ES2096617T3 - Uso de estafiloquinasa para la preparacion de una composicion farmaceutica para tratar trombosis arterial. - Google Patents

Uso de estafiloquinasa para la preparacion de una composicion farmaceutica para tratar trombosis arterial.

Info

Publication number
ES2096617T3
ES2096617T3 ES91201670T ES91201670T ES2096617T3 ES 2096617 T3 ES2096617 T3 ES 2096617T3 ES 91201670 T ES91201670 T ES 91201670T ES 91201670 T ES91201670 T ES 91201670T ES 2096617 T3 ES2096617 T3 ES 2096617T3
Authority
ES
Spain
Prior art keywords
staphylokinase
preparation
pharmaceutical composition
arterial thrombosis
treat arterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91201670T
Other languages
English (en)
Inventor
Desire Jose Collen
Jean-Marie Stassen
Henri Roger Lijnen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Application granted granted Critical
Publication of ES2096617T3 publication Critical patent/ES2096617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL PRESENTE INVENTO DESCRIBE EL USO DE ESTAFILOQUINASA PARA LA PREPARACION DE UN COMPUESTO FARMACEUTICO PARA TRATAR LA TROMBOSIS ARTERIAL, COMO POR EJEMPLO INFARTO DE MIOCARDIO. ESTA DEMOSTRADO QUE LA ESTAFILOQUINASA PUEDE SER PARTICULARMENTE UTIL COMO AGENTE TROMBOLITICO PARA LA LISIS DE COAGULOS RICOS EN PLAQUETAS. ADEMAS ESTA DEMOSTRADO QUE LA ESTAFILOQUINASA, A DIFERENCIA DE LA ESTREPTOQUINASA NO INDUCE INDUCCION ANTICUERPO TRAS SU ADMINISTRACION REPETIDA.
ES91201670T 1991-06-28 1991-06-28 Uso de estafiloquinasa para la preparacion de una composicion farmaceutica para tratar trombosis arterial. Expired - Lifetime ES2096617T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91201670A EP0525252B1 (en) 1991-06-28 1991-06-28 Use of staphylokinase for the preparation of a pharmaceutical composition for treating arterial thrombosis

Publications (1)

Publication Number Publication Date
ES2096617T3 true ES2096617T3 (es) 1997-03-16

Family

ID=8207747

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91201670T Expired - Lifetime ES2096617T3 (es) 1991-06-28 1991-06-28 Uso de estafiloquinasa para la preparacion de una composicion farmaceutica para tratar trombosis arterial.

Country Status (7)

Country Link
US (1) US5336495A (es)
EP (1) EP0525252B1 (es)
AT (1) ATE147989T1 (es)
DE (1) DE69124370T2 (es)
DK (1) DK0525252T3 (es)
ES (1) ES2096617T3 (es)
GR (1) GR3023211T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen
US6383483B1 (en) 1995-01-06 2002-05-07 Désiré José Collen Staphylokinase derivatives with cysteine substitutions
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
CN1322126C (zh) * 1998-02-04 2007-06-20 思罗姆-X股份有限公司 免疫原性降低和/或清除率降低的葡激酶衍生物的鉴定、生产和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68912383T3 (de) * 1988-04-14 1999-06-02 Yakult Honsha Kk Plasminogenaktivator und thrombolytischer Wirkstoff.

Also Published As

Publication number Publication date
ATE147989T1 (de) 1997-02-15
EP0525252B1 (en) 1997-01-22
DE69124370T2 (de) 1997-05-15
DE69124370D1 (de) 1997-03-06
DK0525252T3 (da) 1997-07-28
EP0525252A1 (en) 1993-02-03
US5336495A (en) 1994-08-09
GR3023211T3 (en) 1997-07-30

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