFENILO, 4-NITROFENILO, 4-CIANOFENILO, 4-CARBOXIFENILO, BENCILO, TIENILO, FURANILO, PIRIDINILO, 1,3 REPRESENTA UN ATOMO DE HIDROGENO O DE CLORO, NITRO O CARBOXILO, 2-(-CLOROFENIL)-1H-BENCIMIDAZOL-5-ILO, O 2-(4CARBOXILFENILO)1H-BENCIMIDAZOL-5-ILO, Y N ES IGUAL A 1 O 2. SEGUN LA INVENCION, SE HACEN REACCIONAR JUNTOS UN ALDEHIDO CON UN HALOGENURO DE TIONILO Y UN COMPUESTO HETEROCICLICO AROMATICO NITROGENADO, SE HACE REACCIONAR A CONTINUACION EL PRODUCTO FORMADO CON UNA 1,2-BENCENODIAMINA EVENTUALMENTE SUSTITUIDA Y SE SEPARA EL 1H-BENCIMIDAZOL ASI OBTENIDO DE LA MEZCLA DE REACCION. POR ESTE PROCESO, SE OBTIENEN LOS 1H-BENCIMIDAZOLES EN UNA SOLA ETAPA, EN CONDICIONES MODERADAS, CON RENDIMIENTOS MUY ELEVADOS.
ES92870051T 1991-04-18 1992-03-30 Procedimiento para la preparacion de 1h-benzimidazoles. Expired - Lifetime ES2096740T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108279A GB9108279D0 (en) 1991-04-18 1991-04-18 A method of preparing 1h-benzimidazoles

Publications (1)

Publication Number Publication Date
ES2096740T3 true ES2096740T3 (es) 1997-03-16

Family

ID=10693485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92870051T Expired - Lifetime ES2096740T3 (es) 1991-04-18 1992-03-30 Procedimiento para la preparacion de 1h-benzimidazoles.

Country Status (7)

Country Link
EP (1) EP0511187B1 (es)
AT (1) ATE145398T1 (es)
DE (1) DE69215266T2 (es)
DK (1) DK0511187T3 (es)
ES (1) ES2096740T3 (es)
GB (1) GB9108279D0 (es)
GR (1) GR3022603T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
EP1435947B1 (en) * 2001-10-19 2007-08-15 Ortho-McNeil Pharmaceutical, Inc. 2-phenyl benzimidazoles and imidazo-¬4,5|-pyridines as cds1/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
EP2251010A1 (en) 2009-05-08 2010-11-17 Sygnis Bioscience GmbH & Co. KG Use of thiabendazole and derivatives thereof for the therapy of neurological conditions
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
CN101735152A (zh) * 2009-12-18 2010-06-16 长沙理工大学 2,2'-(1,4-亚苯基)二(苯并咪唑-5-羧酸)及其制备方法
DK2575968T3 (en) 2010-06-01 2016-05-30 Summit Therapeutics Plc COMPOUNDS FOR THE TREATMENT OF Clostridium difficile-associated disease
KR20150039551A (ko) * 2013-10-02 2015-04-10 제이에스알 가부시끼가이샤 경화성 조성물, 경화막 및 그의 형성 방법, 그리고 화합물
CN110272390A (zh) * 2019-07-15 2019-09-24 北京大学 多聚磷酸盐激酶靶向抑制剂p8

Also Published As

Publication number Publication date
EP0511187A1 (fr) 1992-10-28
DE69215266D1 (de) 1997-01-02
GR3022603T3 (en) 1997-05-31
GB9108279D0 (en) 1991-06-05
ATE145398T1 (de) 1996-12-15
DK0511187T3 (da) 1997-04-07
EP0511187B1 (fr) 1996-11-20
DE69215266T2 (de) 1997-05-28

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