ES2095751T3 - Regulacion selectiva de hemoglobinas mediante sacaridos de anillo abierto oxidados. - Google Patents
Regulacion selectiva de hemoglobinas mediante sacaridos de anillo abierto oxidados.Info
- Publication number
- ES2095751T3 ES2095751T3 ES94908913T ES94908913T ES2095751T3 ES 2095751 T3 ES2095751 T3 ES 2095751T3 ES 94908913 T ES94908913 T ES 94908913T ES 94908913 T ES94908913 T ES 94908913T ES 2095751 T3 ES2095751 T3 ES 2095751T3
- Authority
- ES
- Spain
- Prior art keywords
- saccharide
- hemoglobin
- tri
- reaction
- hemoglobins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001554 Hemoglobins Human genes 0.000 title abstract 5
- 108010054147 Hemoglobins Proteins 0.000 title abstract 5
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 title 1
- 150000001720 carbohydrates Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000004043 trisaccharides Chemical class 0.000 abstract 3
- 229920001744 Polyaldehyde Polymers 0.000 abstract 2
- 238000007142 ring opening reaction Methods 0.000 abstract 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
- 239000002262 Schiff base Substances 0.000 abstract 1
- 150000004753 Schiff bases Chemical class 0.000 abstract 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003633 blood substitute Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- -1 raffinose Chemical class 0.000 abstract 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
HEMOGLOBINA PARA FORMAR LAS BASES DE UN SUSTITUTO SANGUINEO SE MODIFICA POR RETICULACION REACCIONANDOLA CON UN POLIALDEHIDO PRODUCIDO POR OXIDACION DE ABERTURA DE ANILLO DE UN DI/TRI-SACARIDO TAL COMO RAFINOSA, DONDE LAS SOLUCIONES DE O-SACARIDO SE MANTIENEN Y LA REACCION ES CONDUCIDA A UN PH DE APROXIMADAMENTE 5.0 A 7.0, Y A UNA ESTOIQUIOMETRIA DE APROXIMADAMENTE 1: A 4:1 BASADA EN LA RELACION MOLAR DE DI/TRI-SACARIDO A TETRAMEROS DE HEMOGLOBINA, SEGUIDO POR LA REDUCCION APROPIADA DE LOS ENLACES DE BASE SCHIFF ASI FORMADOS PARA ESTABILIZARLOS. EL CONTROL CUIDADOSO DEL PH DE LA ABERTURA AL DI/TRI-SACARIDO ASEGURA LA PRODUCCION CONSISTENTE DEL POLIALDEHIDO SIN PRODUCTOS SECUNDARIOS NO DESEADOS Y REACCION DE ESTE PRODUCTO CON LA HEMOGLOBINA A LA ESTOIQUIOMETRIA ESPECIFICADA CONDUCE A GRANDES PRODUCCIONES DE HEMOGLOBINA TERAMERICA ESTABILIZADA Y SUS OLIGOMEROS DE COMPOSICION PREDETERMINADA Y PROPIEDADES BENEFICIOSAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3183093A | 1993-03-16 | 1993-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2095751T3 true ES2095751T3 (es) | 1997-02-16 |
Family
ID=21861634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94908913T Expired - Lifetime ES2095751T3 (es) | 1993-03-16 | 1994-03-11 | Regulacion selectiva de hemoglobinas mediante sacaridos de anillo abierto oxidados. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5532352A (es) |
| EP (1) | EP0646130B1 (es) |
| JP (1) | JP2594241B2 (es) |
| KR (1) | KR100306000B1 (es) |
| CN (1) | CN1046292C (es) |
| AT (1) | ATE146189T1 (es) |
| AU (1) | AU668294B2 (es) |
| CA (1) | CA2131455C (es) |
| DE (1) | DE69401109T2 (es) |
| DK (1) | DK0646130T3 (es) |
| ES (1) | ES2095751T3 (es) |
| NZ (1) | NZ262349A (es) |
| WO (1) | WO1994021682A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE503711C2 (sv) * | 1994-12-14 | 1996-08-12 | Medicarb Ab | Flerstegsförfarande för beläggning av en intraokulär lins |
| US5952470A (en) * | 1995-06-07 | 1999-09-14 | Biopure Corporation | Method for separating unmodified hemoglobin from cross-linked hemoglobin |
| US5891506A (en) * | 1996-08-09 | 1999-04-06 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices |
| EP0939644B1 (en) * | 1996-08-27 | 2004-01-14 | Hemosol Inc. | Enhanced stimulation of erythropoiesis |
| US5917020A (en) * | 1997-01-15 | 1999-06-29 | Kluger; Ronald H. | Bis-tetrameric hemoglobin and reagents for its production |
| US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| JP4583510B2 (ja) * | 1997-02-28 | 2010-11-17 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 無細胞系による酸素輸送の最適化のための方法と組成物 |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| CA2266174A1 (en) * | 1999-03-18 | 2000-09-18 | Hemosol Inc. | Hemoglobin-antioxidant conjugates |
| DE19933275A1 (de) * | 1999-07-14 | 2001-01-18 | Fresenius Ag | Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens |
| US6894150B1 (en) | 1999-10-01 | 2005-05-17 | Ross Walden Tye | Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin |
| US6500809B1 (en) | 1999-11-12 | 2002-12-31 | Neuron Therapeutics, Inc. | Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith |
| DE10031742A1 (de) * | 2000-06-29 | 2002-01-17 | Sanguibio Tech Ag | Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine |
| DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
| US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
| DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
| RU2329274C2 (ru) | 2002-09-11 | 2008-07-20 | Фрезениус Каби Дойчланд Гмбх | Способ получения производных гидроксиалкилкрахмала |
| ES2314238T3 (es) | 2002-10-08 | 2009-03-16 | Fresenius Kabi Deutschland Gmbh | Conjugados de oligosacaridos farmaceuticamente activos. |
| WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| US7135554B1 (en) * | 2004-01-27 | 2006-11-14 | Biopure Corporation | Method of forming a polymerized hemoglobin solution from stabilized hemoglobin |
| CA2558738C (en) | 2004-03-11 | 2013-02-05 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
| EP1865993A2 (en) * | 2005-04-05 | 2007-12-19 | Biopure Corporation | Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization |
| US7504377B2 (en) * | 2006-10-23 | 2009-03-17 | Ikor, Inc. | Nitric oxide-blocked cross-linked tetrameric hemoglobin |
| US7494974B2 (en) * | 2006-10-24 | 2009-02-24 | Ikor, Inc. | Carboxymethylated cross-linked tetrameric hemoglobin |
| EP2070950A1 (en) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkyl starch derivatives and process for their preparation |
| US20140260586A1 (en) * | 2013-03-14 | 2014-09-18 | Schlumberger Technology Corporation | Method to perform rapid formation fluid analysis |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| JPH0645681B2 (ja) * | 1986-02-05 | 1994-06-15 | 美浜 久春 | 修飾ヘム |
| DE3636590A1 (de) * | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| FR2640141B1 (fr) * | 1988-12-14 | 1993-04-16 | Merieux Inst | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
| US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| DE69108258T2 (de) * | 1990-11-29 | 1995-08-10 | Upjohn Co | Mit imidoester quer-vernetzte hämoglobinzusammensetzungen. |
| FR2680369B1 (fr) * | 1991-08-14 | 1993-11-05 | Pasteur Merieux Serums Vaccins | Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits. |
| US5399671A (en) * | 1992-11-18 | 1995-03-21 | Kluger; Ronald | Specifically crosslinked hemoglobin with free functionality |
-
1994
- 1994-03-11 AT AT94908913T patent/ATE146189T1/de not_active IP Right Cessation
- 1994-03-11 EP EP94908913A patent/EP0646130B1/en not_active Expired - Lifetime
- 1994-03-11 ES ES94908913T patent/ES2095751T3/es not_active Expired - Lifetime
- 1994-03-11 NZ NZ262349A patent/NZ262349A/en not_active IP Right Cessation
- 1994-03-11 AU AU61793/94A patent/AU668294B2/en not_active Ceased
- 1994-03-11 JP JP6520446A patent/JP2594241B2/ja not_active Expired - Fee Related
- 1994-03-11 DE DE69401109T patent/DE69401109T2/de not_active Expired - Fee Related
- 1994-03-11 CA CA002131455A patent/CA2131455C/en not_active Expired - Fee Related
- 1994-03-11 KR KR1019940703254A patent/KR100306000B1/ko not_active Expired - Fee Related
- 1994-03-11 WO PCT/CA1994/000140 patent/WO1994021682A1/en not_active Ceased
- 1994-03-11 DK DK94908913.0T patent/DK0646130T3/da active
- 1994-03-11 CN CN94190130A patent/CN1046292C/zh not_active Expired - Fee Related
- 1994-04-21 US US08/231,945 patent/US5532352A/en not_active Expired - Lifetime
-
1996
- 1996-06-28 US US08/672,868 patent/US5770727A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1046292C (zh) | 1999-11-10 |
| JPH07506123A (ja) | 1995-07-06 |
| CA2131455A1 (en) | 1994-09-29 |
| DE69401109T2 (de) | 1997-05-28 |
| NZ262349A (en) | 1996-05-28 |
| DK0646130T3 (da) | 1997-06-02 |
| KR100306000B1 (ko) | 2001-12-01 |
| US5770727A (en) | 1998-06-23 |
| AU6179394A (en) | 1994-10-11 |
| EP0646130A1 (en) | 1995-04-05 |
| CA2131455C (en) | 1998-08-18 |
| ATE146189T1 (de) | 1996-12-15 |
| DE69401109D1 (de) | 1997-01-23 |
| EP0646130B1 (en) | 1996-12-11 |
| AU668294B2 (en) | 1996-04-26 |
| JP2594241B2 (ja) | 1997-03-26 |
| WO1994021682A1 (en) | 1994-09-29 |
| CN1105800A (zh) | 1995-07-26 |
| US5532352A (en) | 1996-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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