ES2095749T3 - Compuestos de alquilamino etinil alanina amino diol imidazolil/bencimidazolil-terminados utiles para el tratamiento de la hipertension. - Google Patents
Compuestos de alquilamino etinil alanina amino diol imidazolil/bencimidazolil-terminados utiles para el tratamiento de la hipertension.Info
- Publication number
- ES2095749T3 ES2095749T3 ES94908098T ES94908098T ES2095749T3 ES 2095749 T3 ES2095749 T3 ES 2095749T3 ES 94908098 T ES94908098 T ES 94908098T ES 94908098 T ES94908098 T ES 94908098T ES 2095749 T3 ES2095749 T3 ES 2095749T3
- Authority
- ES
- Spain
- Prior art keywords
- hypertension
- treatment
- bencimidazolyl
- imidazolil
- ethinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LOS COMPUESTOS CARACTERIZADOS GENERALMENTE COMO DERIVADOS DEL AMINO DIOL DE ALQUILAMINO-ETINIL-ALANINA TERMINADOS EN IMIDAZOLILO/BENZIMIDAZOLILO SON UTILES COMO INHIBIDORES DE LA RENINA PARA EL TRATAMIENTO DE LA HIPERTENSION. COMPUESTOS DE PARTICULAR INTERES SON AQUELLOS DE LA FORMULA (I), EN LA QUE A SE SELECCIONA ENTRE CO Y SO2; X SE SELECCIONA ENTRE UN ATOMO DE OXIGENO Y METILENO; B SE SELECCIONA ENTRE GRUPOS DE IMIDAZOLILO Y BENCIIMIDAZOLILO; R1 SE SELECCIONA ENTRE HIBRIDO, METILO, ETILO, ISOPROPILO Y N-PROPILO; R2 Y R3 FENILMETILO; CADA R3 Y R5 ES HIBRIDO; R4 SE SELECCIONA ENTRE ( ) EN DONDE V SE SELECCIONA ENTRE HIBRIDO Y METILO; R6 ES CICLOHEXILMETILO; R7 SE SELECCIONA ENTRE ISOBUTILO, CICLOPROPILO Y CICLOPROPILMETILO; Q ES UN NUMERO SELECCIONADO ENTRE 0 Y 3; Y N ES UN NUMERO SELECCIONADO ENTRE 0 Y 3; TAMBIEN SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/930,076 US5373017A (en) | 1992-08-14 | 1992-08-14 | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095749T3 true ES2095749T3 (es) | 1997-02-16 |
Family
ID=25458896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94908098T Expired - Lifetime ES2095749T3 (es) | 1992-08-14 | 1993-08-13 | Compuestos de alquilamino etinil alanina amino diol imidazolil/bencimidazolil-terminados utiles para el tratamiento de la hipertension. |
Country Status (11)
Country | Link |
---|---|
US (3) | US5373017A (es) |
EP (1) | EP0655059B1 (es) |
JP (1) | JPH08500118A (es) |
AT (1) | ATE146460T1 (es) |
AU (1) | AU669005B2 (es) |
CA (1) | CA2136838A1 (es) |
DE (1) | DE69306794T2 (es) |
DK (1) | DK0655059T3 (es) |
ES (1) | ES2095749T3 (es) |
GR (1) | GR3022103T3 (es) |
WO (1) | WO1994004508A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5373017A (en) * | 1992-08-14 | 1994-12-13 | G. D. Searle & Co. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US20020115867A1 (en) * | 1992-08-14 | 2002-08-22 | Hanson Gunnar J. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5508466A (en) * | 1994-04-13 | 1996-04-16 | G.D. Searle & Co. | Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent |
US7355068B2 (en) * | 2006-01-04 | 2008-04-08 | Eastman Chemical Company | Oxidation system with internal secondary reactor |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769271A (en) * | 1971-04-15 | 1973-10-30 | Lilly Co Eli | N-protected amino acids and peptides |
JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
SU1676454A3 (ru) * | 1984-11-30 | 1991-09-07 | Санкио Компани Лимитед (Фирма) | Способ получени пептидов или их фармацевтически приемлемых солей |
DK34086A (da) * | 1985-01-23 | 1986-07-24 | Abbott Lab | Peptidylaminodioler |
JPS61236770A (ja) * | 1985-04-15 | 1986-10-22 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
JPS6256458A (ja) * | 1985-09-04 | 1987-03-12 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
IL81234A (en) * | 1986-01-16 | 1992-09-06 | Abbott Lab | Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them |
JPS63503380A (ja) * | 1986-01-16 | 1988-12-08 | アボット・ラボラトリーズ | ペプチド類似体 |
US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
US4921855A (en) * | 1987-06-22 | 1990-05-01 | Fujisawa Pharmaceutical Co., Ltd. | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same |
US5036051A (en) * | 1987-10-06 | 1991-07-30 | Abbott Laboratories | Glaucoma treatment |
US5036053A (en) * | 1988-05-27 | 1991-07-30 | Warner-Lambert Company | Diol-containing renin inhibitors |
US4902706A (en) * | 1988-07-01 | 1990-02-20 | G. D. Searle & Co. | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents |
IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
US5175181A (en) * | 1989-12-04 | 1992-12-29 | G. D. Searle & Co. | Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy |
IE68045B1 (en) * | 1990-05-11 | 1996-05-15 | Abbott Lab | Renin inhibitors |
EP0539976A1 (en) * | 1991-10-29 | 1993-05-05 | G.D. Searle & Co. | Ethynyl-alanine-amino-diol compounds for treatment of hypertension |
US5373017A (en) * | 1992-08-14 | 1994-12-13 | G. D. Searle & Co. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
-
1992
- 1992-08-14 US US07/930,076 patent/US5373017A/en not_active Expired - Fee Related
-
1993
- 1993-08-13 WO PCT/US1993/007511 patent/WO1994004508A1/en active IP Right Grant
- 1993-08-13 ES ES94908098T patent/ES2095749T3/es not_active Expired - Lifetime
- 1993-08-13 AT AT94908098T patent/ATE146460T1/de not_active IP Right Cessation
- 1993-08-13 JP JP6506361A patent/JPH08500118A/ja not_active Ceased
- 1993-08-13 CA CA002136838A patent/CA2136838A1/en not_active Abandoned
- 1993-08-13 EP EP94908098A patent/EP0655059B1/en not_active Expired - Lifetime
- 1993-08-13 AU AU50037/93A patent/AU669005B2/en not_active Ceased
- 1993-08-13 DE DE69306794T patent/DE69306794T2/de not_active Expired - Fee Related
- 1993-08-13 DK DK94908098.0T patent/DK0655059T3/da active
-
1996
- 1996-12-19 GR GR960403151T patent/GR3022103T3/el unknown
-
2002
- 2002-11-08 US US10/290,944 patent/US20030130329A1/en not_active Abandoned
-
2003
- 2003-08-12 US US10/639,394 patent/US20040087801A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5003793A (en) | 1994-03-15 |
JPH08500118A (ja) | 1996-01-09 |
US5373017A (en) | 1994-12-13 |
ATE146460T1 (de) | 1997-01-15 |
DE69306794T2 (de) | 1997-05-07 |
US20030130329A1 (en) | 2003-07-10 |
EP0655059B1 (en) | 1996-12-18 |
GR3022103T3 (en) | 1997-03-31 |
DK0655059T3 (da) | 1997-01-06 |
DE69306794D1 (de) | 1997-01-30 |
US20040087801A1 (en) | 2004-05-06 |
AU669005B2 (en) | 1996-05-23 |
CA2136838A1 (en) | 1994-03-03 |
WO1994004508A1 (en) | 1994-03-03 |
EP0655059A1 (en) | 1995-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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